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Biomedical subjects

A Mochizuki

Publications and source records attributed to A Mochizuki.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Two cases of congenital hydronephrosis discovered by renal trauma].

Two cases of congenital hydronephrosis discovered by renal trauma are reported. The first case was a 15-year-old girl. When she was practicing KENDO, her Hakama clung to her legs, and she tumbled. She had emergency operation for abdominal injury. At surgery, no evidence of abdominal injury was detected. Renal trauma was suspected. Right renal angiography revealed hydronephrosis. The second case was a 23-year-old girl, complaining of abdominal pain after stumbling over a block. Intravenous pyelography showed no visualization of the right kidney and CT scan showed an abnormal shadow. Retrograde pyelography and angiography revealed right hydronephrosis. Including our two cases, 47 cases of renal traumata occurring in hydronephrotic kidney in the Japanese literature were reviewed. Thirty five of these cases were males. Many were youths under the age of twenty. Various sports caused many of the renal traumata. 37 of these cases were treated by nephrectomy.

Adolescent↗
PubMed1982

Stimulation of bone resorption by comparatively high dose of zinc in rats.

The changes of femoral calcium and acid phosphatase activity were examined in rats orally administered zinc sulfate (10 mg Zn/100 g body weight) for 3 d. Zinc administration to intact rats produced significant decreases of calcium levels in the serum, and femoral diaphysis and epiphysis, while it caused remarkable remarkable elevation of acid phosphatase activity in the femoral diaphysis and epiphysis. Thyroparathyroidectomy significantly prevented the alterations of the calcium content and the enzyme activity in the femoral diaphysis and epiphysis caused by zinc administration to intact rats. The present results suggest that comparatively high dose of zinc may stimulate bone resorption mainly mediated through the actions of parathyroid hormone, due to maintain calcium homeostasis.

Acid Phosphatase↗
PubMed1982

Stimulatory effect of zinc on bone growth in weanling rats.

The effect of zinc on bone metabolism was investigated in weanling rats orally administered zinc sulfate (0.1, 1.0 and 10 mg Zn/100 g body wt) for 30 d. The administration of zinc produced dose-dependent increases in zinc contents of the femoral diaphysis and epiphysis. The dry weight of the femur was significantly increased by the doses of 0.1 and 1.0 mg Zn/100 g for 3 d, while significant reduction of that was observed by zinc administration for 30 d. Meanwhile, DNA content, calcium content and alkaline phosphatase activity in the femoral diaphysis and epiphysis were significantly increased by the doses of 0.1 and 1.0 mg Zn/100 g for 3 d. However, by the 30 d administration of zinc (0.1, 1.0 and 10 mg/100 g), calcium contents in the femur and serum were markedly decreased. These results suggest that comparatively low dose of zinc may stimulate the bone growth and calcification of weanling rats.

Alkaline Phosphatase↗
PubMed1982

Abnormal response of blood pressure to Master's two-step exercise in patients with essential hypertension.

To clarify the differences in response of blood pressure (BP) in the normotensives and the hypertensives (n = 30, 40 +/- 9 years, 142 +/- 17/91 +/- 14 mmHg, mean +/- SD), the subjects were divided into normotensives (N) (n = 13, 34 +/- 5 years, 114 +/- 6/72 +/- 8 mmHg), prehypertensives (n = 8, 38 +/- 11 years, 125 +/- 6/80 +/- 3 mmHg), borderlines (n = 13, 38 +/- 10 years, 140 +/- 12/85 +/- 9 mmHg), and established hypertensives (n = 9, 43 +/- 6 years, 161 +/- 9/108 +/- 8 mmHg). BP and heart rate were measured in the supine position after a 30-min bed rest and the recovery phase following the double Master's two-step exercise. The rise in systolic BP was significantly greater in the prehypertensives and in the borderlines than in N, but was insignificantly smaller in the established. The rise in diastolic BP was significantly greater in all the groups of the hypertensives than in N. This rise was significantly greater in the borderlines than in the established. A multiple regression correlated significantly between the rise in BP and the resting BP (r = 0.467 in systolic, and r = 0.373 in diastolic). Diastolic BP following exercise increased in the hypertensives, but fell in N. The rise in heart rate was not significantly different between the hypertensives and N. The hyperresponse observed in both prehypertensives and the borderlines was diminished in the established hypertensives. These results suggest that the hyperresponse of BP may play an important role in the development of hypertension in the patients with essential hypertension.

Adult↗
PubMed1981

Noradrenaline and calcium induced tension in aortic strips of normotensive and spontaneously hypertensive rats.

Development of tension in aortic helical strips was studied using the male Kyoto Wistar normotensive (KNR) and age-, sex-matched spontaneously hypertensive rats (SHR) (8 to 10 weeks) to clarify the contractile response of vascular smooth muscle in SHR. In Ca2+-containing solution, noradrenaline-induced tension was smaller in SHR than in KNR. After washing the strips with Ca2+-free EGTA solution, the tension that developed by the addition of Ca2+ was greater in SHR than in KNR. Tension induced by the combination of Ca2+ and noradrenaline was the same between the KNR and SHR. It is assumed that these differences between the KNR and SHR aortic strips may be attributed to the abnormal contractility of the vascular smooth muscle in SHR.

Animals↗
PubMed1981

Hypotensive action of nifedipine (Ca2+-antagonist) and propranolol in acute trials and its long-term therapy of hypertensive coronary heart disease patients.

The hypotensive effect of nifedipine (a Ca2+-antagonist) was studied in acute tests and during the long-term administration of the drug together with propranolol. Nifedipine (10 mg, sublingually) decreased blood pressure from 174/102 to 136/82 mmHg with increase in heart rate and plasma renin activity. The combination of nifedipine (10 mg, sublingually) and propranolol (0.2 mg/Kg body weight, intravenously) decreased blood pressure from 168/104 to 131/86 mmHg with decrease in heart rate and plasma renin activity. Twenty-five hypertensive patients were treated with nifedipine and propranolol (10 mg x 3 to 4/day) together with or without diuretic for long-term. With the combination therapy, blood pressure of Group I (11 hypertensive patients with coronary heart disease) fell from 211/129 to 140/85 mmHg, blood pressure of Group II (9 severe hypertensive patients without coronary heart disease) from 230/137 to 139/84 mmHg, and blood pressure of Group III (5 established hypertension) from 182/107 to 134/83 mmHg. With this treatment regimen, heart rate and plasma renin activity decreased, and abnormal electrocardiographic findings, hypertensive retinopathy, and renal dysfunction were improved. Nifedipine, in combination with propranolol and a diuretic, is considered an effective treatment of hypertension either with or without coronary heart disease.

Antihypertensive Agents↗