[Ligneous conjunctivitis: a disease of unknown etiology].
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Biomedical subjects
Publications and source records attributed to A Nover.
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The development of changes in the iris, with unexpected histologic diagnoses, is described. One patient was found to be suffering from bilateral iris nodules, the unexpected manifestation of a Boeck's sarcoid which had not been diagnosed. In another case, the growth observed in the size of the tumor seemed to indicate malignancy, although histology showed it to be a benign leiomyoma with increasingly cystic changes. In the third case we suspected a metastasis of a bronchial carcinoma but histologic examination showed it to be a malignant melanoma. The various differential diagnostic considerations are discussed.
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The authors examined four cases of keratoglobus and report here on the histological changes found: degenerative alterations of the epithelium, characteristic changes of Bowman's membrane, such as thinning, detachment and wrinkling, alterations of the stroma and secondary alterations of the Descemet's membrane. These results indicate that keratoglobus is nearly an extreme variant of keratoconus.
Nine years after enucleation of the right eye because of a choroidal melanoma a choroidal melanoma a metastasis of the melanoma developed in the left orbit. Histologically, the two tumors were identical spindle-cell B melanomas. No other primary tumors or metastases were found. This is only the third case of this rare form of metastasization ever reported.
Functional and morphological side effects of oral contraceptives on the eye are demonstrated by own findings and by literature. Possible aetiopathogenetic interrelations and the significance of an intensive ophthalmological examination of all patients who complain about decreasing vision under hormonal contraception are pointed out.
Two personal observations on malignant non-Hodgkin lymphomas of the eye are presented, i.e., a lymphoplasmocytoid lymphoma (so-called immunocytoma) of the lid and orbita and a case of mixed centroblastic-centrocytic lymphoma of the lacrymal sac. The different histological findings are demonstrated. According to the lymphoma-classification by Lennert (Kiel), both the tumours belong to the group with a low degree of malignancy. No general synptoms could be found in the afflicted patients.
After the description of the most important differential diagnoses of leukocoria in childhood, their ultrasonographical findings in both A- and B-mode are discussed. Ultrasound proofs to be a useful aid in the evaluation of leukocoria.
Report on local application of Cystin eye drops in a case of scleromalacia perforans. This medication brought the necrotizing disease process to a standstill. There was even discrete neoformation of scleral tissue, which we attribute to the collagenase inhibiting action of this drug.
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At the University eye clinic in Mainz a new method was carried out on 40 patients to coagulate the ciliary body whereby this was laid open and directly coagulated. In the post operative stage within the first 4 weeks a further increase of pressure could be observed in 3 cases only. The other patients, who have been observed up to 15 months, did not show any further increase of pressure and are well. This operation method is commendable especially in the cases of hemorhagic and absolute glaucoma.
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After a short description of the general symptoms of Down's syndrome, the ophthalmologic aspects of the disease are discussed. The study is based on the examination of 1047 mongolian children. The various eye-symptoms were present in different frequencies according to sex and type. The results were compared with those in the literature of the last 100 years and identical as well as highly significant divergent values were found.
The standard investigations in neuroophthalmological diagnosis (inspection of the eye for accomodation, determination of visual acuity, perimetry, ophthalmoscopy) are compared with special methods of investigation. Echography and computer tomography in orbital diseases and fluorescence angiography as a differential diagnostic aid in pathological findings in the papilla are dealt with in detail.
Computed tomography (CT) has given us a new method for examining the orbit and its contents. The technique of examination is described, and the indications for the application of computed tomography in ophthalmology are considered: suspected orbital tumors, unilateral exophthalmos, pareses of the ocular muscles, traumatic lesions and malformations in the region of the orbit. The findings in 210 cases of orbital lesions examined in this study are reported and the differential diagnosis is discussed. Considerable improvement and greater accuracy in diagnosis have been achieved in the field of ophthalmology by using computed tomography. Early tumor visualization is possible without risk or discomfort to the patient.
From 1963 to 1973 379 eyes were removed surgically. This represents a constant ratio during this eleven year-period of 2.1% of the in-patients and 2.3% of the patients treated surgically. Mostly elderly patients were affected, men more often than women. The ultimate reason for enucleation was uncontrollable pain in most of the cases. The most frequent cause for the loss of the eye were penetrating injuries (31.1%) and intraocular tumors (30.6%). Histology was done in 83.6% of the cases. Amongst 116 eyes enucleated for intraocular tumors or suspicion of tumor-growth no tumor was seen microscopically in seven cases. In 7 out of 118 eyes (5.1%) encleated for glaucoma absolutum a malignant tumor was found.