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Biomedical subjects

A Oliverio

Publications and source records attributed to A Oliverio.

At least 109 records · Page 6Linked to original sources
PubMed1975

A genetic analysis of morphine-induced running and analgesia in the mouse.

A genetic analysis of morphine-induced analgesia and activity was conducted in mice belonging to the strains BALB/cJ, C57BL/6J, DBA/2J and to their F1 and backcross progenies. The results support previous findings showing that a negative correlation is evident between these two behavioral measures and support that their mode of inheritance is characterized by dominance or partial dominance. The biometric analysis conducted on the parental, F1 hybrid and backcross populations indicates very clearly that the effects of morphine are genetically determined.

Analgesia↗
PubMed1975

Morphine-induced running analgesia in two strains of mice following septal lesions or modification of brain amines.

Groups of two inbred strains of mice (C 57 B1/6J and DBA/2J) with septal and control lesions were tested for morphine-induced analgesia and running activity (running fit). As previously observed the effects of morphine on the running fit and analgesia were strain-dependent and a negative strain correlation was evident between the two measures in C 57 and DBA operated control mice which are characterized by different brain levels and turnover of cholinergic and adrenergic mediators. Septal lesions, which cause a reduction in the levels of acetylcholine in the brain areas which receive a cholinergikc input from the septum, anatogonized morphine analgesia in both strains while the running fit syndrome was unaffected. Pharmacological manipulation of brain catecholamines did not interfer with morphine-induced analgesia. The effacts of different pharmacological agents with interfere with noradrenaline synthesis and catecholamine oxidation were assessed in the two strains which are characterized by presence (C 57) or absence (DBA) of increased motor activity following the injection of morphine. The results argue against an exclusive association of morphine-induced motor activity with noradrenergic mechanism.

Analgesia↗
PubMed1975

Dominance behavior: a phylogenetic analysis in the mouse.

Tube-dominance behavior differed significantly in C57BL/6By and BALB/cBy mice. Evaluation of these two inbred strains, and their recently developed recombinant inbred strains permitted the derivation of an hypothesis regarding possible genetic control of this behavior in mice. The results were analyzed by means of patristic matrices with accompanying phylogenetic tree analysis that marks the first occasion that such analysis has been used for a behavioral trait. Based on the data obtained and the statistical analyses and groupings of the various strains, the most satisfactory hypothesis that can be proposed at this time is one which assumes that dominance behavior, as measured in this experiment, is influenced genetically by at least 3 loci. Attempts to link these loci were not successful.

Aggression↗
PubMed1975

Effects of genetic and nutritional factors on post-natal reflex and behavioral development in the mouse.

The development of a number of reflex activities, of the electrocorticogram (ECoG), and measures of brain and body weight were assessed at different ages from birth to maturity in mice belonging to Swiss-Webster stock and two inbred strains (C57BL/6J and SEC/1Re). The animals also were tested at 60 days of age for exploratory activity and avoidance behavior. These effects of postnatal undernutrition on the measures of reflex and ECoG activity, brain and body weight and avoidance learning were determined at different ages after birth and in adult animals following dietary rehabilitation. Undernutrition during suckling period was introduced by increasing the litter size from 4 pups to 8 or 16 pups per litter. The results indicate that early malnutrition delayed the development of the reflex and ECoG activities and permanently altered brain growth and avoidance learning. The effects were different, depending on the genotype considered. The data indicate that strains characterized by a slower development of brain function do not show early signs of brain malfunction following undernutrition.

Age Factors↗