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Biomedical subjects

A Pau

Publications and source records attributed to A Pau.

At least 73 records · Page 4Linked to original sources
PubMed1988

[New derivatives of 7-amino-2,3-polymethylenindole with anti-inflammatory activity].

Thirty-four new N-acylderivatives of 7-amino-2,3-polymethyleneinoles (I) and (II) were prepared and tested, together with a few analogues previously obtained, against carrageenan edema in the rat. Several compounds, at a dose of 1 mmole/kg, exhibit good inhibitory activity, that in some cases is superior to that displayed by indomethacin at a dose of 5 mg/kg. With only one exception, activity is confined to compounds of formula (I) and, generally, derivatives of 2,3-hexamethyleneindole are more active than those of lower homologues.

Animals↗
PubMed1987

Axonal elongation into peripheral nerve grafts between thalamus and somatosensory cortex of the rat. An experimental model.

After destruction of the thalamocortical projections of one side in 12 adult rats, the ipsilateral thalamic ventrobasal nucleus was connected with the contralateral somatosensory cortex through an autologous peripheral nerve graft. Three months after the implanting procedure, horseradish peroxidase was applied to the transected nerve. Retrograde labeling of cells occurred in all examined animals. Evidence of newly formed thalamocortical connections provides the experimental basis to a model suitable for functional evaluations.

Animals↗
PubMed1987

Computed tomography and magnetic resonance imaging in spinal hydatidosis.

Computed tomography and magnetic resonance imaging in patients with spinal hydatidosis provide comprehensive evaluation of the actual extent of the disease. Paravertebral uncalcified cysts, hardly recognizable by conventional radiologic examinations, are clearly shown by both methods. Initial involvement of the spongy bone is evident in computed tomography scans, in contrast to what usually appears to be normal in plain films or tomograms. Occurrence of cysts within the spinal canal is revealed by both types of computed scans, with magnetic resonance imaging being able to provide further information on the involvement of the spinal cord.

Adult↗
PubMed1987

Computed tomography and magnetic resonance imaging of cerebral coenurosis.

A case of Coenurus cerebralis involving both cerebral hemispheres and the interpeduncular cistern is presented to illustrate the computed tomography (CT) and magnetic resonance imaging (MRI) features. In CT scans viable cysts appear as lucent lesions surrounded by a contrast-enhanced peripheral rim. By using multiple echo sequences the cyst content is characterized in magnetic resonance images by a cerebrospinal fluid-like intensity pattern.

Brain Diseases↗
PubMed1986

[Anatomo-surgical classification and surgical treatment of arteriovenous malformations in the posterior cranial fossa].

An increasing number of arteriovenous malformations of the posterior cranial fossa can be radically extirpated with good functional results, by using microsurgical techniques. Extensive involvement of the brain stem represents the limit for effective surgery. An anatomo-surgical classification of these lesions is presented, and the surgical indications are discussed.

Brain Neoplasms↗
PubMed1986

[Echinococcosis of the spine].

21 patients with hydatid disease of the spine were operated on upon a 30-year period. The follow-up ranged up to 24 years. 12 cases underwent one or more reoperations, due to recurrences. 8 patients died between 1 and 21 years after the first operation. The surgical treatment usually allows only a transient remission and does not avoid recurrence or progression of the illness. Although the parasite cannot be wholly eradicated surgically, a prolonged and acceptable life with the disease can result from repeat surgical interference.

Echinococcosis↗
PubMed1985

Partial ventricular dilatation contralateral to chronic subdural haematoma.

In a series of 88 cases of chronic subdural haematoma, the occurrence of dilatation of the posterior portion of the contralateral ventricle was found to be unrelated to any major neurological variable. There was, however, a prevalence of recurrences of the subdural effusions in the patients with partial hydrocephalus, compared with patients without ventricular dilatation.

Adolescent↗
PubMed1985

Long-term results of surgical treatment for redundant roots of the cauda equina.

Seven patients with redundant roots of the cauda equina were followed 2 1/2-10 years after surgical decompression. Improvement of signs and symptoms occurred in all patients. However, none of them was neurologically intact at the time of the last physical examination, although persistence of minimal neurological signs and/or occasional pain did not prevent a useful occupational activity.

