Biomedical subjects
Publications and source records attributed to A Monaco.
The lines of maximal tension are parallel to the skin creases, or lines of cleavage, as described by Langer. This study verifies that incisions in the foot produce the least amount of scarring when made parallel to the lines of minimal movement. Incisions made perpendicular to these cleavage lines produce maximal scarring, and oblique incisions produce an intermediate amount of scarring.
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The effect of dietary protein content on the diurnal variations in plasma neutral amino acid levels was studied in normal human subjects. For 3 consecutive 5-day periods, subjects consumed diet containing 0-or 75 or 150 g of protein per day. Blood samples were drawn at 4-hr intervals on the 4th and 5th days of each period. Consumption of the protein-free diet caused plasma concentration of all amino acids in the late morning and afternoon, while the 150 g protein diet elicited increases in these levels during the daytime. Ingestion of the diet containing 75 g protein tended to diminish the amplitude the daily rhythms.
The ratios of plasma tryptophan, tyrosine and phenilanine levels to the sum of other large neutral amino acids are reported. They tended to fall as the protein content of the diet was increased. The isoleucine ratios were not correlated with dietary protein content. Since diet-induced changes in plasma tryptophan and tyrosine ratios in animal are known to cause parallel alterations in brain tryptophan and tyrosine and levels, and thus in the rates of brain serotonin and catecholamines synthesis, out data suggest that the ingestion of carbohydrates and protein may also normally affect brain monoamine synthesis in humans.
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Proteins (casein) heat treated, frozen and heat retreated show a net decrease of digestibility and utilization as results of synthesis of Maillard compounds, directly related to the total time of heat treatment.
The AA. reports that lysine deficiency in rats results in poor growth, low weight of heart and liver, anemia, hypoproteinemia and low concentration of haemoglobin. Rats fed supplemented lysine diet did not have any pathological condition in comparison with normal rats receiving standard laboratory diet.
Male rats weanling fed 20% gluten diet for 90 days of demonstrate to have about one-third lower level of carnitine per gram of skeletal muscle and heart muscle than the group which received the same diet supplemented with 1% of lysine. The carnitine level of the liver, however, was significantly higher in the unsupplemented versus the lysine supplemented groups.
In the present investigation molecular components associated with the urines from bladder cancer patients and normal individuals are identified. Polyacrylamide gels of urines from bladder cancer, bladder papilloma, and normal individual exhibit clear differences in banding patterns. Urine from bladder cancer patients shows gels with increased quantities of low (less than 100,000) and increased and additional high (less than 100,000) molecular weight proteins when compared to gels with urine from papilloma and normal individuals. In order to localize and identify proteins in the urine from bladder cancer, papilloma, and normal individuals, proteins were separately fractionated on Sephadex G-200 columns and each elution fraction was reacted on Ouchterlony gel diffusion against various specific antisera. The qualitative analysis of proteins in urine from bladder cancer patients is discussed in relation to their molecular weight distribution in the Sephadex G-200 profiles and their possible role in tumor host relationships.
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Smoking is the leading preventable cause of death and the source of numerous problems in the workplace. This study assessed the smoking in health care workers in a general hospital in Central Italy. As part of the health surveillance required by Law No. 626/1994, 2743 employers (40.8% males, 59.2% females; mean age 42.0 ys, SD 9.6 ys) were interviewed. The prevalence of smokers was very high: 36.0% in men and 36.7% in women. When the population was stratified according to occupation, the highest prevalence of smokers was found in ward orderlies (45.2%) and nurses (38.9%) and the lowest in doctors (26.3%). The prevalence of smoking was similar in all occupational divisions--clinical, surgery, diagnostics and administration. This study shows that smoking is more widespread in hospital workers than in an age-matched section of the general population (27.5%). As all health workers should set a positive example in combatting smoking, occupational physicians in charge of health surveillance in hospitals should actively collaborate in smoking dissuasion programmes.