Search PubMed⌕ Search

Biomedical subjects

A Nowak

Publications and source records attributed to A Nowak.

At least 145 records · Page 8Linked to original sources
PubMed1985

Indoor air pollution due to tobacco smoke under real conditions. Preliminary results.

A short review exploring the generation and composition of tobacco smoke is given. Experimental arrangements used to record sidestream smoke are critically discussed. Data from own experiments in a tobacco smoke polluted office room were presented and discussed. These data include nicotine, ammonia, formaldehyde, acetaldehyde, hydrogen cyanide, CO, NO and NO2. First results about the diameter of the particles in the smoke polluted room were also given. By the aid of the RINGOLD's equation the COHB content on basis of the CO-values of exhaled breath of active and passive smokers were determined. Data about the nitrosamine content in the air of the room during the smoke tests were also given and discussed.

Carbon Monoxide↗
PubMed1984

Controlled therapeutic trial of levamisole and sulphasalazine in acute ulcerative colitis.

Forty five patients with acute ulcerative colitis were randomly allocated to receive (a) sulphasalazine, (b) levamisole, or (c) a combination of sulphasalazine and levamisole. Each group contained 15 patients. The ulcerative colitis activity index (UCAI), the remission and relapse rates were compared at three monthly intervals for one year. The UCAI fell in each group. Detailed analysis of all clinical and biochemical parameters used for estimation of UCAI showed that the only difference was in patients receiving combined therapy who continued to have a raised ESR and platelet count. Fewer patients, however, went into remission on levamisole therapy (46.6%) compared with the other two groups (66.6%). The cumulative relapse rate was 20% for those receiving levamisole compared with 6.6% in the other groups. Side effects were observed in 20% of patients receiving levamisole, 26% receiving sulphasalazine, and 40% in those having combined therapy. The results indicate that levamisole is unlikely to have a major role in the management of patients with ulcerative colitis.

Acute Disease↗
PubMed1984

Ranitidine in the maintenance therapy of gastro-duodenal ulcer disease: Polish open multicentre study.

Our first stage 3-week trial (6) and second stage up to 6 weeks (7) showed that ranitidine provides the highest healing rate of 97% for duodenal and 95% for gastric ulcer. The study has been now prolonged for one year to assess the efficacy of maintenance therapy. Out of 258 patients who completed the second stage 232 voluntarily entered the open stage 3 in which they were given a single dose R 150 mg nocte, and were endoscopied after 4, 8 and 12 months. There were 153 duodenal and 79 gastric ulcers. 191 patients completed the study; no undesired effects were found and there was no medical reason to withdraw the drug from the long term use. Recurrent ulcer was found in 33.3% out of 126 duodenal ulcer cases, and in 29.2% out of 65 gastric ulcer patients who completed stage three. Sixteen percent of recurrent gastric ulcers and 26% of duodenal ulcers were asymptomatic. Recurrence rate was about twice as high in smokers as in non-smokers. These findings were compared with our long-term endoscopic survey of the natural history of peptic ulcer disease (8) in which yearly recurrence rate of duodenal ulcer was 68.4% and of gastric ulcers 73.5%, 14% of them being painless. This indicates that R is fairly well tolerated in long term use and may be useful to curb the ulcer recurrence rate.

Adult↗
PubMed1983

Penetration of trimethoprim and sulfamethoxazole into skin blister fluid.

In 32 patients the concentrations of sulfamethoxazole and trimethoprim in whole blood, plasma and skin blister fluid were studied in the course of treatment with co-trimoxazole and trimethoprim alone. Measurements were taken on the fourth day of treatment, 3 h after administration of the morning dose of the drug. The blood contained a lower concentration of sulfamethoxazole than plasma. About 70% of the sulfonamide penetrated into the exudate from plasma. Trimethoprim administered conjointly with sulfamethoxazole to a higher degree penetrated skin blister fluid to a greater extent than when given alone.

Adolescent↗