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Biomedical subjects

A Munakata

Publications and source records attributed to A Munakata.

At least 145 records · Page 8Linked to original sources
PubMed1988

Serum and prostatic tissue concentrations of ofloxacin.

Serum concentrations of ofloxacin were determined in 28 patients, and prostatic tissue concentrations were analyzed in 26 patients, receiving a single 400-mg oral dose of the agent prior to transurethral prostatectomy. The maximum serum concentration was 5.198 micrograms/ml, the time of maximum concentration was 195.1 minutes, and the terminal half-life was 211.7 minutes. The prostatic tissue concentrations of ofloxacin were similar to those in serum (ratio, 1.06 +/- 0.37).

Administration, Oral↗
PubMed1988

Mortality after transurethral prostatectomy.

In 68 patients aged 80 to 94 who underwent transurethral prostatectomy between 1981 and 1987, the survival rate after the procedure was higher than that of the general population of the same age distribution. In nine patients aged 62 to 92 for whom transurethral prostatectomy was indicated but not performed because of concomitant medical problems (including cardiac problems in four, advanced cancer in two, dementia in two, and pulmonary disease in one), the survival rate was much lower, seven of the nine dying within 13 months. High mortality reported in men undergoing transurethral prostatectomy may be due to concomitant medical problems rather than aftereffects of the surgery.

Actuarial Analysis↗
PubMed1985

An immunologic test for fecal occult blood by counter immunoelectrophoresis. Higher sensitivity and higher positive reactions in colorectal cancer than single radial immunodiffusion and hemoccult test.

A new immunologic fecal occult blood test has been developed employing counter immunoelectrophoresis (CIEP) with anti-human hemoglobin Ao antiserum (anti-HbAo). Minimum detectable hemoglobin in hemolysate was 7, 9, and 7 micrograms/ml by CIEP, single radial immunodiffusion (SRID), and Hemoccult test (SmithKline Beckman), respectively. The values in stool were 0.5, 1.0, 3.0 mg hemoglobin/g stool in the same order. CIEP was more sensitive than SRID in detecting hemoglobin both in hemolysate and in feces. Of 38 stools from the patients with colorectal cancer, 29 (76%) gave positive tests in CIEP, whereas 22 (58%) (P less than 0.005), and 18 (47%) (P less than 0.05) gave positive tests in SRID and Hemoccult test, respectively. In every stage and at every site of cancer, CIEP showed the highest positive tests. CIEP did not give any false-positive reaction in specimens from 20 patients without gastrointestinal lesion or from 34 asymptomatic healthy controls without diet restriction, whereas Hemoccult test gave one and three positive reactions in these groups. These results clearly indicate that CIEP is specific and more sensitive to human hemoglobin than any other previous methods. CIEP is expected to have a potential for mass screening of colorectal cancer.

Colonic Neoplasms↗
PubMed1984

An unusual case of colonic leiomyosarcoma presenting with fever--significant uptake of radioactivity of gallium-67 in the tumor.

Leiomyosarcoma of the large intestine, excluding the rectum, is a rare lesion and only 58 cases have been previously reported. Significant uptake of radioactivity of gallium-67 to the tumor has not been reported and this report may be the first case. Although preoperative diagnosis is considered to be difficult, barium enema study and colonofiberscopy disclosed the findings suggesting extracolic growth of the tumor in our case, which are thought to be characteristics of nonepithelial tumors. Gallium-67 citrate scanning may be useful for confirming the diagnosis.

Adult↗
PubMed1981

Anti-spasmodic effect of prifinium bromide on the proximal and distal colon in patients with diverticular disease.

In 5 patients with diverticular disease, colonic motilities of the proximal and distal colon were recorded using the ERBI method. The motilities were studied during resting, after prostigmin 0.5 mg i.m. injection and after prifinium bromide 7.5 mg i.m. injection, with the following results: After prostigmin colonic motility of the proximal colon became significantly greater than that of the distal colon. Prifinium bromide inhibited the prostigmin-induced hypermotility markedly. It was demonstrated that this drug has an antispasmodic action not only on the distal colon but also on the proximal colon. Prifinium bromide was an antispasmodic drug which brought about a rapid effect which appears within 3 minutes after injection. The effect persisted for about 1 hour.

Colon↗
PubMed1975

Statistical analysis of diverticulosis of the colon.

Forty-four cases of diverticulosis of the colon were detected among 2,662 cases examined by barium enema in Tohoku University. This corresponds to 1.7% in frequency. On the other hand, 21 cases were found among 1,511 cases examined in Hirosaki University, giving 1.4% in frequency. It was more frequent in the male. The frequency, as calculated on the basis of the numbers of cases examined by barium enema in separate age groups, showed the gradual increase with age except for above the eighth decade. The location where the diverticulum was most frequently seen was the right colon; namely, cases in which the diverticulum occurred from the cecum to the ascending colon and those in which it was found only in the ascending colon occupied 61.4 and 71.4% of the total cases, respectively. Diverticulitis as a complication was rare, while coincidence of polyp or carcinoma was sometimes observed. Furthermore, the value of fiberscopy for the diagnosis of diverticulosis of the colon was discussed, and its usefulness for the detection of complication was emphasized.

Adult↗