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Biomedical subjects

A Moreno

Publications and source records attributed to A Moreno.

At least 469 records · Page 26Linked to original sources
PubMed1985

Regulation of amino acid transport system L by amino acid availability in CHO-K1 cells. A special role for leucine.

Starvation of CHO-K1 cells for leucine leads to a 3-4-fold increase in transport system L activity, without modification of transport through systems A and ASC. The concentration of leucine must be below 10 microM before the enhancement of transport can be clearly seen. To achieve low concentrations of leucine such as 10 microM, extensive dialysis of fetal calf serum was required. The enhancement of transport was completed after 12-24 h of starvation and was fully reversed within 1 h of re-feeding with leucine. Starvation for isoleucine, valine or phenylalanine also produced an increase in system L transport activity, but the effect was only one half of that seen following leucine starvation.

Amino Acids↗
PubMed1985

Cutaneous angiomas in POEMS syndrome.

POEMS syndrome is an unusual plasma cell dyscrasia with multisystemic manifestations featuring polyneuropathy, organomegaly, endocrinopathy, M protein and constant skin involvement. We have seen a 58-year-old white man presenting with generalized eruptive angiomas as a rare skin manifestation of this syndrome. We review the literature and discuss the pathogenesis of vascular proliferation in this unusual entity.

Cardiomegaly↗
PubMed1985

Cutaneous reactions secondary to heparin injections.

Ten to 20 days after starting prophylactic doses of heparin in six patients, large, indurated, erythematous plaques appeared at the sites of the subcutaneous injections. Pruritus, local tenderness, and burning sensation or pain were present. No skin necrosis developed. Heparin was discontinued and topical corticosteroids were applied to the involved areas. Five to 9 days later the lesions had resolved completely. The reaction seen in the six patients is similar to the early erythematous phase of the so-called heparin necrosis. There is a spectrum of cutaneous changes ranging from mild erythematous pruritic areas to large symptomatic plaques and to heparin necrosis, following subcutaneous injections of heparin.

Aged↗
PubMed1985

A cystic teratoma in skin.

This is a report of a child who had a subcutaneous cyst that was filled with cornified cells and hair and lined by respiratory epithelium with seromucous glands and partly by squamous epithelium like that of the follicular infundibulum to which epithelial structures of adnexa were attached. The cyst wall was encircled incompletely by fascicles of mature smooth muscle. Differential diagnosis is discussed and cystic teratoma in skin is suggested as a proper term for the condition.

Child, Preschool↗
PubMed1985

Tobramycin and amikacin nephrotoxicity. Value of serum creatinine versus urinary concentration of beta-2-microglobulin.

108 patients who received tobramycin or amikacin could be evaluated for nephrotoxicity in a prospective randomized trial. Both groups had similar illnesses, and causative agents, concurrent drug administration, ages, sex ratios, initial serum creatinine and aminoglycoside levels and total dose and duration of therapy. Using urinary concentration of beta 2 microglobulin (beta 2m) as a marker, nephrotoxicity was detected in 13 (22.4%) of 58 patients given tobramycin and 13 (26%) of 50 given amikacin (n.s.). Using serum creatinine as a marker, nephrotoxicity was detected in 3 (5.2%) of 58 patients given tobramycin and in 7 (14%) of 50 given amikacin (n.s.). The whole group of 108 patients was used to compare the usefulness of serum creatinine levels versus urinary concentration of beta 2m. An elevation of serum creatinine was detected in 10 of 108 patients (9.3%). In 5 of these 10 patients the beta 2m remained normal, suggesting a functional renal failure. In 21 of the 108 patients (19.4%) the beta 2m increased while the serum creatinine remained normal, suggesting an aminoglycoside nephrotoxicity which would have remained undetected if only serum creatinine had been measured. In the remaining patients (77 of the 108; 71.3%) serum creatinine and urinary concentration of beta 2m both remained normal throughout the treatment. In conclusion no statistically significant differences were found between tobramycin and amikacin nephrotoxicity. Urinary beta 2m is more sensitive than serum creatinine and furthermore it allows one to differentiate aminoglycoside nephrotoxicity from functional renal failure.

Adult↗
PubMed1985

Multiple fibrofolliculomas and trichodiscomas.

A late-onset, sporadic case of multiple fibrofolliculomas and trichodiscomas is reported. This case and other reports in the literature suggest to the authors that benign neoplasms derived from the mesodermal component of the pilar apparatus may present in various combinations and may also be associated with other hamartomatous skin proliferations. The wide spectrum of published combinations may be due to similarities in clinical presentation and biopsy-sampling uncertainties.

Hair Diseases↗
PubMed1985

Polymorphic eruption of pregnancy: histopathologic study.

The microscopic findings in 31 biopsies of patients with polymorphic eruption of pregnancy are reported with a literature review. Cutaneous changes include edema, dermal lympho-histiocytic infiltrate and epidermal lesions. We have found a correlation between the intensity of the inflammatory response and the presence of epidermal involvement. In our opinion, the histopathological changes may allow an accurate diagnosis with the adequate clinical information. Direct immunofluorescence did not reveal immunoglobulin or complement deposits in the ten cases studied. It may help in the differential diagnosis with nonbullous herpes gestationis.

Adolescent↗
PubMed1985

Septal granulomatous panniculitis in Sweet's syndrome. Report of two cases.

Two patients had Sweet's syndrome (acute febrile neutrophilic dermatosis) with subcutaneous lesions resembling erythema nodosum. In both, the erythema nodosum--like lesions histologically showed a septal granulomatous panniculitis with numerous Miescher's granulomas. This type of subcutaneous involvement in Sweet's syndrome should be differentiated from panniculitis caused by deep subcutaneous neutrophilic infiltration. Involvement of the panniculus in Sweet's syndrome may then occur in two different patterns: a septal granulomatous panniculitis, as in our two cases, or a neutrophilic lobular panniculitis, as has been previously reported.

Adult↗