Nifedipine and Prinzmetal's angina.
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Biomedical subjects
Publications and source records attributed to A Palant.
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86 patients with ischaemic heart-disease were assessed for the presence of the MB isoenzyme of creatine kinase (C.K.-MB). Raised C.K.-MB levels with normal total C.K. were found in 10 patients with a clinical picture, but no electrocardiographic evidence, of acute myocardial infarction. 4 of these patients later had an infarction, but the remaining 6 have remained undiagnosed. Of 26 patients with unstable angina, 11 (42%) had high levels of C.K.-MB in the presence of normal total C.K. Of 50 patients with effort angina and a positive ergometric stress test, 3 (6%) with crescendo angina had high C.K.-MB levels in the presence of normal total C.K. In patients with angina, myocardial necrosis was excluded by normal serum-myoglobin levels. In both groups with angina, those with raised C.K.-MB levels had a more severe clinical picture, greater depressions of the ST segment, and lower threshold to ergometry. Raised C.K.-MB levels may indicate myocardial ischaemia.
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Two patients with pulmonary hydatid embolization are described and commented upon in the light of 43 similar published cases. The diagnosis was strongly suspected from the medical history and the chest x-ray films and supported by angiocardiography. The angiocardiographic features of this condition have not been described previously in detail. They include amputation and filling defects of pulmonary artery branches, which are typically located proximal to a rounded tumour-like opacity seen on the plain x-ray film. Both patients underwent successful embolectomy.
In two patients with a clinical picture of acute mitral insufficiency, the presence of chordal rupture secondary to myxomatous degeneration of the mitral valve was disclosed during surgery. There was no evidence of previous rheumatic valvulitis, subacute bacterial endocarditis or other etiologies. It appears from the literature and from the cases described that ruptured chorda tendinea is a not uncommon complication of myxomatous transformation of the mitral valve. While this fact has been mentioned in anatomophological reports, clinicians are less aware of the association. In the absence of supportive evidence for a rheumatic or arteriosclerotic etiology, a clinical picture of acute mitral insufficiency should suggest ruptured chorda tendinea secondary to myxomatous degeneration of the mitral apparatus. This is particularly true in older patients, especially among those followed for a midsystolic click-late systolic murmur or an apical pansystolic murmur of pure mitral regurgitation.
A rare case of telangiectatic communication between the conal branch of the left coronary artery and the pulmonary trunk in a 50-year-old woman is reported. Unusual features included the presence of clear-cut angina on effort, unstable auscultatory findings and a RSR' pattern in lead V1, probably related to concommitant diffuse coronary atherosclerosis. Ten previously reported cases of the condition are briefly reviewed.
Multiple anomalies of persistent left superior vena cava and left hepatic vein emptying into the left atrium associated with atrial septal defect, right aortic arch and multiple skeletal malformations are presented. The anatomy and the embryology of these anomalous venous connections are briefly reviewed. Clinical, hemodynamic and surgical implications of these anomalies are discussed.
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A 56-year-old man with the Wolf-Parkinson-White (WPW) syndrome (type A) is described. His presenting signs were paroxysmal atrial tachycardia and fibrillation induced by swallowing. This supraventricular tachyarrhythmia (SVT) could be abolished by performing the valsalva maneuver or carotid stimulation, and prevented only by treatment with amiodarone.
The case of a 74-year-old woman with toxic thyroid adenoma, presenting as complete heart block, is described. Upon admission the patient was in a state of circulatory collapse with metabolic acidosis and hyperkalemia. After initiation of right ventricular pacing the circulatory and metabolic disorders rapidly normalized without any other specific therapy. Since treatment and attainment of the euthyroid state the patient has had no conduction delays or arrhythmias. Complete heart block in thyrotoxicosis is uncommon and previous reports relate to its occurrence in Graves' disease, usually complicated by infectious disorders. This is the only case known to us of complete heart block in toxic thyroid adenoma.