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Biomedical subjects

A Moriya

Publications and source records attributed to A Moriya.

48 records · Page 3Linked to original sources

[A case of congenital mesoblastic nephroma growing with a polypoid pattern in the renal pelvis and ureter].

Congenital mesoblastic nephroma (CMN) is an unusual renal tumor, similar in some respects to Wilms' tumor and reported only in infants. We report a case of CMN in a 2-year-old boy. He was referred to us with a right abdominal mass. Excretory urogram, arteriogram and computed tomogram revealed a large malignant renal tumor on the right side. With a clinical diagnosis of Wilms' tumor of the right kidney, he received radiation and chemotherapy. After radiation and chemotherapy, tumor size was decreased. Right nephrectomy was performed on April 22, 1982. The kidney and tumor weighed 270 g and measured 12 X 7 X 5 cm. The tumor extended to the renal pelvis and the ureter with polypoid growth pattern. Microscopically, the tumor was composed of compact interlacing bundles of elongated fibromyomatous cells. Islands of entrapped glomeruli and tubules were also detected within the tumor. He was well and had no signs of recurrence of tumor at the age of 3 years.

Child, Preschool↗

[Experience of renal autotransplantation].

We present 2 cases with renovascular hypertension treated by renal autotransplantation and 3 cases with extensive renal calculi treated by renal bench surgery and autotransplantation. The cases with renovascular hypertension were due to fibromuscular dysplasia in the trunk of renal artery, and return to normotension and improvement of renal function were obtained within a few days after the operation. In 2 of the cases with extensive renal calculi, the contralateral kidney was contracted. In all cases, the stones were removed completely and urinary tract infection persisting before operation was eradicated. The postoperative renal function was well preserved and no recurrence of renal calculi was observed throughout the follow up period. The indication of renal bench surgery and autotransplantation was discussed both for renal calculi and renovascular hypertension.

Adult↗

[Experience with microsurgical two-layer vasovasostomy].

Excellent results of vasectomy reversal have been reported by Silber and Owen in 1977 using microsurgical technique without splints. Herein, we report two cases of male sterility due to previous voluntary vasectomy in which fertility was restored by microsurgical vasovasostomy. The reason for vasectomy reversal in these cases was a subsequent marriage. Case 1: A 36-year-old male who had had vasectomy 3 years earlier, underwent vasovasostomy on September 20th 1976. The sperm granuloma was not found, but sperm was observed in the fluid from the proximal cut-end of the vas deferens at the time of operation. He fathered a baby on October 2, 1977. Case 2: A 43-year-old male who had had vasectomy 10 years ago underwent vasovasostomy on February 5th 1980. Sperm granuloma was observed at the time of operation. He fathered a baby on February 25th 1981. The important factors that determine the success of vasectomy reversal are the method and time of reversal. 1) Microsurgical two-layer vasovasostomy is the most reliable method among the various operations for vasectomy reversal. 2) A shorter duration between vasectomy and it's reversal, and the existence of sperm granuloma after previous vasectomy increase the possibility to restore fertility.

Adult↗

[Effect of carboquone (esquinone) on the development of urinary bladder tumors in rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine].

The effect of carboquone (CQ) by intraperitoneal administration on the development of urinary bladder tumors in Wistar strain male rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was studied. Urinary bladder tumors were induced in 9 of 11 rats (81.8%) when they were given 0.05% BBN in drinking water for 8 weeks and then given water without BBN for 12 weeks. When CQ 0.25 mg/kg/day was administered intraperitoneally for 7 days after treatment with 0.05% BBN for 8 weeks, incidence of urinary bladder tumors was 19 of 26 rats (73.1%). When CQ 0.25 mg/kg/weekly was given for 12 weeks after treatment with BBN, incidence of urinary bladder tumors was 17 of 27 rats (63.0%). When CQ 0.5mg/kg. B.W./day was given for 7 days after treatment with BBN, tumors developed in the urinary bladder with low incidence as in 8 of 20 rats (40.0%) (P 0.1). When CQ 0.5mg/kg/weekly was given for 12 weeks after treatment of BBN, urinary bladder tumors were induced in 17 of 22 rats (77.3%). Hematotoxity was not observed in any animals treated with CQ. These results showed that CQ inhibited the development of urinary bladder tumors induced by BBN in rats.

Animals↗