Adult↗
PubMed1985

Cerebral blood flow in minor cerebral contusion.

Seventeen patients with minor cerebral contusion were selected from a series of patients with head injuries of various severity, who had undergone repeat evaluations of the regional cerebral blood flow. The mean global flow (expressed as mean global initial slope index) on early examination was found to be significantly lower, compared with that recorded in healthy volunteers. A tendency towards the recovery of higher flow values was apparent in repeat evaluations that were performed several weeks after the injury. Interhemispheric asymmetries of flow were a common occurrence, with lower perfusion and reduced attenuation values on computed tomography scans being, however, in good agreement only in approximately half of the cases.

Adolescent↗
PubMed1984

Effects of age on the clinical pharmacokinetics of ibuprofen.

The pharmacokinetics of ibuprofen (Motrin) were studied in 17 normal elderly men and women aged 65 to 78 years. Total and free unbound plasma concentrations of ibuprofen were determined 12 hours after single oral doses of 400, 800, and 1,200 mg. These results were then compared with those of a similar study involving 15 normal young men 22 to 35 years old. The two age groups showed no statistically significant differences in any pharmacokinetic parameter studied. Therefore, according to this study, advanced age has only minimal influence on the pharmacokinetics of ibuprofen, and dosage apparently does not need to be adjusted for age.

Adult↗
PubMed1984

Subchoroidal approach to the third ventricle. Microsurgical anatomy.

The third ventricle can be approached by performing a few surgical maneuvers: (a) dividing the ependyma on the inferolateral aspect of the choroid plexus of the lateral ventricle; (b) separating leptomeningeal bundles within the tela chorioidea, and (c) dividing the roof of the third ventricle along the stria medullaris. Main landmarks are the thalamostriate vein and the direct lateral vein. Small subependymal veins or neural branches of the posterior medical choroidal artery, or both, occasionally cross the access route. The third ventricle is seen through both the opening in the roof and the foramen of Monro. A wider exposure can be obtained by cutting the terminal segment of the thalamostriate vein.

Cerebral Ventricles↗
PubMed1984

Redundant nerve roots of the cauda equina.

The authors have critically reviewed 8 cases which have come under their observation of a lumbosciatic syndrome due to redundant nerve roots of the cauda equina. Some of the clinical and myeloradiculographic features appear to be characteristic of this rare syndrome. Surgical intervention by decompressing the nerve roots of the cauda equina offers a very favourable prognosis.

Acute Disease↗
PubMed1984

3H-leucine incorporation into subcellular fractions of human brain tumors.

In vitro incorporation of 3H-leucine into proteins of subcellular fractions of brain tumors has been investigated. Protein-bound radioactivity of nuclei and soluble fraction significantly increased compared to values of the normal brain. Moreover, the study demonstrated that microsomes, the most active fraction in protein synthesis in the normal tissue, always showed lower values than neoplastic nuclei. The pattern of 3H-leucine subcellular uptake obtained in brain tumors might suggest some similarities to that seen in the early phases of brain maturation.

Astrocytoma↗
PubMed1983

Omental transposition or transplantation to the brain and superficial temporal artery--middle cerebral artery anastomosis in preventing experimental cerebral ischaemia.

Transposition of lengthened omentum to the brain surface, transplantation of an omental graft, or superficial temporal artery--middle cerebral artery anastomosis were performed in dogs prior to transcranial occlusion of the ipsilateral middle cerebral artery at its origin, including the bifurcation of the internal carotid artery. Both omentum and by-pass were able to reduce the changes in cerebral blood flow, somatosensory evoked responses, cerebral water and electrolyte content, consequent to the ischaemic insult. In the experimental conditions adopted in this study, the effect of omental transposition in maintaining high levels of flow throughout the entire occluded hemisphere was more marked compared to that resulting from the other methods, while the onset of ischaemic cerebral oedema was affected approximately at the same degree by all procedures. The results point to the role of the transposed omentum in providing an effective collateral circulation to the ischaemic brain.

Animals↗
PubMed1982

Mobile neurinoma of the cauda equina. Case report.

A mobile neurinoma arising from a redundant nerve root of the cauda equina is reported. The abnormal length of the nerve root allowed the neoplasm to move in the cranio-caudal direction along two segments of the spine.

Cauda Equina↗