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Biomedical subjects

A Murat

Publications and source records attributed to A Murat.

At least 73 records · Page 4Linked to original sources
PubMed1988

Absence of receptors for thyrotropin (TSH)-releasing hormone in human TSH-secreting pituitary adenomas associated with hyperthyroidism.

In patients with TSH-secreting pituitary adenomas associated with hyperthyroidism, TSH secretion usually does not respond to exogenous TRH stimulation. To determine the basis for this unresponsiveness, we studied TRH binding to the membranes of two such TSH-secreting pituitary adenomas. The patients, a 28-yr-old man and a 60-yr-old woman, had clinical and biochemical hyperthyroidism with increased serum TSH levels (15.7 and 14 mU/L, respectively; normal range, 1.1-7.2) and alpha-subunit to TSH molar ratios greater than 1 (2.4 and 1.7, respectively). Neither patients had an increase in serum TSH in response to TRH (200 micrograms, iv). Immunocytochemistry of the two adenomas, removed by transsphenoidal surgery showed a pure population of thyrotropic cells. Binding studies were performed by incubation of tumor cell membrane suspensions with increasing amounts of [3H]TRH. Two PRL-secreting adenomas and one normal human pituitary were used as controls. The characteristics of the TRH-binding sites from the control tissues were similar to those previously reported (Kd, 56, 30, and 49 nM; maximum binding, 187, 46, and 94 fmol/mg protein, respectively). In contrast, no specific TRH binding was found in the two TSH-secreting adenomas. We conclude that the unresponsiveness of TSH after TRH administration is related to the absence of specific TRH-binding sites in these thyrotropic tumors.

Adenoma↗
PubMed1987

[Microalbuminuria is not a marker of diabetic retinopathy].

Microalbuminuria is considered a good predictor of diabetic nephropathy. In this study over 50% of patients with retinopathy, whatever its severity, did not show microalbuminuria. However, among patients with microalbuminuria, the percentage of retinopathy was significantly increased (75%). It is concluded that with the exception of nephropathy, microalbuminuria is not a good parameter for the detection of other microangiopathic complications of diabetes.

Adult↗
PubMed1987

[Neurotoxicity of mitotane therapy of adrenocortical carcinoma (5 cases) and Cushing's syndrome (7 cases)].

Twelve patients were treated with op'DDD over a 9-year period. All presented with mild neurological symptoms, and half of them had major complications. There was no relation between the occurrence of these symptoms and the dose or duration of op'DDD therapy. The mechanisms of this neurological toxicity, both central and peripheral, are not well known, but they appear to be similar to those of certain op'DDD-related chemicals used in industry.

Adolescent↗
PubMed1985

Influence of concentration on the kinetics of SC-infused insulin. Comparison between square-wave SC infusion and bolus SC injection.

The influence of various concentrations of a constantly SC-infused insulin solution on plasma free insulin (PFI) levels wa studied in eight type 1 diabetic subjects. Soluble insulin at three different concentrations (10, 40, and 100 U/mL) was pumped at two different rates: 1.5 U/h between meals and 15 U/h for 30 minutes just before meals. For each randomly allocated concentration, PFI levels were studied twice in the same day during two six hour postmeal periods. In addition, at the end of the U40 infusion, a comparable amount of insulin was injected as a bolus. The total amount (56 U/d) and distribution of insulin delivered were similar in all patients and with each concentration. The mean maximum PFI levels were 39 +/- 7.2, 28.4 +/- 3.4, 36.2 +/- 6.4, and 29.2 +/- 7.6 mus U/mL, respectively, during the U10, U40, and U100 infusions and the U40 bolus injection; these values were observed, respectively, 60, 120, 90, and 90 minutes after a step up increase of insulin infusion and after the SC bolus injection. PFI levels returned to basal values between three and five hours after the step decrease. There was no significant difference in the kinetics of PFI levels variation, whatever the concentration in the range of 10 to 100 U/mL. For U40 these kinetics did not differ from that observed after a bolus SC injection of soluble insulin.

Absorption↗
PubMed1985

[Radioimmunoassay of urinary albumin: early indicator of diabetic nephropathy?].

Microalbuminuria is now considered a good biological marker predictive of diabetic nephropathy. The degree of microalbuminuria was determined by radioimmunoassay in 23 controls and 50 insulin-dependent patients with poor control of glycaemia. Higher levels were found in diabetics, whatever the duration of the disease. At the moment, this difference, which is reversible with good metabolic control, can be explained by blood glucose balance. Several authors have established the existence of a microalbuminuria threshold predictive of nephropathy, but its level is controversial, chiefly on account of the urine collection methods.

Adolescent↗
PubMed1985

Bilateral phaeochromocytomas in pregnancy: anaesthetic management of combined caesarean section and tumour removal.

A 25-year-old primigravida with bilateral phaeochromocytomas was managed from 6 weeks' gestation until 2.5 years following combined Caesarean section and removal of adrenal tumours. Pre-operative alpha-blockade was achieved by oral prazosin without deleterious effects. Intra-operative management comprised neuroleptanalgesia, arterial and pulmonary pressure monitoring, adequate heart loading with fluid replacement and sodium nitroprusside. Post-operatively, mother and baby remained normotensive.

Adrenal Gland Neoplasms↗
PubMed1984

[Value of correlated immunofluorescence and immunoperoxidase study of monoclonal markers in 2 adult cases of histiocytosis X].

Two cases of adult histiocytosis X have been studied using monoclonal antibodies on skin sections by two techniques: indirect immunofluorescence and immunoperoxidase. This study confirm: --that histiocytosis X express two specific antigens Ia and T6, --the relations between Langerhans cell and histiocytosis X. Especially, it suggests that histiocytosis X cell would be a dedifferentiated cell with receptors OKT4 and OKT10.

Adult↗