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Biomedical subjects

A Nagano

Publications and source records attributed to A Nagano.

90 records · Page 5Linked to original sources
PubMed1988

Tibial lengthening by epiphyseal distraction.

Tibial lengthening by slow distraction of the distal epiphysis using the dynamic axial fixator was performed in 3 patients near to skeletal maturity, in 2 patients with congenital origin and in one with achondroplasia. The obtained lengths were 4.4 cm (17% of the tibial length), 3.7 cm (12%) and 3.6 cm (19%). There were no serious complications. Bone formation at the site of distraction was thought to be periosteal in origin when assessed using X-rays and computerized tomography. There was no radiological evidence that bone at the distracted sites was formed by an apposition from the metaphyseal side which is expected in cases of stimulation of endochondral ossification in the growth plate. There was no further measurable growth at the distracted growth plates after lengthening. This method is useful for limb lengthening near the time of epiphyseal closure.

Adolescent↗
PubMed1984

Brachial plexus injuries. Prognosis of postganglionic lesions.

One hundred ninety-eight cases of postganglionic brachial plexus injury with no signs of combined damage to preganglionic sites were treated conservatively. Among them, 50 whole, 32 upper and 13 lower type injuries were followed up for at least 2 years and the course of the progression of the individual muscle was observed. In the whole type, 44% showed good functional recovery, although some of them needed reconstructive surgery. Thirty-eight percent recovered usefully only in the muscles innervated by upper roots. Three out of 50 cases did not recover at all. There were no particular differences between the whole and upper types with regard to the recovery rate of the arm muscles. However, the upper type showed better functional recovery than the whole type. If the muscles innervated by upper roots could gain a strength of M1 before 9 months after injury, and muscles innervated by lower roots reached M1 before 12 months, their final results were more than M3. But muscles with a strength of less than M2 at 18 months did not recover to more than M3. The muscular power at 24 months was almost the same as the final results. About half of the postganglionic brachial plexus injuries which did not combine preganglionic lesions showed favorable spontaneous recovery with conservative treatment. At the exploration of the brachial plexus, if the somatosensory evoked potential test is positive, which negates the possibility of root avulsion, and also if there is no definite discontinuity of the postganglionic nerves, it should be treated conservatively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1982

Investigation of brachial plexus injuries by intraoperative cortical somatosensory evoked potentials.

With the intention of estimating the extent and site of damage in brachial plexus injuries which involve close to the root outlet and also the distal portion, cortical somatosensory evoked potentials (SEP) were recorded in 21 patients by directly stimulating the exposed brachial plexus. In 38 avulsed nerve roots which showed positive sensory action potentials (SNAP)/nerve action potentials (NAP) in their peripheral part, 15 roots (nine patients) were apparently in continuity and confirmed as root avulsion injury by the absence of cortical SEP. However, 11 roots (ten patients) which showed neither SNAP nor SEP would suggest either extensive lesions involving root and more distal segment or a combination of root avulsion and postganglionic injury. Fourteen patients who showed a positive Tinel's sign had at least one root with a postganglionic type lesion, but cortical SEP evoked by stimulation of the most proximal root zone sometimes revealed a reduced amplitude and prolonged latency. This would indicate the retrograde extension of damage. To confirm the extent and degree of the nerve lesions in brachial plexus injuries, an intraoperative SEP and NAP recording is very useful, practical, and also indispensable.

Adolescent↗
PubMed1981

[An experimental study on the functional recovery of denervated muscles--effects of stump rotation in nerve suture (author's transl)].

There are many factors which affect the end result of nerve suture. Clinically it is said tht rotation of the stumps at suture site has an unfavorable effect upon functional recovery, owing to discrepancies of funicular patterns and inappropriate funicular approximation. In order to evaluate the effect of rotation of the stumps at suture sites, tibial nerves of thirty-three full grown rabbits were used. After the tibial nerve was cut at a point three cm proximal to the popliteal fossa, in one group (20 rabbits) the nerve was sutured without rotation (0 degrees group) and in another group (19 rabbits) with 180 degrees rotation of the proximal stump (180 degrees groups), using epineural technique under operating microscope. Six months later return of nerve function was evaluated electrophysiologically and histologically. Electrophysiological measurements included electromyography, motor conduction velocity and muscle strength stimulating proximal stump. Histological evaluation following weighing included H-E stain, DPN diaphorase stain for muscle and Cajal stain for axon. There were no significant differences between the two groups with regard to the passage rate of axons at the suture site, motor conduction velocity or recovery rate of muscle weight. But muscle strength of the plantaris in the 180 degrees group was significantly weaker than that of 0 degrees group, and in the 180 degrees group, recovery rate of muscle strength was lower than that of muscle weight, though they were the same in the 0 degrees group. Histochemically there was marked fibre type grouping of the reinnervated muscle in both groups. The author concluded that in the rabbits, the rotation of nerve stumps at suture site does not affect the passage rate of axons at the suture site nor maturation of the axon. However, it does impose unfavorable influence upon functional recovery. Further problems may arise for the recovery of complex functions when reconstitution of proprioceptive feed-back system is considered.

