Search PubMed⌕ Search

Biomedical subjects

A P Forrest

Publications and source records attributed to A P Forrest.

At least 145 records · Page 8Linked to original sources
PubMed1978

Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.

The relationship between oestrogen-receptor protein (ER) content of the tumour and the response to endocrine therapy was determined in 119 patients, in a collaborative prospective study. Twenty-eight of the 80 patients with measurable ER responded to treatment according to UICC criteria, compared with only 3/39 without ER. It was found that site of biopsy did not influence the result, but tumour content of the tissue sample was significantly related to the presence of receptors. The organizational problems of such a study are discussed.

Breast Neoplasms↗
PubMed1977

[Treatment of breast cancer (author's transl)].

Controlled trials and long term studies in patients with breast cancer of stage I and II have shown, that this disease in the majority of cases is no longer localized when first noticed clinically. Surgical therapy is therefore only a part of the complete management of these patients and must be thought over concerning its radicality. In England several controlled studies are under way for that reason. They are conducted and continuously evaluated by multidisciplinary teams of which the surgeon is an important member.

Biopsy↗
PubMed1977

Conservative local treatment of breast cancer.

A survey of controlled randomized trials of orthodox therapy directed to the breast and axillary nodes has indicated that 1) if radical mastectomy is performed, postoperative radiotherapy gives no advantage over a watching policy and 2) if postoperative radical radiotherapy is given, there is no need for other than a simple mastectomy. A large multicenter trial is also indicating that simple mastectomy alone with reservation of radiotherapy for treating local recurrent disease is safe initial treatment. These results refer to survival; postoperative radiotherapy does reduce the incidence of local recurrence but this apparently can be equally well treated when it occurs. Local excision of the tumor, followed by radiotherapy, has been reported to give inferior results to a radical approach in Stage II tumors. Recognition that all these methods of local treatment fail to cure the majority of patients has emphasized the need to define the extent of the disease and to apply treatment according to that extent. We have studied a policy of selective local therapy based on this principal in which total mastectomy is combined with biopsy of the pectoral lymph nodes and further treatment by radiotherapy given only if these nodes are involved by tumor. This policy has been compared with a standard radical approach and is giving similar results. In our current Edinburgh trials, pectoral node biopsy is also used to select patients for inclusion in trials of systemic therapy.

Breast Neoplasms↗
PubMed1977

Breast screening and surgical problems.

The Edinburgh Breast Screening Clinic in its first year completed the initial screening examination of 3005 invited women, who were apparently in good health, aged between 40 and 60 years; 141 were referred for a surgical opinion; 70 women ultimately underwent biopsy and 9 proved to have carcinoma. The indications for biopsy are described together with methods of management of the various lesions.

Adult↗
PubMed1977

Reproducibility of measurements of oestrogen-receptor concentration in breast cancer.

The reproducibility of measurements of oestrogen-receptor activity has been examined in multiple specimens from a rabbit uterus, a rat mammary tumour and human breast tumours. The relationship between receptor concentration and tumour histology has also been investigated in 11 large primary tumours. In the animal tissues, receptor measurements were relatively reproducible (coefficient of variance: wet wt. basis 16-17%, protein basis 16-21%) but in human breast tumours receptor activity varied considerably (c.v.: wet wt. basis, 22-125%; protein basis, 28-72%). In addition to these variations in receptor activity within tumours, there was a difference between tumours, as demonstrated by an analysis of variance (P less than 0.01). In the 11 primary breast cancers selected for study, the level of receptor activity was related to menopausal status and the tumour content of the specimen. We conclude that the receptor activity detected varies within a tumour and depends upon the tumour content of the biopsy specimen. Predictions based on precise quantitation of receptor concentrations may therefore necessitate replicate tumour sampling and correction for the fraction of non-tumour tissue in each sample.

Animals↗
PubMed1976

Circulating hormone concentrations in women with breast cancer.

Multiple plasma-hormone concentrations were measured in sequential plasma-samples from six women with breast cancer and were compared to concentrations in six control women matched for age, years since menopause, and parity. All hormone concentrations in all the women studied were within normal limits. However, within the normal range the plasma-testosterone concentrations in each cancer patient were significantly higher than in each matched control.

Age Factors↗
PubMed1976

Simple mastectomy and pectoral node biopsy.

Evidence is presented to support the view that biopsy of the pectoral and axillary tail nodes obtained at simple (total) mastectomy gives a reliable estimate of axillary node status. The technique is described.

Axilla↗