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Biomedical subjects

A N Kudrin

Publications and source records attributed to A N Kudrin.

At least 73 records · Page 4Linked to original sources
PubMed1975

Combined administration of quinidine with the beta-adrenolytic agent inderal and the local anaesthetic of the beta-aminoketone group, hexacaine, in various experimental models of arrhythmias.

If the antiarrhythmic agents mentioned above are administered in combinations of their respective isoeffective doses, following the "principle of isoeffectivity", a potentiation of their effects takes place. The authors describe methods for the preparation of combined solutions and for the toxicity testing of combined antiarrhythmic agents. When combinations are administered, the toxicity does not increase but on the contrary tends to decrease. If antiarrhythmic agents are combined without regard to the principle of isoeffectivity, the antiarrhythmic effect of the combination deteriorates, and adverse effects may be produced. The basic prerequisite of the potentiation of antiarrhythmic effects in combinations is, in the authors' opinion, the use of drugs differing in both chemical structures and mechanisms of antiarrhythmic actions.

Anesthetics, Local↗
PubMed1975

[Interrelationship of the mediator receptors in the terminals of the afferent nerves of the cornea of the eye].

In local application of substances with a mediator action (adrenaline, acetylcholine, histamine) and blockers of specific receptors (dihydroergotoxin, inderal, atropine and of subcutaneous dimedrol) together with dicaine it was possible to reveal a distinct presence in the cornea of the eye of the mediator receptors capable of influencing one another. Pharmacological analysis permitted a supposition to be made that there were two receptor systems in the sensory nerve endings of the cornea; these systems were in reciprocal inhibitory relations; due to this their regular influence on the processes of excitation and inhibition is effected in the sensory nerve ending.

Acetylcholine↗