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Biomedical subjects

A Netter

Publications and source records attributed to A Netter.

At least 19 recordsLinked to original sources
PubMed1991

HLA antigen-sharing in couples with repeated spontaneous abortions and the birthweight of babies in successful pregnancies.

Previously, several groups reported an increase in HLA antigen-sharing in couples suffering from unexplained repeated spontaneous abortions. It was felt necessary to find out if HLA sharing could have any effect on children born after a successful pregnancy. The birthweight figures of children of 76 couples with repeated spontaneous abortions were analyzed. The results show a significantly lower birthweight in babies born from those couples, presenting a high incidence of HLA antigen-sharing, particularly concerning class II antigens.

Abortion, Habitual↗
PubMed1990

Effect of Decapeptyl, an agonistic analog of gonadotropin-releasing hormone on estrogens, estrogen sulfates, and progesterone receptors in leiomyoma and myometrium.

Estrogens (estrone [E1] and estradiol [E2]), their sulfates and progesterone receptor (PR) were evaluated in patients with uterine leiomyomata nontreated and treated with Decapeptyl (D-Trp6-gonadotropin-releasing hormone [GnRH]; Ipsen Biotech, Paris, France). Estrogen concentrations are very high in the leiomyoma (secretory phase, pg/g tissue [mean +/- SEM]: n = 10; E1: 147 +/- 24; E2: 850 +/- 116; E1-sulfate: 1,668 +/- 808; E2-sulfate: 718 +/- 126). Decapeptyl treatment provokes a significant decrease in E2 and particularly in E1 and E2 sulfates. Progesterone receptors were higher in the leiomyoma than in the myometrium; after a long treatment (3 to 4 months) a significant decrease in both tissues is observed. The decrease provoked by D-Trp6-GnRH on estrogens (unconjugated and sulfates) and in PR in the leiomyoma after long treatment, supports the hypothesis that estrogens are implicated in the cause of these tumors.

Adult↗
PubMed1990

[Effect of decapeptyl (D-TrpG GnPh) on estrogen receptors, progesterone receptors and tissue levels of estrogens (non-conjugated and sulfate-conjugated) in patients with uterine myoma].

Concentrations of estrogen receptors, progesterone receptors, unconjugated estrogens (estradiol and estrone) and sulfate-conjugated estrogens (estradiol sulfate and estrone sulfate) were determined in patients treated with Decapeptyl and in controls. After prolonged Decapeptyl therapy, a highly significant fall in progesterone receptors was evidenced; estrogen receptors were found to be decreased in the myoma as compared with the secretory phase in controls and in the myometrium as compared with the proliferative phase in controls. Tissue levels of estrone sulfate and estradiol sulfate decreased very substantially. In conclusion, Decapeptyl emerges as a very promising agent for the treatment of uterine myomas.

Antineoplastic Agents↗
PubMed1987

Methodical intrauterine resection.

A technique using a fine intrauterine resectoscope with mobile electrical loop and continuous flow providing a thoroughly clear vision in all circumstances was used to resect 61 submucous leiomyomas. This technique allows complete resection of intrauterine benign tumours such as submucous leiomyoma sessile type partially embedded in the myometrium, old and wide marginal synechiae, or uterine septa. Under direct visual control it allows one to perform deep biopsies leading to precise histologic diagnoses with determination of possible myometrial penetration. The advantages of this technique, which may be performed eventually on outpatients with paracervical block, are: precise hemostasis; complete and controlled uterine evacuation, avoiding postoperative infections; precise histologic diagnosis; suppression of a good percentage of hysterectomies and open myomectomies; simplicity of follow-up; brevity of hospitalization and convalescence, which are sometimes nil; and conservation, or even restoration, of fertility.

Adult↗