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Biomedical subjects

A Onishi

Publications and source records attributed to A Onishi.

At least 55 records · Page 3Linked to original sources
PubMed1975

Acute ischemic transection of peripheral axons in angiopathic neuropathy. No demyelination of fasciculus gracilis or decreased number or size of cytons of spinal ganglion neurons.

Demyelination (loss of myelin profiles) of posterior columns of the spinal cord in patients with neuropathy coming to autopsy usually has been interpreted as secondary to distal degeneration of peripheral nerve fibers. Previous experiments to test whether these pathologic changes could result from transecting peripheral nerves produced conflicting results. In a patient with necrotizing angiopathy in whom extensive regions of fiber transection began proximally at midthigh level, the density and diameter distribution of myelinated fibers of the fasciculus gracilis and the number and size distribution of cytons of L3 and L5 spinal ganglia have been obtained and compared with normative measurements. No discernible alteration was found, suggesting that acute degeneration of peripheral nerve fibers is not associated with loss or decrease in size of cytons of spinal ganglia or with loss or decrease in size of myelinated fibers in the fasciculus gracilis.

Acute Disease↗
PubMed1973

Oculopharyngeal involvement in familial neurogenic muscular atrophy.

A Japanese family with progressive spinal muscular atrophy is presented. Seven members in two generations were affected and the mode of inheritance was probably an autosomal recessive trait. A characteristic feature of this family was the presence of oculopharyngeal involvement in some of the affected members, in addition to the variable distribution of muscular atrophy among each of the affected members, such as mainly proximal or distal atrophies in the limbs. In one case the oculopharyngeal weakness appeared without limb involvement. The changes in the extremities were thought to be of neurogenic origin, and so was the progressive external ophthalmoplegia seen characteristically in these cases, although the latter was similar to ocular myopathy.

Action Potentials↗