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Biomedical subjects

A Nikolov

Publications and source records attributed to A Nikolov.

At least 109 records · Page 6Linked to original sources
PubMed1996

[The efficacy and safety of nafarelin in treating genital endometriosis].

A prospective study was carried out a State Institute Hospital "Maĭchin dom" aiming to estimate the efficacy of GnRH-agonist Nafarelin in treating patients with endometriosis. Nafarelin was used by 40 women with endometriosis. The drug was applied as a nasal spray according to a therapeutic scheme and regarding definite criteria. Every patient was followed while using the drug and the following sings were registered: occurrence of amenorrhea, clinical sings, side effects, the period of control lasting for a year after the end of the treatment. In 27 women a quick and long-lasting amenorrhoea was induced with standard doses of the drug, while other 13 needed higher dosage to achieve the same effect. Relief of complaints was registered on 35 women. Improved palpatory status was found in 23 patients. In 4 women the disappearance of endometriomas was confirmed by laparoscopy. The existing side-effects are dos to the appearing hypoestrogenemia. After treatment with Nafarelin, during the period of observation, 5 women got pregnant.

Administration, Intranasal↗
PubMed1996

[The effect of fetal maturity and the delivery method on fetal status in breech presentation].

In a retrospective study of 363 pregnancies with one foetus in breech presentation is evaluated the effect of foetal maturity and the route of delivery on the state of the newborn, assessed by the 5 min. Apgar score. The cases are allocated in subgroups according the foetal weight and height, gestational week and the route of delivery. The results show 37% small for gestational age in the subgroup with low birth weight (1500-2500 g). From the group with low weight SGA sustain better the labor and delivery than the eutrophic. The term newborn in breech presentation are with higher Apgar score than delivered by cesarean section. In the group of newborn with low weight the route of delivery has not effect on the Apgar score. The estimated weight and gestational week should be taken in account than managing breech labor.

Adult↗
PubMed1996

[The side effects of the prevention of blood loss in the placental period].

On the base of 192 retrospective and 144 prospective cases are evaluated the side of routine prophylactic of the blood loss at the third period of labor. The control group consist of 50 labouring women with expective management of placental period. In normotensive women the methergine does not increase the blood pressure. The use of oxytocic drugs after the delivery of the head shorten the time of placental separation but make more difficult the cord traction method for the delivery of the placenta. The active management of the placental period decrease the rate of instrumental revision of the uterine cavity and the supplemental administration of oxytocic in the early postpartum period. This investigation confirms and justify the routine use of oxytocic after the delivery of the head as a prophylactic of the blood loss in the placental period.

Analysis of Variance↗
PubMed1996

[Blood loss in the placental period in relation to the type of prophylaxis].

The aim of this study is to asses the blood loss in third period of labor according the method of its prophylactic. The material consist of 144 prospective and 192 retrospective cases. The blood loss is assessed visually and after that it is weighted. Up to the delivery of placenta the visually assessed blood loss is insignificantly greater than the weighted one. All cases are subdivided in three groups according the management of third period: -with methergin, with oxytocin and without uterostonic. The blood loss associated with the separation and delivery of the placenta is not different in the groups, but the early postpartum haemorrhage is significantly greater in the cases without uterostonics for the delivery of placenta. In premature labors the blood loss associated with the separation of placenta is significantly greater that in term labor.

Analysis of Variance↗
PubMed1995

Influence of arginine-8-vasotocin and indomethacin on in vitro progesterone secretion by porcine granulosa cells.

The effect of the nonapeptide hormone arginine-8-vasotocin (AVT) and indomethacin on progesterone (P) production by cultured granulosa cells (GCs) from porcine preovulatory follicles was investigated. AVT dose-dependently stimulated the release of P by GCs. Basal and AVT-stimulated P secretion was inhibited when cultures were pretreated with the cyclooxigenase inhibitor indomethacin. These results suggest that AVT is involved in the local control of porcine follicle functions and that the effects of AVT on the P release are dependent on the endogenous production of prostaglandins (PGs) in the GCs.

