Search PubMed⌕ Search

Biomedical subjects

A N Kudrin

Publications and source records attributed to A N Kudrin.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Morphologic indices the influence of selenium and vitamin E on the course of experimental myocardial infarct].

Myocardial infarction was induced in rats by ligating a coronary artery. During a week they received daily injections of 50 mg/kg of vitamin E intramuscularly or 30 mug/kg of sodium selenite subcutaneously, or else a combination of these preparations. The control animals received no injections. Stereometrically a statistically significant reduction of the infarcted zone was noted under the effect of selenium, this reduction being especially distinct during the ischaemic stage; the maturation of granulation tissue with an enhancement of the fibroblast reaction therein was accelerated. The muscle cells of the myocardium beyond the infarction zone displayed an increased activity of lactate dehydrogenase and a reduced activity of succinate dehydrogenase, intactness of the ultrastructure of the cell pattern, an enhancement of the signs of ultrastructural regeneration. Vitamin E potentiated the effect of selenium and executed itself a similar, but less distinct effect.

Animals↗
PubMed1976

[Negative chrono- and inotropic effect of acetylcholine after its local administration to different parts of the heart].

The application of acetylcholine to the atria of an isolated heart of a frog produces a specific negative chronotropic effect without decreasing its amplitude, while its application to the ventricle -- a specific negative inotropic effect without decelerating the heart contractions rate. The application of atropine to the atria and ventricles eliminates the specific negative chrono- and inotropic effects of acetylcholine. The various ganglion-blocking agents do not eliminate these effects. The existence of a new membrane mechanism of perception of the specific effects of acetylcholine and of their synchronous transmission to the venous-atrial node and the ventricular myocardium is proved to be found in the atria and ventricles.

Acetylcholine↗