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Biomedical subjects

A Moreno

Publications and source records attributed to A Moreno.

At least 451 records · Page 25Linked to original sources
PubMed1987

[Monoclonal antibodies in pigmented lesions].

We have applied a battery of murine monoclonal antibodies (R-24, L-101, S-171) to the immunohistological diagnosis of 35 pigmented lesions. The results of our study allow us to conclude that: 1) The monoclonal antibody R-24 is a good marker of normal and neoplastic melanocytes, although some melanomas do not stain with this monoclonal antibody. The application of R-24 may contribute to the pathologic differential diagnosis of melanoma metastases. 2) The association of R-24+ and L-101+ staining is found in melanocytic nevus as well as in melanomas, and do not allow the differential diagnosis between them. 3) Stains with R-24, L-101 and S-171 are simultaneously positive only in melanomas, and with low frequency.

Antibodies, Monoclonal↗
PubMed1987

Digitoxin elimination in healthy subjects taking ampicillin.

The present study was carried out to evaluate the changes in digitoxin kinetics during ampicillin administration. Subjects were informed of the nature of the study and the treatment was applied to those who gave their written consent. Six healthy volunteers received a single oral dose of 1.0 mg of digitoxin. Three days later, they were given orally ampicillin trihydrate, 500 mg four times daily, for five consecutive days. Blood samples were taken at 24, 36, 48, 60, 72, 96, 120, 144, 168 and 192 hours after digitoxin. Compliance with ampicillin regimen was verified by fluorimetric measurement of serum ampicillin. Concentrations of serum digitoxin were determined by radioimmunoassay. The mean digitoxin elimination half-life changed from 162.8 +/- 12.9 h before to 181.3 +/- 10.1 h (mean +/- s.e. mean) after ampicillin. These differences were not significant. No consistent evidence of a kinetic interaction between digitoxin and the broad-spectrum antibiotic ampicillin was found.

Adult↗
PubMed1986

Prognostic factors in laryngeal carcinoma. A multifactorial study of 416 cases.

The prognostic significance of 20 clinical and histologic parameters was evaluated in a series of 416 laryngeal carcinomas treated between 1969 and 1981 at the Hospital de Santa Cruz y San Pablo, Barcelona, Spain. Clinical follow-up ranged from 2 to 13 years. The variables considered were: age, smoking habits, previous laryngeal disease, duration of clinical symptoms, motility of vocal cords, interval between diagnosis and treatment, postoperative infection, topographic location of the tumor, previous tracheostomy, ulceration, tumor size, resection margins, histologic grading, patterns of growth, types of invasion, mitotic index, depth of invasion, positive lymph nodes, T categories and N categories. Fourteen parameters were found to be significantly related to survival. After a multifactorial study using Cox's life table regression model, 5 of those 14 parameters were found to influence survival independently. The five variables ordered according to prognostic significance were: (1) positive lymph nodes, (2) T categories, (3) histologic grading, (4) ulceration, and (5) location.

Actuarial Analysis↗
PubMed1986

Leiurus quinquestriatus venom inhibits different kinds of Ca2+-dependent K+ channels.

A minor protein component of Leiurus quinquestriatus venom has been reported to inhibit selectively the apamin-insensitive Ca2+-dependent K+ channels of mammalian skeletal muscle (Miller, C., Moczydlowski, E., Latorre, R. and Phillips, M. (1985) Nature 313, 316-318). We report the effect of the venom on both the apamin-insensitive channels of the human erythrocyte, the Ehrlich cell and the rat thymocyte and the apamin-sensitive channel of the guinea pig hepatocyte. The venom inhibited Ca2+-dependent K+ transport in all the cases with a Ki value within the range of 1 to 10 micrograms/ml, similar to that reported previously in muscle. Valinomycin-induced K+ transport was also antagonized by the venom but its sensitivity was about 1/10 as much as that of the Ca2+-dependent K+ channel.

Apamin↗
PubMed1986

Long survival of diarrhea-associated hepatocarcinoma treated with Adriamycin and indomethacin. A case report.

The existence of tumors producing prostaglandins is well documented in the literature. At present, no case report of a prostaglandin-producing hepatocellular carcinoma has been published, to our knowledge. The authors report a patient with hepatocellular carcinoma associated with diarrhea mediated by prostaglandins, surviving 30 months after receiving treatment with indomethacin and Adriamycin. The authors will discuss the possible role played by indomethacin in the exceptional clinical course of the patient.

Adult↗
PubMed1986

Granulation tissue proliferation during isotretinoin treatment.

Excessive, pseudotumoral granulation tissue proliferations appeared in three patients receiving isotretinoin for nodulocystic acne. A review of the literature disclosed few reports of this unusual adverse reaction. Two clinical patterns have been reported; one in a periungual location and the other occurring in the sites of acne lesions during isotretinoin therapy. Loose edematous connective tissue with small vessels and chronic inflammatory infiltrate were the histologic findings in all three cases.

Acne Vulgaris↗
PubMed1986

Infiltrating angiolipoma: report of two cases and review of the literature.

Infiltrating angiolipoma is an infrequent cutaneous tumor, with skeletal muscle infiltration that should be differentiated from the common encapsulated angiolipoma. We present two cases in young women, and review the literature. Infiltrating angiolipoma may be a locally aggressive neoplasm, which makes its clinicopathologic recognition and appropriate therapy important.

Adult↗
PubMed1986

Osteoid and bone formation in desmoplastic malignant melanoma.

A 77-year-old man presented a recurrent subungual malignant melanoma with desmoplastic features in which heterotopic bone had developed. Histological, histochemical and immunohistochemical findings confirmed the diagnosis of malignant melanoma. Electron microscopic findings suggest that desmoplasia is the result of fibroblastic differentiation of spindle melanoma cells.

Aged↗
PubMed1986

[Fibroma of the tendon sheath].

Fibroma of the tendon sheath (FTS) is a rare benign soft tissue tumor. Its location and clinical findings may be similar to the giant cell tumor of tendon sheath or to infantile digital fibromatosis. Accurate diagnosis of FTS depends on microscopic examination of the excised tumor. The present report deals with two cases.

Adult↗