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Biomedical subjects

A Rashid

Publications and source records attributed to A Rashid.

At least 163 records · Page 9Linked to original sources
PubMed1975

Thromboembolism associated with pigtail catheters.

Three incidents of asymptomatic arterial thromboembolism associated with polyurethane pigtail catheters occurred during 1,417 cases of left ventricular angiocardiography. No similar incident occurred with polyethylene pigtail or (dacron) Eppendorf and Gensini (style) catheters. In vitro comparison of hydraulic characteristics of polyurethane (Cordis) and polyethylene (Cook) pigtail catheters showed higher flow-pressure transmission through the tip of the Cordis polyurethane catheter favoring dislodgment of any existing clot. The problem of thrombogencity of polyethylene compared with polyurethane remains unsettled. Our experience with polyurethane pigtail catheters has resulted in limitation of their use in our laboratory.

Adult↗
PubMed1975

Coronary arteriography: prevention of thromboembolic complications using a pressure-drip flushing technique.

All selective coronary arteriographic examinations (1,833) performed in the authors' laboratory during a five-year period (1/1/70 to 12/31/74) were analyzed for mortality and total morbidity according to method used. During the first two years, the control period, the classic brachial artery cutdown (Sones) and percutaneous femoral artery puncture (Judkins) techniques were utilized. Mortality rate for the total 589 patients was 1.01%. This included a mortality of 0.26% (1/386) for the brachial arteriotomy method, and 2.5% (5/203) for the percutaneous femoral puncture approach. After introduction of the pressure-drip flushing technique, the subsequent three-year mortality rate for a total of 1,244 patients was 0.16%. This included an incidence of 0.17% (1/585) for brachial arteriotomy and 0.15% (1/659) for modified percutaneous puncture techniques. The morbidity incidence during the initial two-year period was 3.0% (18/589). This included an incidence of 2.0% for brachial arteriotomy and 5.0% for percutaneous puncture techniques. After institution of the new pressure-drip flushing technique the total incidence fell to 1.2% equally divided between arteriotomy and percutaneous techniques. Modification of the classic percutaneous femoral artery puncture techniques has resulted in major reduction of mortality and morbidity complications which are chiefly thromboembolic in nature. It has not significantly influenced local thrombotic complications of arteriotomy.

Angiocardiography↗
PubMed1975

Beneficial effect of hemodialysis on renal allograft survival.

The effect of the length of hemodialysis on the outcome of renal transplant was evaluated in 43 recipients of renal allograft. 22 out of 23 patients (95.7%) dialyzed for longer than one year had an excellent renal function at one year, while only 10 out of 20 patients (50%) dialyzed for less than one year had good renal function at one year. Only one kidney (4.3%) was lost due to rejection in the first group, while 10 kidneys (50%) failed to function because of severe rejection in the second group. The length of hemodialysis appears to have a beneficial effect on graft survival, but the mechanism by which it exerts this effect is not clear.

Adolescent↗
PubMed1975

Correlation in hemodialysis patients and renal allograft recipients between percent T lymphocytes in peripheral blood and in vitro lymphocyte responses to nonspecific mitogenic agents.

Both hemodialysis and renal allograft recipients have a significantly reduced number of total T lymphocytes per microliter of blood. Simultaneous in vitro lymphocyte responsiveness to phytohemagglutinin (PHA) and pokeweed mitogen (PWM) revealed in the normal subjects, a positive correlation (r = +0.427) between percent T lymphocytes and PHA and a negative correlation (r = -0.525) between percent T lymphocytes and PWM. Such trends were not observed in the hemodialysis patients and transplant recipients. Thus, the enumeration of lymphocytes as T cells appears to provide no clear indication of their functional capacity to respond to mitogenic stimulation in these two categories of patients.

Humans↗
PubMed1975

In vitro reactivity of lymphocytes obtained from uraemic patients maintained by heamodialysis.