Action Potentials↗
PubMed1977

Meitens' syndrome.

This paper reports on Mietens' syndrome which is characterized by mental retardation, growth failure, flexion contracture of the elbows, dislocation of the radius, abnormally short ulna and radius, bilateral corneal opacity, horizontal and rotational nystagmus, strabismus and a small pointed nose with depressed root. This is the second on the Mietens' syndrome.

Abnormalities, Multiple↗
PubMedDate not supplied

A case of Satoyoshi's syndrome.

Satoyoshi's syndrome is a rare neurologic disorder characterized by progressive muscle spasms, alopecia, diarrhea, and skeletal abnormalities. We describe a 21-year-old woman with Satoyoshi's syndrome whose skeletal changes were followed for 15 years until after she had reached skeletal maturity. The patient developed slipping of the epiphyses in the proximal humeri and femurs and metaphyseal lesions mimicking metaphyseal chondrodysplasia. These lesions were a consequence of physeal injuries caused by the recurrent muscle spasms.

Alopecia↗
PubMedDate not supplied

Helicobacter pylori of the remnant stomach and its eradication.

BACKGROUND/AIMS: Many authors have reported that Helicobacter pylori (H. pylori) is one of the major causes of gastritis and peptic ulcer. This study was conducted to evaluate the incidence of H. pylori infection and the curative effects of amoxicillin and omeprazole on H. pylori in the remnant stomach. METHODOLOGY: Biopsy specimens were obtained from 70 patients who underwent gastrectomy for gastric cancer. H. pylori was subsequently diagnosed by CLO test and culture of H. pylori. Gastritis was assessed by the scoring of four characteristic pathological parameters. Patients with positive H. pylori were eligible for the eradication study. Amoxicillin, 750 mg per day for 2 weeks, and omeprazole, 20 mg per day for 8 weeks, were administered to them. Endoscopic reexamination was performed 12 weeks after the initiation of treatment. RESULTS: The overall positive rate of H. pylori was 37.1%; 39.6% in Billroth I reconstruction, 0% in Billroth II reconstruction, and 55.6% in pylorus preserving gastrectomy, respectively. The positive H. pylori rate of Billroth II reconstruction was significantly low. However, there was no association of positive rate of H. pylori with time. There was no significant difference of gastritis scores between H. pylori infected patients and non-infected patients. The eradication rate was 70.0%. CONCLUSIONS: H. pylori was present in 37.1% of patients who underwent gastrectomy. Gastritis was not significantly severe in H. pylori infected patients. The treatment with amoxicillin and omeprazole was effective for these patients.

Aged↗
PubMedDate not supplied

Brachyolmia: a report of two cases.

Brachyolmia is a rare form of skeletal dysplasia characterized by generalized platyspondyly without significant epiphyseal, metaphyseal, or diaphyseal changes in the long bones. Two cases of brachyolmia are reported: one of the Hobaek type, and another of the dominant type. One patient developed linear densities in the femoral necks: The manifestation is thought to be specific to the Hobaek type. Another patient had atlantoaxial instability and failure of ossification of the dens. These complications of brachyolmia have not been previously reported.

Atlanto-Occipital Joint↗
PubMedDate not supplied

Carcinosarcoma of the esophagus: three cases with immunohistological examination.

Carcinosarcoma of the esophagus is a rare malignant tumor with both carcinomatous and sarcomatous components. We present 3 cases of carcinosarcoma of the esophagus and discuss the histogenesis of the tumors. We performed immunohistochemical studies using various antibodies: anti-cytokeratin, anti-vimentin, anti-smooth muscle actin, anti-p53, and MIB 1 reacting with Ki-67 nuclear antigen.

Biomarkers, Tumor↗