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Biomedical subjects

A Moore

Publications and source records attributed to A Moore.

At least 379 records · Page 21Linked to original sources
PubMed1977

Transfers to a psychiatric emergency room: a fresh look at the dumping symdrome.

There can be considerable interinstitutional distrust regarding transfer of psychiatric patients. In 1970 the directors of all psychiatric hospitals in New York City began to meet regularly in order to define problems and work out amicable resolutions, largely by defining criteria for hospitalization, establishing correct catchment area address, etc. In order to test the success of the program, three medical centers which routinely transfer patients to a receiving hospital were studied in order to see if they misrepresented patients' psychopathology or medical problems prior to transfer. It was found that 90% of the transfers were warranted, but that preselection at the hospital or origin led to the transfer of more males than females and more assaultive, rather than quieter patients, who might have been more amenable to inpatient treatment.

Concurrent Review↗
PubMed1977

Myosin in cultured human endothelial cells.

Myosin was isolated from cultured human endothelial cells by extraction with 0.6 M KCl and chromatography on Sepharose 4B. The extracted endothelial cell protein was identified as myosin by the characteristic ATPase profile, that is, the ATPase was activated by Ca2 + and EDTA and inhibited by Mg2 +. On sodium dodecyl sulphate polyacrylamide gel electrophoresis, the endothelial cell myosin heavy chain migrated with a molecular weight of 200 000 as did rabbit uterine and human platelet myosin heavy chains. A crude preparation of the endothelial cell myosin reacted immunologically with an antiserum to platelet myosin, a smooth muscle type of myosin. In indirect immunofluorescence studies, antiserum to the purified endothelial cell myosin stained cultured endothelial cells in a fibrillar pattern. The fibrillar pattern was more intense when the endothelial cells were stained with antiserum to platelet myosin. The presence of myosin in the endothelial cell provides a basis for the contractility of these cells. This contractile property may plan an important role in the physiologic function of these cells.

Adenosine Triphosphatases↗
PubMed1977

Electrolyte pH changes in Human Milk.

Milk samples from 100 lactating mothers in the 10 days following delivery have been analyzed for pH, sodium, and potassium. The sodium concentration was high in the first 5 days, mean 21 +/- 5 mmol/liter, but fell to a mean 15 mmol/liter by the end of the first week and 12 mmol/liter by the 10th day. A similar downward trend was shown for potassium with an initial mean concentration of 18.5 mmol/liter falling to 15 mmol/liter by the 10th day. The pH fluctuated widely from day to day through a range of 6.75-7.42 with a mean pH 7.09. Considerable variations were shown in individuals from day to day, and from the beginning to the end of feeds (Table 1). The relatively high sodium concentration in the first few days may be an important defense mechanism against dehydration and hyponatremia during a period of relative thirst and starvation. The variation in the pH and electrolyte content of human milk may be expected to have some influence on the acid-base and electrolyte status of the infant.

Female↗
PubMed1976

Finger Clubbing: A quantitative survey by analysis of the shadowgraph.

Finger-clubbing has been measured from the magnified silhouette of the right index finger (shadowgram) in 125 subjects, comprising children and young adults. The profile and hyponychial angles were both found to be good discriminators of clubbing and to be independent of age and sex. The normal profile angle was 168.3 degrees +/- 3.6 and the mean normal hyponychial angle was 180.1 degrees +/- 4.2. Patients with cystic fibrosis and cyanotic congenital heart-disease were found to have grossly elevated values of these angles. Some asthmatics were found to have a moderate degree of clubbing with significantly elevated values of these angles. The shadowgram proved a convenient objective method for recording the degree and progress of fingerclubbing in clinical practice.

Adolescent↗
PubMed1976

Luteinizing hormone-releasing hormone for induction of follicular maturation and ovulation in women with infertility and amenorrhea.

Five patients with primary infertility and secondary amenorrhea who did not respond to clomiphene with a gonadotropin or estrogen surge were treated with 500 mug of luteinizing hormone, follicle-stimulating hormone-releasing hormone (LH-RH), self-administered subcutaneously every 8 hours for 14 days. Of four patients who responded to this treatment, three showed follicular maturation, ovulation, and menses, although the luteal phase was deficient; in the fourth patient, follicular maturation and menses occurred without evidence of ovulation. For their second course of treatment these four patients were given LH-RH with the addition of human chorionic gonadotropin when the urinary estrogen levels indicated follicular maturation. All four patients responded with ovulation, an adequate luteal phase, and menses, without clinical indication of ovarian hyperstimulation. These results suggest that LH-RH may be a better alternative to human menopausal gonadotropin in the treatment of anovulatory infertility.

Adult↗
PubMed1976

Further studies on angiotensin tachyphylaxis.

Rabbit aorta and rat fundus do not display tachyphylaxis to angiotensin II (Asp1)angiotensin II) at 37 degrees C. These tissues do, however, display tachyphylaxis to [Sar1]angiotensin II (N-methylglycine 1 angiotensin II) and [dimethylglycine angiotensin II, respectively, at this temperature. At 22 degrees C, both tissues displayed rapid tachyphylaxis to [Asp1]angiotensin II which was reversed on prolonged incubation in peptide-free medium. At 37 degrees C, but at a lower than normal pH (pH 6.5 instead of 7.4), the rabbit aorta developed rapid tachyphylaxis to [Asp1)angiotensin II; this effect also was reversed on prolonged incubation in peptide-free medium. The rat uterus, at 30 degrees C, displayed tachyphylaxis to [Asp1]angiotensin II and analogs in order of rate of onset: [Sar1]angiotensin II greater than [Asp1]angiotensin II greater than [des-Asp1]angiotensin II. Over half of the individual uterine strips tested displayed no tachyphylaxis to [des-Asp1]angiotensin II. However, at 22 degrees C tachyphylaxis to all three compounds was rapid on onset and was reversed on prolonged incubation. The results indicate a correlation between affinity of the peptide analog for angiotensin receptor and its ability to induce tachyphylaxis. A possible involvement of membrane-bound enzymes in the onset and duration of tachyphylaxis is suggested.

Angiotensin II↗
PubMed1972

Doctors' fees.

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Australia↗