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Biomedical subjects

A Netter

Publications and source records attributed to A Netter.

At least 37 records · Page 2Linked to original sources
PubMed1975

[Estroprogestational drugs and the ultimate embyogenesis in the rat].

Cyclic female rats were fed with ethinodiol diacetate plus mestranol (EDM) for periods of 45 to 180 days. They were mated during prooestrus, on the first cycle following the end of the treatment. Results were as follows: 1. The cycle is blocked about eight days after starting E.D.M. The longer the treatment, the later rats resume their cycle. 2. Degeneration of the ova before implantation and embryonic mortality are slightly augmented when fecundation takes place within two days after stopping E.D.M.; whereas from the third cycle on, the quality of th ova is identical to the control group. The ova are euploid; they are more fragile to hypotonic shock than the ova of the control animals. No influence of E.D.M. upon meiotic or mitotic processes could be demonstrated. Those experiments do no allow any inference to the human species, but they are inkeeping with the observations of Boué et al. on women.

Animals↗
PubMed1975

[Ovarian hyperstimulation syndrome. Notes on the physiopathology and treatment apropos of 3 cases].

Hyperstimulation appeared in one case on the 10th 11th day after ovulation, allowing by its presence the very precocious diagnosis of successful fecondation. The study of blood coagulation revealed that hypercoagulability was mainly related to hyperactivity of the thrombocytes and of the coagulation proteins. The pathogenesis of the syndrome is discussed. Increase in the permeability of the capillary vessels and hypovolemia seem to be responsible for the main accidents. Unfortunately as we have no real mean of decreasing the permeability of the capillary vessels, the treatment can be directed only against hypovolemia and its results. The infusion of macromolecular fluids, the restriction of sodium and water intake, together with the prescription of spironolactone have been successfully employed in those three cases.

Adult↗