Journal Article↗
PubMed1995

[The place of vacuum extraction in modern obstetrics].

A clinical trial was carried out on the use of vacuum extraction for delivery of 45 women. The aim of the study is to revive again this method for it was rarely used during the last years. The authors remind of the indications and necessary condition for the use of vacuum extraction and report about complications and the course of the placental period. Parallel to this, the 45 babies born with vacuum, are followed up according birth weight, gestational age, clinical status and laboratory data by birth, resuscitation after delivery and birth trauma. By summing up the results the authors divide women (and babies) in 3 groups: deliveries with vacuum extraction (VE), VE+ forceps, Vstimmulation and forceps, Conclusions are made that VE is a useful method nowadays if classical conditions and indications are followed. The babies born by VE are in good status without serious traumas. Vstimmulation + forceps is rejected as more harmful method.

Adult↗
PubMed1995

[Herpes simplex infection in newborn infants].

Six cases of proven herpes simplex infection in newborn babies are reported. Different clinical forms are observed: three babies with multisystem disease that attacked viscera and other three with central nervous system localisation. All six mothers have negative history for being carrier of herpes simplex virus. The babies are treated with Herpesbulin, Pandavir and Zovirax. One of them died with meningoencephalitis. The outcome at the age of three months after birth of the other 5 babies is: 2 babies are healthy, three developed late sequelae.

Acyclovir↗
PubMed1993

[Our clinical experience in treating endometriosis genitalis externa with the preparation Danoval].

By means of the serum level of estradiol and the vaginal smear indexes the antigonadotropic activity of the preparation Danoval (2-3-isoxasol-17-ethinyltestosterone) is indirectly evaluated on 15 infertility patients with laparoscopic proved endometriosis. After 5 month's course of treatment with 400 mg daily the level of estradiol decreased from 1.54 to 0.31 nmol/l, IA from 20.8 to 10.4 and IP from 32 to 17.3. The side effects are slight and descend from the pharmacological properties of the preparation. Two patients became pregnant in three months after the treatment.

Adnexal Diseases↗
PubMed1991

[The assessment of the clinical and microbiological status of the lower genital tract in women with sterility].

The study was carried out on 40 randomly selected patients with sterility, in whom microbiological examination of the lower genital tract was performed. Pathogenic microorganisms were isolated in the vaginal secretion of 10 out of 26 patients with primary sterility, but in the cervical secretion in 8 out of 26 women. Similar finding was found in 5 patients out of 14 patients with secondary sterility. The obtained results were compared with the complaints of women and their gynecological examination. Attention is paid again to the necessity of complex evaluation on the character of microbiological flora in view of the frequent usage of invasive methods in diagnosis and treatment of sterility.

Adult↗
PubMed1991

[A method for the repair of the cervix uteri in conization].

The technique for repair of the uterine cervix after circumferential cut and conization is described. The sewing is made by placing two symmetrical sutures, by which invagination is achieved simultaneously at sagittal and lateral sides. The authors have used the method in 400 patients for a period of 12 years as its good hemostatic and plastic effect is established. Attention is also paid to the observation on 18 women, who have became pregnant and delivered after conization and repair of the uterine cervix by the described method--11 out of 18 women have been delivered of infants through natural birth pathways.

Cervix Uteri↗
PubMed1991

[Folliculometry as a method for determining ovulation in insemination with frozen sperm].

The authors carried out studies retrospectively on 57 women, who became pregnant in insemination with donor frozen spermatozoa. Ovulation problems and luteal insufficiency were diagnosed in advance and treated before and during the occurring cycles. Women were divided into two groups. The first group of 25 women were examined by ultrasound transvaginal transducer for follow-up of follicle growth in the ovaries in addition to measurement of body temperature and determination of the cervical factor. The second group of 32 women, in whom follicle-metry was not performed. The frequency of conception was 0.24 in the first group, but 0.26 in the second group. It is concluded that inspite of the significance of follicle-metry for determination of ovulation the traditional methods are still valid criteria for ovulation and can be used as independent methods for determination of the time for insemination with therapeutic donor frozen spermatozoa.

Female↗