Lymphocytes obtained from uraemic patients maintained on intermittent haemodialysis had a normal ability to respond to and stimulate allogeneic lymphocytes obtained from normal subjects in the mixed lymphocyte culture (MLC) reaction. The response of these uraemic lymphocytes to PHA and pokeweed mitogen (PWN) was also normal. Uraemic plasma from eight out of twenty-six patients studied, however, possessed blocking factor activity which suppressed the MLC reactivity of normal random donors and also the mitogenic response of allogeneic lymphocytes but not of autologous uraemic lymphocytes. The blocking factor activity was attributed to a non-dialysable factor present in the plasma of the patients investigated.

Adolescent↗
PubMed1975

Lymphocytotoxins and mixed leucocyte culture blocking factor activity in the plasma of uraemic patients undergoing haemodialysis.

Mixed leucocyte culture blocking factor activity (MLC-BFA) in the plasma of haemodialysis patients appears as a result of recent blood transfusions and is concentrated in IgG fractions of the blocking serum. Four patients neither developed lymphocytotoxins nor MLC-BFA in spite of having received multiple blood transfusions. Such 'unresponsive' recipients had an excellent clinical course upon receiving an allograft.

Blood Transfusion↗
PubMed1975

Mixed leucocyte culture blocking factor activity in allograft recipients and its role in the clinical outcome of human cadaveric renal allografts.

Seventeen renal allograft recipients were followed serially both pre- and post-transplantation for the presence of mixed leucocyte culture blocking factor activity (MLC-BFA) in their plasma. Patients could be divided into three distinct groups on the basis of MLC-BFA and lymphocytotoxin (LT) determinations. Fifteen out of seventeen patients possessed MLC-BFA at one time or another while four out of seventeen were positive for LT. Four patients of group 1 with pre-transplant LT and MLC-BFA rejected their grafts within 1 year. Two LT negative patients of group 2 developed no detectable MLC-BFA during a follow-up period of over 1 year. One other patient developed MLC-BFA 8 months following transplantation. All three patients had an excellent clinical course. Ten patients belonging to group 3 possessed no LT or MLC-BFA prior to transplantation but developed MLC-BFA alone after receiving an allograft. Only one patient rejected his allograft within 2 months. The remaining nine patients experienced mild rejection crises during the first 3 months after transplantation but had excellent renal function at 1 year or beyond that time. Our results indicate that MLC-BFA in the presence of LT may not prevent rejection. MLC-BFA is associated with a good clinical course in LT negative patients. However, certain patients who fail to develop LT or MLC-BFA in spite of repeated blood transfusions prior to transplantation may also do extremely well in the absence of detectible MLC-BFA.

Adolescent↗
PubMed1974

Mixed leucocyte culture blocking factor activity in the plasma of patients with cancer.

Plasma samples obtained from 74 patients with malignant disease were assayed for their ability to suppress or block the mixed lymphocyte reactivity of random normal donors. 24 of the 74 patients investigated had evidence of mixed lymphocyte culture blocking factoractivity (MLC-BFA). 19 of 33 patients with disseminated disease had evidence of MLD-BFA whereas in only 5 of 41 patients with localized disease was evidence of BFA found. There was a relationship between a history of previous blood transfusion inthe 6-month period prior to study and the presence of MLC-BFA in patients' plasma. Excluding this group of patients, where previous transfusion might have been responsible for MLC-BFA and excluding, too, that group of patients with a history of past pregnancy,there remained still 11 patients with evidence of BFA in their plasma. Nine of these11 had widely disseminated and progressiv disease. MLC-BFA was found in both IgM and IgG fractions of plasma. Plasma with MLC-BFA was found to suppress normalin vitro lymphocyte responses to mitogens PWM and PHA. The MLC-BFA assay utilized in this work may provide the means of monitoring cancer patients in order to detect 'blocking' antibody.

Antigen-Antibody Complex↗