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Biomedical subjects

A Reale

Publications and source records attributed to A Reale.

At least 181 records · Page 10Linked to original sources
PubMed1976

Evidence for improved cardiac performance after beta-blockade in patients with coronary artery disease.

The study was undertaken to investigate the acute haemodynamic effects of bunitrolol (0-2-hydroxy-3-(tert.butylamino)-propoxy)-bity. Right and left heart catheterization was performed in eleven patients with documented coronary artery disease. After bunitrolol (10 mg i.v.), there was a statistically significant decrease in left ventricular and aortic systolic pressures left ventricular end-diastolic pressure, aortic diastolic and mean pressures, pressure-rate product and compliance index (delta P/delta V). Left ventricular dp/dt, left ventricular dp/dt over isovolumic pressure, systemic resistance and heart rate tended to decrease, stroke volume and left ventricular stroke work index tended to increase, without statistical significance. Cardiac index showed individual variations, the mean values for the group being unchanged. Correlation of left ventricular end-diastolic pressure and left ventricular stroke work index showed a shift toward improved ventricular function curve in most cases, deterioration in no instance. Supine exercise was performed in ten patients. Angina occurred in nine patients; in five only before and in four before and after beta-blockade. Post-drug exercise heart rate, pressure-rate product and left ventricular end-diastolic pressure were significantly lower, the latter also in the four patients who still presented exercise angina. It is concluded that certain beta-blockers can improve cardiac performance at rest and during exercise in patients with coronary artery disease. This is explainable on the basis of a more favourable balance between oxygen supply and demand, together with a less marked negative inotropic effect due to the partial agonist activity of the agent used in the study.

Adult↗
PubMed1975

[Exercise test and atrial pacing in angina pectoris: behaviour of adrenosympathetic system (author's transl)].

Arterial plasma noradrenaline and adrenaline concentrations before, during and after an attack of pain, induced first by constant supine exercise and then by multistep atrial pacing, were determined in four patients with coronary occlusion disease and stable angina pectoris. An identical protocol was applied to a patient with atypical precordial pain (anxiety state) and normal coronary arteriograms. When compared, the results led to the following conclusions: 1) during supine exercise arterial plasma catecholamine concentrations, particularly noradrenaline, progressively increase, reaching highest values in temporal coincidence with the onset or the peak of pain, 2) during multistep atrial pacing-induced angina no significant changes of arterial plasma catecholamine concentrations are seen. These data, obtained from the same patients, further emphasize that the application of atrial pacing to the study of pathophysiology of angina pectoris and for evaluating antianginal drugs, especially if interfering with adrenosympathetic system activity, must be considered with caution.

Adrenal Glands↗