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Biomedical subjects

A M Zemskov

Publications and source records attributed to A M Zemskov.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Immunomodulating therapy of a suppurative infection of the soft tissues].

The initial immunological status in patients with purulent infection of the soft tissues is characterized by T-cell deficiency and relative hyperfunction of the B-immunity. The risk group with Grade 2-3T-cell immune deficiency takes up 44.5-77.5% and is encountered in patients with the B blood group and positive Rh factor in 79.1 +/- 5.2 and 70.8 +/- 4.3% of cases, respectively. Combination of sodium nucleinate and autohemotransfusion with the traditional therapy raises its efficacy. This is attended by correction of immunological disorders in T-cells and phagocytes, facilitates cleansing of the foci and increase of antibiotic sensitivity of the flora, and shortens the term of treatment.

Adjuvants, Immunologic↗
PubMed1991

[The characteristics of the immune status in patients with the Wolff-Parkinson-White syndrome].

A study is presented of 32 patients (18 men, 14 women; age from 16 to 38 years) with WPW syndrome. Immunological investigations revealed characteristic of WPW syndrome phenotypic peculiarities with characteristic changes of the immune status, allowed to evaluate the mechanism of formation of Kent's bundle and to discuss the problem of primary prophylaxis by means of immunoactive agents.

Adolescent↗
PubMed1990

The effect of sodium nucleinate on allergic and immunological reactions.

Experiments on immunized rabbits and guinea pigs indicated that sodium nucleinate (SN) was capable of weakening or entirely eliminating anaphylactic and skin reactions of delayed type hypersensitivity to repeated administration of staphyloanatoxin, APDT vaccine. The findings on patients with the infectious form of bronchial asthma and chronic rheumatism showed that sodium nucleinate attenuated reactions to the subcutaneous administration of staphylococcal and streptococcal allergens. The treatment of patients suffering from infectious-allergic bronchial asthma and rheumatism with SN resulted in the recovery of deficient T cells, T-suppressors, normalization of immunoglobulin concentrations. In children with acute glomerulonephritis sodium nucleinate normalized decreased T-suppressor cells and increased IgG and circulating immune complexes (CIC), resulting in a pronounced remission of disease. The mechanism of desensitization and elimination of CIC by SN has not been explored, however, the parameters of SN-induced immunomodulation are known rather completely. It is suggested that SN brings about accumulation in the cell of cyclic AMP which diminished membrane permeability, activates monoaminooxidase resulting in the degradation of histamine and other biogenic amines, enhances the synthesis of endogenous corticosteroids with their desensitizing properties. All these effects contribute to the elimination of delayed type hypersensitivity. The role of SN in the inhibition of delayed type hypersensitivity remains obscure.

Animals↗
PubMed1990

[The relationship of immunological reactivity to blood groups].

The relationship of blood groups and level of immunological reactivity was studied in 500 patients with different diseases and 246 healthy subjects. Distribution of genetic markers of blood groups in the healthy and patients showed certain characteristic features. It was found that the A (11) blood group in the healthy may be considered a marker of high levels of immunological reactivity resulting in a milder course of diseases in persons of this blood group. It was shown that different pathological states are characterized by variations of immunological reactivity depending on the blood group--on the content of populations and subpopulations of lymphocytes, immunoglobulin of different classes, normal antibodies, grade of immunodeficiency.

ABO Blood-Group System↗
PubMed1990

[Immunocorrective therapy of patients with rheumatoid arthritis].

The clinico-immunological efficacy is shown of including timoptin, levamysol, sodium nucleinate in the complex treatment of patients with rheumatoid arthritis who received glucocorticosteroids. It was found that employment of immunoregulating agents allowed to correct the immunological insufficiency in patients with rheumatoid arthritis, to increase the treatment efficacy.

Adjuvants, Immunologic↗
PubMed1989

[The efficacy of combined immunomodulatory therapy with timoptin and sodium nucleinate in patients with chronic obstructive bronchitis].

Study of the immunologic reactivity of 104 patients with chronic obstructive bronchitis revealed the deficiency of cellular immunity for the most part. The use of timoptin, sodium nucleinate and their combined application raised the clinical efficacy of the treatment of patients with chronic obstructive bronchitis, significantly reduced the concentration of medium-weight molecules in blood serum, and corrected immunity disorders.

Adjuvants, Immunologic↗
PubMed1988

[Increase in the sensitivity of Shigella to antibiotics].

Passages of 10 Shigella strains for 10 times in meat-peptone broth supplemented with sodium nucleinate provided an increase in sensitivity of the cultures to levomycetin for a period of 264 hours. In three strains of S. sonnei, S. flexneri and S. newcastle the authors observed an increase in sensitivity to tetracycline, benzylpenicillin and streptomycin. Some nitrous bases included in sodium nucleinate were also able to increase antibiotic sensitivity in Shigella.

Anti-Bacterial Agents↗
PubMed1986

[Effect of RNA nucleotides on Shigella biology].

Sodium nucleinate and its mononucleotides have been found capable of stimulating the multiplication and virulence of shigellae, as well as their sensitivity to antibiotics, in cultures grown in nutrient media.

Anti-Bacterial Agents↗
PubMed1984

[Comparative effectiveness of immunomodulators in the therapy of rheumatic heart defects].

A total of 166 patients with rheumatic heart diseases were examined. It was shown that the patients had secondary immune deficiency mainly with respect to the T-cells, which could not be eliminated with the routine therapeutic agents. The use of hemodes, decaris or sodium nucleinate in the combined therapy of such patients promoted correction of the immune deficiency and increased the treatment efficacy. Sodium nucleinate proved to be the most active.

Adjuvants, Immunologic↗
PubMed1984

[Correction of secondary immunologic deficiency by using yeast RNA].

In patients with rheumatism, chronic alcoholism and peptic ulcer immune deficiency mainly with respect to T-lymphocytes has been detected. The injection of sodium nucleinate simultaneously with the use of traditional therapeutic remedies induces the correction of secondary immune deficiency for a period of 6-9 months.

Adjuvants, Immunologic↗
PubMed1984

[Principles for assessing and correcting secondary immunological deficiency].

Examination of 923 patients with bronchopulmonary diseases, rheumatic fever, peptic ulcer, hypertension and chronic alcoholism revealed the presence of immune deficiency, particularly as regards the T immunity system. Inclusion of sodium nucleinate into multiple modality treatment promoted correction of immune deficiency and remission of the underlying disease. The patients presenting with peptic ulcer showed the correlation between blood serum RNA and immunological characteristics.

Adjuvants, Immunologic↗