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Biomedical subjects

A Reale

Publications and source records attributed to A Reale.

At least 163 records · Page 9Linked to original sources
PubMed1980

[Hypertrophic obstructive cardiomyopathy associated with significant coronary artery stenosis. Apropos of 2 cases. Diagnostic and therapeutic considerations and review of the literature].

Hypertrophic obstructive cardiomyopathy (HOCM) is rarely associated with significant coronary artery stenosis. Differential diagnosis may be difficult because of similar symptoms; therefore we suggest coronary arteriography in all patients above 30 years of age having HOCM and angina associated. Obviously, in case the clinical diagnosis is coronary artery occlusive disease, left ventriculography is mandatory to rule out HOCM. Four medical treatment beta-blocking agents are the drugs of choice associated, if needed, with coronary dilators, avoiding nitrates. In case surgical treatment is selected, complete correction of all lesions is indicated.

Adrenergic beta-Antagonists↗
PubMed1979

Acute influence of different beta-blocking agents upon left heart hemodynamics at rest and during exercise in patients with coronary artery disease.

The study investigated the acute hemodynamic changes induced in patients with angiographically confirmed coronary artery disease by 3 beta-blockers: metoprolol, cardioselective without intrinsic sympathomimetic activity (ISA), group I, 11 patients; bunitrolol, noncardioselective with ISA, group II, 11 patients; oxprenolol, noncardioselective with ISA, group III, 11 patients. Hemodynamic variables were obtained at rest and during exercise, before and 45 min after 10 mg i.v. of the drug. Changes in LVEDP and cardiac indexes were such as LV function was improved in 1 patient of group I, 7 patients of group II and 5 patients of group III; impaired in 4 patients of group I and in 1 patient of group III; unchanged in the others. Contractility indexes were less influenced by bunitrolol and oxprenolol. During exercise there was a significant difference between groups for LVEDP which was lower in group II (P less than 0.01). The data seem to indicate that the choice of the beta-blocker may be of importance when it is desirable that an already compromised cardiac function be not further impaired by pharmacological intervention.

Adrenergic beta-Antagonists↗