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Biomedical subjects

A Rashid

Publications and source records attributed to A Rashid.

At least 127 records · Page 7Linked to original sources
PubMed1985

Clinical evaluation of a technetium-99m bone imaging agent based on the vicinal diphosphonate 1,2-diphosphonoethyleneglycol (DPEG).

From a series of technetium-99m labelled agents based on a vicinal diphosphonic acid structure, the ligand 1,2-diphosphonoethyleneglycol (DPEG) was selected for clinical study on the basis of a biodistribution in rats which compared well with that of methylene disphonphonate (MDP). The 99Tcm-DPEG agent was assessed in ten patients in whom bone metastases had been demonstrated by 99Tcm-MDP imaging two to seven days previously. Visual comparison of the skeletal images obtained with the two agents revealed the same number of bone metastases at the same locations. Statistical analysis of the data revealed no significant differences between the two radiopharmaceuticals on the basis of lesion to soft tissue ratio and lesion to normal bone ratio, although a slightly higher lesion to soft tissue ratio was found for MDP than for DPEG (p less than 0.03). At least for the formulation tested, it is concluded that this new radiopharmaceutical based on the P-C-C-P structure does not possess diagnostic advantages over 99Tcm-MDP for the detection of bone metastases.

Aged↗
PubMed1984

Subcutaneous technique for saphenous vein harvest.

A subcutaneous technique of saphenous vein harvesting is described, and the results of its use in 37 consecutive patients requiring two or more grafts are presented. The technique minimizes the handling of the vein and reduces leg wound complications and patient discomfort.

Coronary Artery Bypass↗
PubMed1983

Physical association of oestrogens and other steroids with DNA.

4C-Labelled mestranol, 3-O-methyl oestrone and cholesterol-5 alpha,6 alpha-oxide have been prepared. Along with the natural oestrogens, E1 and E2, and other steroids, these compounds have been used to determine the extent of their physical association with DNA. Analysis of binding both by equilibrium solubilization and by caesium chloride density gradient centrifugation showed the same relative order of binding: mestranol greater than 3-O-methyl oestrone greater than oestrone greater than cholic acid greater than cholesterol-5 alpha,6 alpha-oxide greater than progesterone, testosterone greater than oestradiol. DNA from Micrococcus lysodeikticus showed a higher affinity for cholic acid than did calf thymus DNA, while pretreatment of the latter with proteinase K somewhat reduced the level of physical binding of oestrone.

Animals↗
PubMed1983

Vitamin D state of Asians living in Pakistan.

Asians living in Pakistan have serum 25-hydroxycholecalciferol concentrations which are well within the normal range and significantly higher than in Asians resident in Britain. Clearly, Asians can maintain an adequate vitamin D state given an abundant supply of ultraviolet light, and the expression of vitamin D deficiency is an environmental and not a genetically determined characteristic. The risk of an Asian developing vitamin D deficiency increases after migration to Britain. The most efficient way to treat this is by supplementation with vitamin D.

Adolescent↗
PubMed1979

Familial urinary tract anomalies: association with the major histocompatibility complex in man.

Histocompatibility typing of a family with 15 members and a history of ureteropelvic junction stenosis and 4 families with 23 members and a history of vesicoureteral reflux revealed that these anomalies of the urinary tract may be hereditary and segregate with histocompatibility haplotype within a family. Thus, a close linkage of childhood reflux and ureteral stenosis with that of the major histocompatibility complex of man is suggested. If confirmed by further family studies it will place the gene(s) for vesicoureteral reflux and ureteral stenosis on the 6th pair of human chromosome and open the possibility of using histocompatibility typing as a marker for these anomalies within a family.

Adolescent↗
PubMed1979

HLA antigens in HBsAg infection.

The HLA typing of hemodialysis patients and normal subjects suggests a negative association of B8 and positive association of B5 with the development of anti-HBs and a negative association of BW35 with HBsAg antigenemia.

HLA Antigens↗
PubMed1979

Relationship of donor-specific mixed lymphocyte culture reactivity to graft function in recipients of cadaveric renal allografts.

The response of twelve cadaveric renal allograft recipients was serially studied in one-way MLC using the specific donor spleen lymphocytes as stimulating cells. The stimulation index (SI) progressively decreased between the second and the eighteenth post-transplantation week in the presence of normal plasma. The appearance of MLC non-reactivity (SI of less than 2.3) correlated well with the achievement of excellent graft function. In nine recipients allograft rejections have not occurred once the non-reactive state in cultures with normal plasma was established. In two of the recipients reactivity reappeared after an interval of non-reactive phase. In both instances rejection followed such reactivity and non-reactivity followed successful management of rejection. In one patient severe irreversible allograft rejection occurred in spite of the appearance of an early MLC non-reactive phase. This patient developed donor-specific lymphocytotoxic antibodies and his rejection was perhaps of antibody mediated type. Donor-specific MLC reactivity may represent cellular immune response of host to an allograft and predict cellular allograft rejection.

Adolescent↗