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Biomedical subjects

A Oliverio

Publications and source records attributed to A Oliverio.

At least 91 records · Page 5Linked to original sources
PubMed1981

Development of morphine-induced changes of activity in the mouse.

The development of spontaneous activity in response to morphine administration was studied at different postnatal ages in C57BL/6 mice. Morphine induced hyperactivity at all ages except in 3-week-old mice, in which a catatonic effect is evident. The results indicate that the neurophysiological and inhibitory systems responsible for the non-analgesic effects of morphine are not characterized by the same developmental pattern.

Aging↗
PubMed1981

Effects of isolation on activity, reactivity, excitability and aggressive behavior in two inbred strains of mice.

In order to investigate mechanisms of isolation-induced aggressive behaviour, inbred mice of the C57BL/6 and DBA/2 strains were individually housed over a period of 8 weeks. In the DBA/2 strain only, isolation was followed by a clear increase in activity (Animex), reactivity (reactions upon tactile body stimulation), excitability (duration of EEG desynchronization elicited by tactile stimulation of the thorax area under urethane anesthesia) and intermale aggression (biting and fighting responses). The use of inbred strains of mice proved to be a useful tool for the examination of the relationship between various parameters. It is concluded that there are no clear correlations between activity, reactivity and aggressive behavior and that the resulting aggressive responses in the DBA/2 strain are likely due to the increase of excitability.

Aggression↗
PubMed1980

Effects of chlordiazepoxide-morphine combinations on spontaneous locomotor activity in three inbred strains of mice.

Spontaneous locomotor activity has been studied, in three strains of mice, following the administration of morphine and chlordiazepoxide, given alone or in combination. The results demonstrate that chlordiazepoxide enhances the morphine-induced locomotor stimulation in C57/BL/6 and BALB/c mice and counteracts the depressant effect exerted by morphine in DBA/2 mice.

Animals↗
PubMed1979

Wheel running sleep in two strains of mice: plasticity and rigidity in the expression of circadian rhythmicity.

The effects of 12--12 h, 6--6 h, 3--3 h and 1--1 h light--dark (L-D) cycles and of constant light (L--L) on wheel-running activity and electrograhically defined sleep were studied in two strains of mice, C57BL/6 and SEC/1Re. Wheel-running activity was inhibited by light and enhanced by darkness; however, in the C57 strain the L-D-induced changes were less pronounced and superimposed to a clear circadian rhythm. Under the L-L schedule clear patterns of daily rhythmicity were evident in the C57 strain but not in the SEC strain. Sleep was enhanced by light and inhibited by darkness. The L-D-induced changes of sleep were superimposed on the circadian rhythm in both strains; however, in the C57 strain these changes were larger in the circadian phase in which the animals were active. Under the L-L-schedule the C57 strain was characterized by more clear-cut patterns of daily rhythmicity than SEC mice. These phenomena are discussed in terms of plasticity of free-running rhythms of sleep and activity and of the genetic factors involved in the expression of circadian rhythmicity.

Animals↗
PubMed1979

Effects of apomorphine and sodium Di-n-propylacetate on the aggressive behaviour of three strains of mice.

1. The effects of apomorphine and sodium Di-n-propylacetate (DPA, sodium valproate) on pain-induced aggressive behavior were investigated in three inbred strains of mice: BALB/c, C57B1/6 and DBA/2, which exhibited spontaneously low levels of aggression. 2. Apomorphine elicited aggressive behavior in the three strains, the range of effective doses being different for each strain of mice. 3. Di-n-propylacetate was effective in inhibiting apomorphine elicited aggression but the three strains exhibited a different sensitivity to this drug. 4. The effects of Di-n-propylacetate were not related to pain sensitivity, posture and locomotion. Only C57 strain exhibited a slight postural and locomotor impairment when injected with a higher dose of Di-n-propylacetate. 5. The results are discussed in terms of a genetic inference and of biological differences existing between these three strains.

Aggression↗
PubMed1979

Ontogeny of behavioral development, arousal and stereotypes in two strains of mice.

