Iatrogenic false-positive Crithidia luciliae immunofluorescence test.
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Biomedical subjects
Publications and source records attributed to A Rebora.
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A patient is described in whom a papulo-nodular eruption occurred in association with systemic lupus erythematosus. Histopathology disclosed a diffuse deposition of mucin, mainly hyaluronic acid, in the dermis. This, and the 10 similar cases which have been reported in the literature, belong to a distinct clinico-pathological entity for which we propose the eponym of papular and nodular mucinosis of Gold, after the first observer to report it.
A patient is described with a tumour of the upper lip which was proved histologically to be a microcystic adnexal carcinoma, probably derived from the outer hair root sheath. This appears to be the eighth in the literature.
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A technique is described for quantitatively measuring the rate of cerumen production. Two different washing solutions were tried. A mixture of alcohol/ether (3:1 v/v) appeared to be the best extracting solution yielding 2.05 +/- 0.22 versus 0.73 +/- 0.14 mg/week per ear obtained with Triton X-100 solution. In addition, reproducibility was definitely better. Triton X-100 may be useful whenever microbiologic evaluations are requested. Total lipids accounted for 73.3% of cerumen extracted with the former solution, triglycerides being 19.5%, and cholesterol 7.2%. Our extracting technique appears to be a good estimate of the cerumen global output and may supply important information about cerumen in several biologic conditions.
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A case of acquired progressive kinking of the hair is described. Scanning electron microscopy disclosed many hair malformations, including pili canaliculi and twisted and beaded hairs.
A patient with Ofuji's eosinophilic pustulosis and peculiar immunofluorescence findings is described. High titers of circulating IgG and IgM have been found directed to the cytoplasm of the basal cells of epidermis and the outer sheath of hair follicles. Such antibodies appear to be related to the course of the disease.
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The deposition of speckled-patterned immunoglobulins in epidermal nuclei has been investigated in seventeen patients with various diseases other than mixed connective tissue disease. The phenomenon was seen not only with low titres of circulating antinuclear antibodies of IgG and IgM classes, but even in their absence. The clinical significance of this finding remains obscure, but the common explanation, that it is a simple artifact, seems quite untenable.
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