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Biomedical subjects

A Nemes

Publications and source records attributed to A Nemes.

At least 55 records · Page 3Linked to original sources
PubMed1985

Application of a vascular graft material (Solcograft-P) in experimental surgery.

The implantation and post-implantation behaviour of a Solcograft-P vascular prosthesis in the aortic, aorto-iliac, carotid and vena caval positions in dogs was studied up to 100 d post-surgery in order to assess the suitability of this vascular material for use in man. Solcograft-P is prepared from the carotid arteries of calves by crosslinking the collagen stroma using adipyl dichloride. During the postoperative follow-up period of 3 month, 100% of the aortal grafts, 80% of the aorto-iliac bypasses, 60% of the vena caval grafts and 35% of the carotid implants remained patent. The biochemical properties of the Solcograft-P are better than those of Solcograft, its predecessor. The intimal lining was consistently smooth and homogeneous in grafts of biological origin, and no aneurysm was observed. Infection and early thrombosis occured no more frequently than with other grafts. The new Solcograft-P, crosslinked via ester and amide groups, seems to represent a real improvement over Solcograft. Our results suggest that Solcograft-P should prove valuable in various cases of reconstructive vascular surgery of the lower limb, especially when the autologous vena saphena magna is not available, and its mechanical properties may well prove suitable for both arterial and venous replacement.

Animals↗
PubMed1982

Morphological experiences with a new bovine carotis xenograft (Solcograft-P) in experimental vascular surgery.

The implantation process of the Solcograft-P vascular prosthesis in infrarenal aortic and vena cava inferior positions was studied in dogs in the first 100 postoperative days to investigate its applicability in vascular surgery. The intimal lining was consistently smooth and homogeneous, the problems of aneurysma formation was not serious. Infection and early thrombosis were not more frequent than with other grafts. The impregnated Solcograft-P seemed to be superior to its previous version, the Solcograft. The morphological properties of Solcograft-P seem to make it suitable for venous replacement. The experiments suggested that in selected cases of reconstructive vascular surgery and particularly for patch plastics, Solcograft-P may prove useful.

Animals↗
PubMed1979

Surgical experience with simultaneous bilateral carotid endarterectomies.

Eighty patients who had undergone bilateral carotid endarterectomy at the same operation were reviewed. All operative procedures were performed under general anaesthesia and during systemic heparinization and in all but six cases by using internal shunt. There were three deaths related to the operation representing 3.8% hospital mortality. Transient neurological deficits were noted in four patients (5% incidence) and permanent neurological deficits in four patients (also 5% incidence). A 100% late follow-up after an average period of 48 months revealed that 85.7% of the long-term survivors were functionally normal or improved. There were ten late deaths with heart disease accounting for 50% and stroke 30%.

Aged↗
PubMed1979

Application of Solcograft in vascular surgery.

Incorporation of Solcograft was studied experimentally and clinically. The graft was found to facilitate the formation of continuous endothelium which starts at the vessel graft boundary and from newly formed capillaries. Transmission and scanning microscopical investigations revealed neointima, neomedia and neoadventitia formation in 3--4 months. Complications such as obliteration were unfrequent. Aneurysm formation did not occur, the potency rate was satisfacory. Experience in 20 clinical cases are reported in detail. As to its usefulness in reconstructive vascular surgery, Solcograft is placed behind the saphenous graft. The graft is particularly suitable for patch plastics.

Animals↗
PubMed1979

The effects of a deproteinized blood extract on the myocardial changes developing during experimentally induced intermittent hypoxia.

Myocardial hypoxia induced by intermittent cross-clamping of the aorto-coronary bypass during closed-heart surgery provokes progressive derangement of the myocardial metabolism. The principal changes observed after 18 min of hypoxia (without protection) were a marked swelling of mitochondria, distortion of cristae, reduction in glycogen content, interstitial oedema, focal destruction of I-band material and coagulation necrosis of myofilaments. Another characteristic change is the decoupling of oxidative phosphorylation. These morphological and biochemical changes were successfully prevented by the administration of Solcoseryl (Actihaemyl), a dialysis concentrate from deproteinised calf blood. The less pronounced structural and functional mitochondrial changes in protected hearts suggest that the myocardium is able to tolerate a more severe hypoxia under Solcoseryl protection.

Animals↗
PubMed1978

Ultrastructural examination of blood dialysate effect in experimental carbon monoxide poisoning of the heart muscle.

The effects of acute carbon monoxide poisoning on the ultrastructure of the muscle had been investigated. Dogs were exposed to 10.1 vol.% carbon monoxide by intracoronary perfusion for 10, 20 and 30 min. The ultrastructural changes and cytochrome-oxidase activity reduction were evident after 10 min and were most prominent after 20 and 30 min. Degenerative changes of mitochondria, pericapillary and interfibrillar edema, sarcoplasmic reticulum dilatation, glycogen content decrease and in local areas a total or partial necrosis of myofibrils could characteristically be observed. The cytochrome-oxidase and glycose-6-phosphate dehydrogenase showed a significant decrease. A dialysis concentrate from deproteinised calf blood (Solcoseryl, Actihaemyl) proved to inhibit morphological and enzymatical pathological changes; the destruction was slowed and prevented. On this basis the protective effect of Solcoseryl may be of considerable importance.

Animals↗
PubMed1978

Comparative polarized-light and electron microscopic studies of changes in the structure of the intercalate disc following various experimental lesions.

The intercalate disc was studied following various traumatizing interference (cyanide, carbon monoxide poisoning, intermittent coronary perfusion, nitrogen perfusion, intermittent hypoxic loading, direct electric trauma). The most frequent alterations were the separation, vesicular transformation and loss of electron-dense material of the fascia adherens and occludens of the junctions. In extreme situations the lysis of filaments joining to the junctions and the rupture of the membrane was observed. Total desintegration of the intercalate disc was rarely encountered probably due to the high adhesive capacity of desmosomes. Topooptical reactions were found suitable to detect functional changes.

Animals↗
PubMed1977

[Use of the internal mammary artery in myocardial revascularization].

A total of 3409 cadavers was studied for changes of the internal mammary artery; sclerosis stenosis and occlusion of the vessel were quite exceptional. This fact is believed to be of importance from the aspect of myocardial revascularization by mammary-coronary anastomosis. Anastomoses were performed on cadavers; the vessels 1.5 to 2.5 mm in diameter were easy to suture.

Adult↗