Biomedical subjects
A R Watson
Publications and source records attributed to A R Watson.
Placental localition by thermography.
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The economic significance of respiratory diseases in the Victorian chicken meat industry.
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Nutritional myopathy--a cause of ataxia in broiler chickens.
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Guidelines by an Ad Hoc European Committee for Elective Chronic Peritoneal Dialysis in Pediatric Patients.
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Renal osteodystrophy in children on CAPD: a prospective trial of 1-alpha-hydroxycholecalciferol therapy.
The efficacy of 1 alpha-hydroxycholecalciferol in the prevention of renal osteodystrophy in children commencing continuous ambulatory peritoneal dialysis was studied in 12 patients, 0.8-17 years of age, who were randomly assigned to either group I receiving standard therapy or to group II receiving in addition 10-20 ng/kg body weight/day of 1 alpha-hydroxycholecalciferol. Calcium carbonate compounds were used to control hyperphosphataemia. Mean plasma calcium (total and ionised) and phosphate levels were not significantly different between the two groups. All group I patients continued to have elevated plasma immunoreactive parathyroid hormone levels at 6 months compared to only 1 patient in group II (p less than 0.05). Four patients in group I developed subperiosteal erosions on radiography compared to the healing of mild lesions in 2 patients in group II. Bone histomorphometry on iliac crest needle biopsy specimens revealed a significant reduction in osteoid index and seam width in group II. Serum aluminum levels decreased during the course of continuous ambulatory peritoneal dialysis, and the significant staining for bone aluminum in 6 patients at the beginning of the study was no longer present in 5 patients at 6 months. Our data demonstrate that 1 alpha-hydroxycholecalciferol is beneficial in the prevention and treatment of bone disease in children on continuous ambulatory peritoneal dialysis.
Chronic renal failure in childhood.
Chronic renal failure in childhood is associated with diverse renal conditions, and the progression to end-stage renal failure requiring dialysis and transplantation may be ameliorated by close attention to blood pressure control, correction of metabolic abnormalities and expert dietetic advice. The morbidity has been improved by the availability of vitamin D analogues, erythropoietin and growth hormone. Dialysis and renal transplantation are possible at any age in specialist centres.