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Biomedical subjects

A Popov

Publications and source records attributed to A Popov.

At least 91 records · Page 5Linked to original sources
PubMed1977

[Morphology of the spleen and immune response in experimental nutritional deficiency in rats].

The author examined 60 white rats of the strain "Wistar" with initial age of four months and body weight of 180--220 gm, subjecter to nutritive deficit regimens with various protein content. He described the morphological changes in the spleen, made a qualitative analysis of IgG and IgM in serum and examined also some links of the immune response after antigen stimulation with human gamma-globulin. Very limited nutrition (5,74 of protein) for 16 weeks caused immune deficit with definite morphological substrate-atrophy and fibrosis of the lymphoid tissue. Moderate limited feeding (11, 48% of protein) did not induce substantial deviations from the functions the immune system.

Animals↗
PubMed1976

[Structuro-functional parallels in several liver lesions in rats resulting from dietary protein deficiency].

The authors examined 60 white rats of the Wistar strain with initial age of four monts and weight of 200 -- 15 gm, subjected to deficient food regime with varous protein content (5.74%, 11.48%, but the control was 17.50% of protein) for a period of 16 weeks. After this period half of the animals were stimulated by an antigen -- 10% of human gamma globulin. They determined total protein and protein fractions in serum, histological changes in liver and some morphometric indices. It was established that there was a correlation between the level of serum proteins and the observed changes in liver parenchyma and mesenchyma, in which the factor "protein deficit" had significantly greater effect than the factor "heterologous serum protein" as an antigenic stimulus.

Animals↗
PubMed1976

[Morphological changes in the organs of rats subjected to limited feeding and physical loading].

Changes in the liver, stomach, small intestine, kidneys, lungs, myocardium, aorta, spleen and mesenterial lymph nodes are studied histologically in 120 male white rats from the Wistar line, subjected to a deficient alimentation regime, with and without physical exertion. The observed slight degree of adiposogenital dystrophy of the liver during free feeding regime indicates that the latter is equivalent to overfeeding. Variations from the normal histological picture in some organs (liver, myocardium, stomach and small intestine) are detected in the groups undergoing rather prolonged, moderate undernourishment--a sign of the sensitivity of these organs to the limited supply of nutritive ingredients. Physical loading, combined with free alimentary regimen, exert a beneficial effect on the organism which is suggested by the morphological data disclosing a slightly enhanced function of the myocardium and kidneys in these animals.

Animal Nutritional Physiological Phenomena↗
PubMed1976

[Lysosomes, cellular digestion and immune processes].

The article presents a survey of the available literature concerned with the problems of relationships between the functions of the lysosomal apparatus of cells of the reticuloendothelial system and immune processes. A connection between the primary lysosoma and endocytic vacuole, desintegration of absorbed antigens by micro- and macrophages, the significance of antigenic information transmitted by macrophage to an immune lymphocyte, and realization of the immune response are traced carefully and in succession. Participation of lysosomas in antigen-antibody reactions (anaphylaxis, Arthus' phenomenon, supersensitivity of a delayed type) and their role in induction of immune tolerance and in some autoimmune processes are also considered.

Acid Phosphatase↗
PubMed1975

[Free and bound sterol content of sunflower, soy bean and maize oils].

The amounts of free sterols, steryl esters and steryl glycosides in sunflower, soya and maize oils as well as in the phosphatides of the same oils were determined. The refinement byproducts were enriched with sterols. The highest contents of total sterols and steryl glycosides (2,68 and 1,9%, respectively) were established in soya phosphatides followed by those in sunflower oil phosphatides (2,03 and 1,68%, respectively) and maize oil phosphatides (0,81 and 0,54%, respectively).

Dietary Fats↗
PubMed1975

An injury-induced diffuse slow potential from brain.

Three different slow potential (SP) changes resulting from focal brain injury are described. The first is an immediate, high amplitude (in excess of 25 mV)negative shift at the site of injury. The second is a biphasic negative-positive SP wave which spreads throughout the cortex ipsilateral to injury and is similar to spreading depression (SD). The third SP change, called here the injury-induced diffuse slow potential (IDSP)is a prolonged (lasting approx. 2h) negative shift occurring simultaneously in many brain areas, also in those far removed from the injured focus. The SD can be separated from IDSP by the size of focal injury; a 20 mu pucture of the parenchyma will trigger IDSP but not SD. An injury resulting from a larger puncture triggers both, SD and IDSP. IDSPcan not be induced by a re-entry of a previously damaged tissue. The magnitude of IDSP has anatomical specificity in that the largest amplitude occurrs in white as compared to gray of the cortex or of the caudate nucleus. Aso, the magnitude of the hypothalamic IDSP is larger when ipsilateral corpus callosum-commissural regions are injured. Electrical stimulation of the cortex in rats sufficiently strong to result in tonic-clonic convulsions triggers SD and IDSP; these two slow potential changes are similar to those induced by mechanical injury. A transpinnate electrical stimulus strong enough to elicit a grand-mal type of discharge results in a diffuse negative slow potential change similar to IDSP elicited by mechanical damage or direct cortical stimulation.

Animals↗
PubMed1975

[Morphological changes in the internal organs and endocrine glands of rats subjected to deficient nutrition and fasting].

Pathological studies on the internal organs, endocrine glands inclusive, are carried out in white rats under conditions of deficient alimentation and fasting. The results of the study show that complete starvation with preceding full value or restricted (2 hours daily) feeding brings about a variety of morphological reactions in the internal organs and endocrine glands. The liver proves to be the most sensitive to reduced food supply it shows a marked response with fatty dystrophy and subsequent atrophy. Next ranks the kidney. Myocardium, spleen, thyroid gland, adrenals and testes fall in the third group--with a weaker and rather delayed response. Small intestine, lung and hypophysis do not show changes worth noting. The investigations performed are related to the effect exerted by starvation and deficient nutrition, assumed as a stress factor for the organism.

Adrenal Glands↗