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Biomedical subjects

A Nowakowski

Publications and source records attributed to A Nowakowski.

63 records · Page 4Linked to original sources
PubMedDate not supplied

Erythromelalgia--a thrombotic complication in chronic myeloproliferative disorders.

Erythromelalgia is a very specific, thrombotic syndrome related with thrombocythemia that may occur during the course of chronic myeloproliferative disorders (MPD), especially polycythemia vera (PV) and essential thrombocythemia (ET). This poorly understood clinical syndrome is characterized by red, congested distal extremities and painful burning sensations, usually confined to the ball of the foot and one or more toes or fingers. If left untreated, it may progress towards acrocyanosis and even peripheral gangrene. Sometimes, it may precede the diagnosis of MPD by months or years. The pathophysiological aspects of erythromelalgia as well as its differentiation with erythermalgia have been reviewed in this study.

Chronic Disease↗
PubMedDate not supplied

[Value of determination of mononuclear blood cell proliferation in vitro in the diagnosis of lymphosarcoma].

The authors describe mitotic activity in non-stimulated cultures of mononuclear cells obtained from the peripheral blood of patients with lymphosarcoma. The investigations were carried out on 3 patients in stage 3rd and 4th of this disease and 5 patients in the stage of sarcomatous-cell leukaemia. During a period of 24-48 hours after setting up of culture a rise was observed in the number of blast cells and appearance of up to 10% of mitotic figures. This observation may be useful for differentiation of sarcomatous-cell leukaemia from chronic lymphocytic leukaemia in which cells obtained from the peripheral blood and cultured in vitro without addition of mitogen do not demonstrate mitotic activity.

Adolescent↗
PubMedDate not supplied

[Ultrastructure and cytochemistry of neutrophil granulocyte series in the bone marrow of white rats].

Ultrastructure of the neutrophil granulocyte series of rat was studied. Besides morphological investigations of maturating cells activity changes of two selected enzymes were determined: acid phosphatase and peroxidase. It was observed that the activity of acid phosphatase is connected with appearance of primary granules and peroxidase activity is connected with these granules as well but shows different location at different developmental levels of these cells.

Acid Phosphatase↗
PubMedDate not supplied

[Effect of vitamin E on the function of blood platelets in patients with diabetes mellitus].

An effect of vitamin E on blood platelets functioning was studied in 39 patients with diabetes mellitus type 1. Control group included 20 healthy blood donors. Vitamin E in a daily dose of 1000 mg produced statistically significant decrease in platelets aggregation, number of circulating platelet aggregates and release of the platelet factory 4 in diabetics after 7 days of treatment. No adverse reactions were seen in any patient treated with vitamin E. The obtained results indicate that vitamin E inhibits increased platelets activity in the patients with diabetes mellitus type 1 and does not exert toxic reactions during the treatment.

Adult↗
PubMedDate not supplied

[Hairy cell leukemia in the light of an observed case].

A case of hairy-cell leukaemia was observed in a man aged 40 years. The diagnosis was based on the whole of clinical investigations and laboratory investigations, especially cytoenzymatic examination of leukaemic cells and examination of their structure in electron microscope. In treatment radiotherapy was appleid initially followed by splenectomy.

Acid Phosphatase↗
PubMedDate not supplied

[Cytochemical studies of primary granules in rat neutrophils: an electron microscope study].

Cytochemical investigations were carried out on primary granules in neutrophils in rats. For this purpose reaction for acid phosphatase and then using the same preparations of bone marrow peroxidase activity was determined. Peroxidase activity was demonstrated in all granules of first order (primary), but only in a part of them the activity of acid phosphatase was present. These granules are, most probably, lysosomes containing peroxidases apart from hydrolases.

Acid Phosphatase↗