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Biomedical subjects

A Manoharan

Publications and source records attributed to A Manoharan.

At least 127 records · Page 7Linked to original sources
PubMed1985

Gold-induced bone marrow aplasia: successful treatment with antithymocyte globulin.

A patient receiving gold treatment for rheumatoid arthritis developed sudden severe pancytopenia secondary to bone marrow aplasia. She required extensive hematological support but was unsuitable for bone marrow transplantation. Although early use of large doses of a chelating agent did not change the hematological parameters, subsequent use of antithymocyte globulin has been associated with substantial hematological improvement.

Anemia, Aplastic↗
PubMed1985

Severe aplastic anaemia following the use of hair dye: report of two cases and review of literature.

We describe two female patients aged 31 and 62 y who developed severe aplastic anaemia following the use of hair dye containing para-toluenediamine. One received a bone marrow transplant but died after developing graft versus host disease and severe opportunistic infection. The second responded to treatment with methylprednisolone, oxymetholone and antithymocyte globulin and 3 y later she has a normal blood count apart from mild thrombocytopenia. In this paper we also review previously described case reports of aplastic anaemia apparently associated with the use of hair dye.

Adult↗
PubMed1984

Low-dose cytarabine in acute myeloid leukaemia.

A series of 20 patients with acute myeloid leukaemia received treatment with cytarabine administered as a single agent at a low dose of 10 mg/m2 every 12 hours for 14-21 days. Complete remission was achieved in six patients (30%), and partial remission in nine patients (45%). These 15 patients survived for periods from two to 15 months, and six patients were still alive at the time of writing the report. A significant reduction in the blood counts, which began seven to 14 days after initiation of the treatment, occurred in all patients who responded to therapy. The time interval from the lowest blood counts to recovery ranged from six to 21 days, and there were no treatment-related deaths. The current status of, and the future prospects for, low-dose cytarabine therapy in patients with acute myeloid leukaemia is discussed.

Adult↗
PubMed1984

Heparin-induced skin reaction.

A case of heparin-induced skin reaction at the sites of subcutaneous injections is reported. The clinical details of 15 previously reported cases are summarized, and the importance of recognizing this complication is discussed.

Blister↗
PubMed1984

Low dose cytosine arabinoside: partial remission of acute myeloid leukaemia without evidence of differentiation induction.

Thirteen patients with acute myeloid leukaemia aged from 19 to 81 were treated with low dose cytosine arabinoside (ARA-C) in a dose of 10-15 mg/m2 twice daily subcutaneously. Three complete remissions were obtained. Partial responses were observed in a further two patients. To analyse the action of low dose ARA-C freshly isolated leukaemic cells and cells from the cloned promyelocytic leukaemia cell line (HL60) were cultured in vitro in the presence of cytosine arabinoside. Minimal evidence of differentiation induction was observed when compared with the cytotoxic effects of the drug. These results suggest that ARA-C does not exert its anti-leukaemic effects by halting proliferation through differentiation induction. Rather, it appeared that the capacity of this agent to kill cells in S-phase produced a progressive depletion of the cycling leukaemic cells. This resulted in a corresponding steady decline in the total leukaemic cell population.

Adult↗
PubMed1984

Chemotherapy resolves symptoms and reverses marrow fibrosis in myelofibrosis.

12 patients with symptomatic chronic myelofibrosis were treated with either busulphan or 6-thioguanine. Therapy was without significant side effects and resulted in a reduction in the size of liver and spleen and an improvement in well-being in all cases. In 7 patients the Hb value rose and the extent of marrow fibrosis was reduced in the 5 patients in whom bone marrow examination was repeated after treatment. Chemotherapy is an effective and safer alternative to splenectomy in patients with myelofibrosis with symptomatic anaemia, symptomatic splenomegaly or constitutional symptoms such as fever, weight loss and night sweats.

Aged↗
PubMed1983

Lymphoma-like presentation of acute monocytic leukaemia.

Four patients in whom a diagnosis of acute monocytic leukaemia (M5) was subsequently made presented with extramedullary disease clinically resembling lymphoma. In all patients histological sections were initially misinterpreted as showing malignant lymphoma or anaplastic carcinoma. The diagnosis of M5 leukaemia was subsequently made on the basis of morphological and cytochemical studies of peripheral blood and bone marrow. The histological diagnosis of the soft tissue lesions of M5 leukaemia (monocytic sarcoma) is difficult, although features such as abundant cytoplasm and the presence of some reniform nuclei are helpful. If there is no peripheral blood or bone marrow involvement and only fixed paraffin-embedded tissues are available, demonstration of lysozyme by an immunoperoxidase technique may confirm the diagnosis but results are not invariably positive. An early diagnosis of M5 leukaemia has therapeutic implications since the disease evolves through a progressive leukaemia phase and systemic therapy is essential.

Adolescent↗