A number of reflexes and amphetamine-induced locomotor and stereotyped behavior were assesses in 8, 16, 32, 90 and 360 day old C57BL/6J and SEC/1ReJ inbred mice. The data indicate that C57 mice are more precocious for a number of neuronal and behavioral mechanisms while SEC mice are less mature at birth. In addition, there are appreciable fluctuations of these behavioral patterns throughout life. A rise in arousal levels was evident in both strains between 8 and 16 days and between 32 and 90 days of age. Three-hundred-sixty days old mice presented a general decrease in the levels of arousal. These findings are discussed in terms of neuronal and behavioral plasticity and in relation to the ontogeny of the different catecholaminergic systems which modulate excitory and inhibitory different behavioral patterns at different ages.

Aging↗
PubMed1978

Effect of clonidine, amphetamine, and their combinations on the locomotor activity of CD-1 and C57BL/6 mice.

Clonidine inhibited the exploratory motor activity of C57BL/6 mice non-habituated to the testing conditions. In CD-1 mice clonidine did not depress exploratory activity but did elevate the basal locomotor activity of animals both non-habituated and habituated to testing conditions. Amphetamine increased the locomotor activity of many C57BL/6 mice and conversely inhibited the locomotion of many CD-1 mice. In both strains, amphetamine in doses up to 2 mg/kg was unable to alter effects produced by clonidine. Results suggest that the locomotor activity of C57BL/6 mice is more sensitive than that of CD-1 mice to drugs affecting the central noradrenergic system.

Amphetamine↗
PubMed1976

Effects of heroin, alone or in combination with other drugs, on the locomotor activity in two inbred strains of mice.

The locomotor activity of C57Bl/6J and DBA/2J mice was studied, under the influences of heroin, amphetamine, strychnine, or ethanol, and of combinations of the opiate with each one of the other drugs. Heroin treatment was followed by the typical "running fit" in the C57 mice, while the DBA strain was unaffected. Amphetamine enhanced the activity in the C57 strain only. The combination of heroin with amphetamine or ethanol increased the locomotor activity only in the DBA strain, while heroin + strychnine exerted a clear stimulating effect on the activity of the C57 mice. The strychnine + heroin mixture was more toxic than heroin alone when the lethal doses (LD50) were determined in the 2 strains.

Amphetamine↗
PubMed1976

Early malnutrition and postnatal changes in brain and behavior in the mouse.

The effects of early undernutrition were studied by rearing mice in small, intermediate or large litters (respectively 4, 8 or 16 pups). Measures of reflexes and electrocorticographic activity applied from birth to weaning indicated that malnutrition resulted in a clear ontogenetic retardation which was followed by permanent body and brain stunting. The mice from the large litters were characterized by increased exploratory activity and by lower avoidance learning ability as measured 45 days after nutritional rehabilitation.

Animals↗
PubMed1975

[Genetic analysis of circadian activity rhythm in mice].

Mice of the inbred strains C57BL/6J and SEC/1 ReJ show high patterns of wheel running activity during the night when placed in a condition of 12h of darkness and 12h of light. Under continuous illumination or darkness the C57 strain is characterized by a clearcut circadian rhythm while the patterns of activity of the SEC strain do not show a clear thythmic activity.

Activity Cycles↗
PubMed1975

Morphine sensitivity and tolerance: a genetic investigation in the mouse.

Sensitivity and tolerance to morphine were determined in 2 strains of mice, BALB/cBy and C57BL/6By, their reciprocal F1 hybrids and seven of their recombinant inbred strains. Sensitivity was established based on locomotor activity following the administration of saline, 10 or 20 mg/kg of morphine hydrochloride while tolerance was established according to the "hot plate" method following the single or repeated administration of saline, 5, 10, or 20 mg/kg of morphine hydrochloride. Results indicate that both sensitivity and tolerance to morphine are genotype-dependent and their inheritance is characterized by dominance or partical dominance. Further clarification of the genetic relationship of sensitivity, tolerance and analgesia to morphine must await analysis of the brain morphine-binding protein currently being conducted.

Analgesia↗