It has been postulated that stress induces discorrelations of the hypothalamo-pituitary and pituitary gonadal axis. In our experiments on the effect of stress on the reproductive physiology in rats and sheep we applied mild electrical footshocking of short or prolonged duration. Foot-shocking applied with some breaks during 9 h within one a day (15th day of the oestrous cycle) induced in ewes acceleration of the release of LH. Prolonged footshocking applied with some breaks during 3 days in cycling sheep caused disturbances in the circadian rhythm of the cortisol secretion, disturbances in the release of LH and led to the blockade of ovulation. Disturbances in the course of oestrous cycle occurred not only during the current cycle but also during two subsequent cycles. Rats exposed to relatively long-term stressful situation (24 h) during dioestrous displayed marked changes in the length of this phase in three subsequent post-stress oestrous cycles. To follow the neurohormonal background of the stress-induced disturbances in LH release and in the course of oestrous cycle in sheep the concentrations of beta-endorphin (beta-END) in the infundibular and paraventricular nuclei as well as in the pituitary gland under physiological and stress conditions were determined, while in rats the metabolism of brain serotonin was investigated. Footshocking in rats induced significant decrease in 5-HT concentrations in the fronto-parietal brain cortex, hippocampus, striatum, medial basal hypothalamus and the preoptic-anterior hypothalamic area. These results allow to suggest that the decline in brain 5-HT under stress conditions has some associations with the impairments in the course of oestrous cycle. Measurements of the beta-END in perfusates of medial basal hypothalamus (nucl. infundibularis) in sheep evidenced significant increase of this opioid under stress conditions and it was postulated that this increase might be the main cause of the stress-induced impairments in the course of oestrous cycle and inhibition of LH-release. In addition, it was found that beta-END suppressed the secretion of cortisol and attenuated some noxious consequences of general nature for organism.

Animals↗

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Activity of noradrenergic neurons of medial-basal hypothalamus of female rabbits in some stages of reproduction.

Activity of noradrenergic neurons of medial-basal hypothalamus of female rabbits in some stages of reproduction. Acta Physiol. Pol., 1978, 29 (2): 111--115. The differences were found in the activity of noradrenergic neurons of medial-basal hypothalmus (MBH) estimated by the analysis of metabolism of intraventricularly infused 3H-noradrenaline (3H-NA) in various stages of reproduction in female rabbits. The gonadal hormones and especially 17beta-estradiol seem to be involved in this activity. The rapid disappearance of 3H-NA from MBH, found immediately after mating, implicates an involvement of noradrenaline in the process of Gn-RHs release form the rabbit hypothalamus.

Animals↗

PubMedDate not supplied

Noradrenaline turnover rate in the mediobasal and anterior hypothalamus of the rabbit.

Noradrenaline turnover rate in the mediobasal and anterior hypothalamus of the rabbit. Acta Physiol. Pol., 1977, 28 (1): 39-43. The rate of noradrenaline (NA) turnover in mediobasal hypothalamus (MBH) and anterior hypothalamus (AH) of the rabbit was estimated by steady-state isotopic method with a tritiated noradrenaline (3H-NA) as a tracer. The disappearance rate of 3H-NA both in MBH and in AH was found to be biphasic; the first rapid phase of the NA half-life of about 30 min, followed by the second phase of slower decay of the half-life of 2.4 h and 10 h for MBH and AH respectively. The results suggest an existence of more than one metabolic pool of endogenous noradrenaline in MBH and AH and indicate regional difference in the metabolism of NA stores in the hypothalamus.

Animals↗

PubMedDate not supplied

[Graphic method of determining laboratory criteria for iron deficiency].

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Adolescent↗

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[Factors related to changes in hemoglobin levels in women over 1-year period].

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Adolescent↗

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Serotonin content of the anterior and medial-basal hypothalamus in the female rats throughout the course of estrous cycle.

Serotonin content in the anterior hypothalamic area (AHA) and medial basal (MBH) hypothalamus has been estimated (by the spectrofluorometric method) throughout the course of estrous cycle in the female rats. Serotonin content has been found to decrease significantly on the day of early and late proestrous in AHA and MBH, respectively. The involvement of serotonin in the process of regulation of gonadotropin releasing hormone(s) release on the level of AHA and MBH is discussed.

Animals↗

PubMedDate not supplied

[Incidence of ischemic heart disease symptoms among residents of Plock and Kutno].

An incidence of IHD in Płock and Kutno inhabitants has been analysed. Five hundred eighty men and seven hundred forty nine women from Płock, and 475 men and 579 women from Kutno, aged 18-79 years, have been examined. Ischemic heart disease has been diagnosed with Rose's test and resting ECG evaluated according to Minnesota code. The symptoms of IHD have been found in 18.8% of men and 27.3% of women from Płock, and in 17.5% of men and 22.6% of women in Kutno. In Płock population the diagnosis has been based mainly on anamneses while in Kutno--on ECG findings. More frequent ischemic disorders in ECG recordings in Kutno population has been reflected in IHD indices registered in the available documentation, eg. morality, interventions of emergency service, hospitalizations, and active counselling.

Adult↗