[Acute myocardial infarct in the female sex: incidence, mortality and causes of death].
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Biomedical subjects
Publications and source records attributed to A Poppi.
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Ten patients with angiocardiographic and hemodynamic evidence of discrete subvalvular aortic stenosis were examined by M-mode-echocardiography. Different echocardiographic patterns were identified: the most frequent appeared an abnormal systolic movement of aortic valve leaflets, less frequently a discrete linear echo was observed in the outflow tract of the left ventricle; in one case the echocardiogram showed no abnormality of the left ventricular outflow tract or aortic valve morphology. In half of the cases the left ventricular outflow tract was narrowed. No correlation was found between echocardiographic measurements and severity of the subaortic lesion, as expressed by peak systolic pressure difference between the left ventricle and the aorta. It is concluded that M-mode-echocardiography: - may furnish helpful criteria in the diagnosis of discrete subaortic stenosis, but the absence of such criteria does not allow to exclude the existence of the malformation; - is not quantitatively useful in the assessment of subaortic stenosis.
The AA. relate the results of an echocardiographic study carried out on some patients with mitral stenosis associated or not with mitral regurgitation or with other valvular disease. Ten patients who had to undergo to surgical commissurotomy, were studied before and in the early post-operative period. The M-mode echocardiography appeared to be always available to diagnose the mitral stenosis, but not to quantify it. On the other side the two dimensional echocardiography is proven to be a useful method in the quantitative study of the mitral area and particularly when it is applied in the evaluation of the surgical results of comparing the pre and post-operative examinations. The data obtained were analysed with statistical method.
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The echocardiogram is able to diagnose on which valvular leaflet or cusp the bacterial vegetations are implanted; it is also able to recognize the type of lesion (destroying vegetations, prolapsing vegetations, etc.). In our experience the echocardiographi findings were fully confirmed at surgical intervention in 12 of the 13 patients studied.
In 20 patients, who had undergone a routine cardiac catheterization for the evaluation of anginal syndrome, some parameters of mechanical function of left ventricle (LV) were evaluated before and after left ventriculography was performed. Then, the same parameters were also measured, in identical technical conditions, after the administration of 20 mg of sublingual nifedipine (NIF). After NIF a significant decrease (P < 0.01) in left ventricular systolic and diastolic pressure, aortic diastolic pressure and left ventricular enddiastolic and endsystolic volumes was observed; while, heart rate, dP/dt max, stroke volume and ejection fraction were significantly increased (P < 0.01). Evaluation of LV segmental wall motion, after NIF, revealed no changes of wall motion in normal areas or in those with akinesis or dyskinesis; while, 68% of the areas with slight hypokinesis and 55% of those with severe hypokinesis were significantly improved after NIF (P < 0.005). Thus, we concluded that NIF does not cause a depression of LV mechanical function. The improvement of LV wall motion displayed by the areas with a transitory ischemic damage could be attributed to the reduction in preload and, more significantly, in afterload induced by NIF.
On the hypothesis that encroachment on left ventricular performance by postinfarction aneurysm (An) is related to its size, a method was investigated for the measurement of aneurysmal dimensions. On radioopaque plastic casts grossly ellipsoidal in shape with addition of masses in different position to simulate aneurysms, satisfactory data for volume calculation were obtained by the association of the ellipsoid formula applied to the contractile portion with the formula of the hemispheroid applied to the aneurysmal section, the difference between real and calculated volumes being not more than +/-5%. In 100 Pts. with previous myocardial infarction, showing at ventriculography akinetic-diskinetic segments of the left ventricular wall, the absolute volume of An and its percentage value of the total left ventricular volume (V An%) were measured. A statistical correlation was studied with other hemodynamic and angiographic parameters of left ventricular function. Cardiac index and angiographic stroke volume decreased with increasing V An%, but with a low correlation, of no statistical significance; only for An with a volume of 60% or more C.I. and SV were constantly reduced. The LVEDP, higher than normal in 80% of the cases, rose with increasing V An%, but with a correlation of low statistical significance. The EDV increased progressively and significatively with increasing V An%, resulting therefore in relation with the extension of noncontracting segment.
2 patients, aged 8 mth and 48 yr, referred for a clinical diagnosis of ventricular septal defect, were studied by ultrasound. In both a fluttering and an anterior bowing of the systolic segment of the tricuspid valve was found, consistent with a left ventricular--right atrial communication. Diagnosis was confirmed by angiography and open-heart surgery, showing in 1 patient a supravalvular defect, and an infravalvular one in the other. The postoperative echocardiograms of the tricuspid valve were normal. Ultrasound appears to be a safe and simple method in detecting this rare cardiac abnormality.
