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Biomedical subjects

A Poppi

Publications and source records attributed to A Poppi.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Vectorcardiographic contribution to the differential semeiology of cardiomyopathies (author's transl)].

The electro-vectorcardiographic findings of 59 patients with idiopathic cardiomyopathies, divided by means of hemodynamic and angiographic study into dilated (38 cases), hypertrophic obstructive (10 cases) and hypertrophic non obstructive (11 cases), were compared with those of a control group of 17 patients with left ventricular hypertrophy of known etiology. The statistical vectorial analysis of the 4 groups, excluding the patients with intraventricular conduction disturbances and patients below 10 years of age (46 cases), showed low voltage of the first vectors, especially at 0,01 sec., in the obstructive compared with the non obstructive type. On the basis of the data from the literature on histological findings in cardiomyopathies, these differences can be interpreted as due to a different myofibrillar arrangement in the free wall of the left ventricle.

Arrhythmias, Cardiac↗
PubMed1975

[Intra-aortic balloon counterpulsation: first clinical experiences (author's transl)].

Three cases of acute myocardial infarction treated with intra-aortic balloon counterpulsation (IABP) are reported. In the first patient cardiogenic shock and pulmonary oedema were the complicating features; the second one had pulmonary oedema refractory to medical treatment. Both patients promptly improved, shock and heart failure having been reverted to clinically satisfactory conditions. Nevertheless the first patient could not be weaned efficiently and died on the sixth admission day. A huge myocardial involvement was found autoptically. The second patient died on the third day mainly because of a haemorrhagic complication. The third patient started the treatment with IABP at the 68th hour because medically unresponsive left heart failure and persisting ECG signs of widespread myocardial ischemia. Improvement of haemodynamic parameters and disappearance of subepicardial lesion were achieved. Eventually this patient was discharged on the usual rehabilitation regimen.

Acute Disease↗
PubMed1975

A multicenter double blind clinical trial on 3.4.5-trimethoxybenzoiyl-epsilon-aminocaproic acid (C-3) in acute myocardial infarction.

186 out of 391 patients with acute myocardial infarction were treated with C-3 and 205 with placebo in a multicenter, double-blind clinical trial. Ensuing complications were treated in the same way in both groups. C-3 was injected i.v. slowly at the dose of 2 g statim plus 6 g by continuous drip infusion over 24 hrs for 5 days. During treatment, clinical progress was influenced only in regard to cardiac failure since in the C-3 group the improvement was more significant than in the placebo one (P less than 0.0025). Mortality rates were 8.1% and 11.2% for the C-3 and placebo groups, respectively. The difference in mortality was significant (P less than 0.05) for patients treated with C-3 for more than 24 hours. Mortality in male patients treated with C-3 for more than 12 hours was significantly lower (P less than 0.025). In patients less than 60 years old mortality rate was significantly lower (P less than 0.05) and was more so in patients receiving C-3 for more than 12 hours (P less than 0.025). Mortality due to complications was lower in the C-3 group, with arrhythmias (9.8% vs 14.2%), cardiogenic shock (69.2% vs 75%), and cardiac failure (9% vs 19.4%). Results agree with the hypothesis that C-3 may be effective in acute myocardial infarction by improving the action of traditional antiarrhythmic drugs, and augmenting myocardial contraction energy.

Acute Disease↗