The correlation of recovery of Candida albicans from the skin, rectum and faeces of four clinically distinct groups of infants with napkin (diaper) dermatitis has been studied. We found that: (I) C. albicans is largely and constantly present both on the skin and in faeces of subjects with clinically overt Candidiasis of the napkin area; (2) C. albicans is lacking from both the skin and faeces of subjects with chafing or atopic dermatitis; (3) C. albicans can be found in faeces of subjects with unclassifiable napkin dermatitis in a direct relationship with its clinical severity; (4) failure to recover C. albicans from the skin can be due to the inhibitory effect of the inflammatory host reaction and therefore can be misleading.

Candida albicans↗

PubMed1981

Acute diffuse scleroderma.

A case of acute diffuse scleroderma without contemporaneous visceral involvement is described. Antibodies to endothelial cells have been found in the skin.

Acute Disease↗

PubMed1981

Metronidazole and Demodex folliculorum.

In vitro survival of Demodex folliculorum was tested in the presence of various concentrations of metronidazole (Flagyl). Demodex was found to survive in concentrations of as much as 1 mg/ml. Thus, it seems unlikely that the effect of metronidazole on rosacea is attributable to its direct activity on the mite.

Hair↗

PubMed1980

Flushing in rosacea: an experimental approach.

A simple method is described which causes rosacea patients to flush. This flush is experienced similarly to the flush which occurs spontaneously and its intensity can be measured and monitored quantitatively. Therefore, it can be used as a suitable experimental tool to measure and compare the inhibitory effects of some drugs, as well as the fluctuations of the blood level of certain chemical vasoactive mediators.

Adult↗

PubMed1980

Immunopathological studies on rosacea.

Seven patients with papulo-pustular rosacea were investigated with immunofluorescence (IF) techniques. Indirect IF has been performed also with antibodies eluted from circulating lymphoid cells. Besides confirming the data in the literature on the positivity of the basal zone, anticollagen antibodies were found, and eluted antinuclear antibodies were detected against nuclei of cells in the epidermis and dermis, namely, scattered dermal, endothelial and eccrine duct cells.

Adult↗

PubMed1980

Neutrophil dysfunction and repeated infections: influence of levamisole and ascorbic acid.

Neutrophil function was studied in several patients with recurrent infections, mainly of the skin. Twelve patients showed impairment of neutrophil functions, either chemotaxis or bacterial killing and phagocytosis. Levamisole was given in four cases: improvement of neutrophil function and long-lasting clinical remission occurred in three of them, whilst in the fourth the drug was not tolerated. Ascorbic acid was administered to three other patients, with satisfactory improvement of neutrophil function and long-lasting clinical remission.

Adolescent↗

PubMed1980

Repeated staphylococcal pyoderma in two siblings with defective neutrophil bacterial killing.

2 children with undue susceptibility to skin infections and isolated defective neutrophil bacterial killing are described. Since the NBT-reducing capabilities of granulocytes were normal, a mild form of chronic granulomatous disease was excluded. Ascorbic acid was effective in delaying and eventually suppressing infectious episodes.

Ascorbic Acid↗

PubMed1980

Hair casts.

Peripilar hair casts are a pathological occurrence which is probably greater than the few reports seem to suggest. In 2 patients the authors have found fine, whitish nodular accretions of epithelial cells and keratinous debris surrounding the hair shafts of the scalp over a length of 3--7 mm located at various distances from the base of the hair along which they can freely move. Long-term or repetitive tractions incidental to modern hair styling or a moderate trichotillomania due to anxiety for hair loss are probably the causative factors.

Adult↗

PubMed1980

Preliminary results of a clinical trial relative to the use of rifamycin SV in the treatment of herpes zoster.

In a controlled clinical trial undertaken in ten Italian centres, rifamycin SV was compared to associations of various drugs such as erythromycin, aureomycin, multivitamin preparations, etc, in the treatment of herpes zoster. Up to now 144 patients, suffering from herpes zoster at different localizations, were divided into three groups and randomly given either rifamycin SV by intramuscular injection and topically, or rifamycin SV by injection only, or the routine treatment used at the particular centre in question. To evaluate the effectiveness of the treatments, the presence of subjective and objective symptoms was determined before treatment started and daily thereafter. The duration, in days, of the most important symptoms, such as erythema, vesicles, scabs and pain, was considered for this partial evaluation. All the above-mentioned symptoms constantly showed a shorter duration in the two groups treated with rifamycin SV compared to the group treated with other therapies, with differences as significant on statistical calculation as they were important on the level of a clinical evaluation of the disease's course.

Administration, Topical↗

PubMed1980

Defective neutrophil function in an adult patient with repeated infections.

Explore the source record for details and available documents.

Ascorbic Acid↗

PubMed1980

Exophthalmos in relapsing polychondritis.

Explore the source record for details and available documents.

Aged↗