In 120 P. with ischemic heart disease, left ventricolar wall motion was analyzed from the left ventriculogram in a regular sinus beat as compared to the first beat following one or more premature ventricular contractions (PExP). The response of asynergic segment to PExP was determined with a qualitative as wall as a quantitative technique. Of a total of 225 asynergic segments, 62% showed a positive response to PExP. In the absence of pathologic Q waves in the electrocardiogram, the response was positive in 77% and negative in 23% of the cases. In the presence of Q waves, PExP was present only in 33% of the cases (p less than 0.001). In respect to the severity of asynergy, 68% of 145 hypokinetic segments and 52% of 80 akinetic-dyskinetic segments responded to PExP; in the presence of pathologic Q waves, the number of positive responses decreased to 36% in the case of segmental hypokinesis, and to 31% in the case of more severe asynergy. The study of PExP has appeared as an useful diagnostic technique, capable of detecting a residual myocardial function in left ventricular asynergic segments, even in the presence of electrocardiographic signs of infarction.
95 angina patients surgically treated by aortocoronary saphenous vein by-pass, have been studied by comparing the factors limiting the exercise (i.e. muscular exhaustion, angina, electrocardiographic changes), the total work performed, the O2 consumption and the heart rate-arterial pression product. After surgery the incidence of positive effort tests (effort angina and/or ecg evidence of myocardial ischemia) decreased from 79% to 27,4% (p less than 0,001), and the average amount of work performed increased from 2718 to 3504 Kgm (p less than 0,01), the MVO2 from 13,9 to 15,6 cc/min/Kg. (p less than 0,01) and the heart rate-arterial pression product from 206 to 243 (p less than 0,001). The patients who preoperatively were more invalidated (that is able to performe a lasser amount of physical work) presented a more pronounced improvement in comparison with those who had a greater tolerance to exercise. It seems therefore that for these latter patients the bypass grafting surgery should be justified only if a significant increase of life expectancy and reduction of myocardial infarction incidence could be definitely proved. The exercise performance improvement after surgery was statistically significant only in the patients with post infarction or with unstable angina not in those with chronic angina. The perioperative infarction (present in 8,4% of cases) did not show any unfavorable correlation with the result of the late postoperative effort test.
In 10% of cases of mitral stenosis the echocardiogram shows a normal backward movement of the posterior mitral leaflet. On the basis of a personal observation the authors suggest that this atypical pattern is related to the type (commissural) and degree (slight) of the valvular involvement.
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The Authors promoted an inquiry, to all the General Practitioners in the Province of Verona about the problems the patient with a pacemaker implanted bears to his attending physician. The results of this inquiry have shown uncertainties or faulty beliefs about the follow-up and medical treatment of the patients with pacemaker. Therefore the work has shown the necessity of a closer connection between hospitals and general practitioners in order to provide continuous medical education on this problem.
Electric and mechanical atrial paralysis is a condition usually associated with a primitive or secondary cardiopathy. Only extremely rare cases are characterized by early appearance in young subjects without evidence of cardiac disease of any kind whatever, without character of familiarity, with atrial paralysis being the only abnormality, and are thus defined as idiopathic atrial paralysis. One of these cases (the eighth in the literature, to our knowledge), presented with a complete study and the hypothesis that "chronic idiopathic atrial paralysis" and "idiopathic right atrial enlargement" (sometimes associated, as in this case) may be different manifestations of the same chronic myocardial disease.
In 100 consecutive patients, subjected to myocardial revascularization by aorto-coronary saphenous vein bypass grafting with a standard technique, several clinical, hemodynamic and angiographic data were studied in correlation with the short-term prognosis. The operative mortality (6% on the whole) appeared to be strictly correlated with the degree of left ventricular impairment. Among the considered hemodynamic indices (LVEDP, CI, EDV, EF), EF was the most significant one: mortality was 0% if EF was normal, but raised to 15 and 40% respectively, when this was moderately or severely reduced. The operative risk was heavily aggravated if 4 or more indices of left ventricular impairment were present, mortality being 45% versus 1% in patients with abnormality of 3 or less parameters. The extension of coronary artery involvement proved to be a lesser prognostic factor than the degree of complements of the surgical revascularization. No correlation was found between the preoperative value of the hemodynamic parameters and the incidence of perioperative myocardial infarction (18% in the total series).