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Biomedical subjects

A M Vasilenko

Publications and source records attributed to A M Vasilenko.

29 records · Page 2Linked to original sources
PubMedDate not supplied

[The opioidergic system in the combined regulation of pain and immunity].

Opioidergic mechanisms are involved in responses to nociceptive and antigenic stimuli at all levels and stages (from peripheral nociceptors to the cerebral cortex and from the precursors of immunocompetent cells to mature effector cells). In most experimental and clinical studies, opioid-mediated analgesia proved to be accompanied by immunosuppression. Opioid receptors of mu, delta, and kappa types are involved in the mechanisms of combined regulation of pain and immunity, with mu and delta receptors suppressing the immune response and kappa receptors enhancing it. By modifying the chemical structure of opioid ligands, it is possible to preserve the analgesic effect and avoid the development of immunosuppression. The opioidergic mechanisms are coupled with nonopioid peptidergic and nonpeptide systems of pain and immunity regulation.

Analgesics, Opioid↗
PubMedDate not supplied

[Prevention by electropuncture of the hypoalgesic effect of fasting].

The influence of electropuncture preventive effect on the dynamics of the human nonciceptive system parameters under conditions of fasting stress was studied in 12 healthy volunteers. The results bear evidence that fasting, just like other types of stress, is attended by the development of hypoalgesia. Diminished appreciation of pain is determined by parameters characterizing the effective and sensory components of pain sense. Electropuncture conducted during fasting inhibits the development of pain sense disorders induced by fasting stress, reduces some of the emotional reactions, and has no unfavourable side-effects. The results of the study suggest that electropuncture can be applied as a stress-limiting measure in fasting.

Acupuncture Therapy↗
PubMedDate not supplied

[Prevention and correction of stress-induced immunodeficiency by atrial electroacupuncture].

Secondary immunodeficiency characterized by a sharp decrease in the number of antibody-forming cells in the lymph organs developed in mice under conditions of an immunosuppressive effect of swim stress and hypobaric hypoxia. Auricular electroacupuncture (AEAP) preceding swim stress blocks its immunosuppressive effect completely. AEAP possesses a high preventive action and also produces a marked corrective effect in development of stress-induced immunodeficiency. For instance, AEAP applied in the productive phase of the immune response restores effectively immunocompetence of the body subjected to hypobaric stress. In applying AEAP, the coefficients of antibody-production stimulation in the cells of the lymph nodes, calculated in relation to the hypoxic control, are 3.5-4.0, which do not yield to the values recorded with the use of the most effective pharmacological immunomodulators. AEAP may be considered a promising measure for the prevention and correction of immunodeficiency caused by stress.

Acupuncture Therapy↗
PubMedDate not supplied

[Electroacupuncture in the prevention of the immunosuppressive action of surgical stress].

Immunological indexes have been studied in 22 patients during planned herniotomy and in 52 healthy donors. The study group comprised 12 patients operated on under local anesthesia in combination with electroacupuncture analgesia (EAPA). Premedication was not performed, narcotic analgesics, neuroleptics and antihistamine agents were also excluded. The control group consisted of 10 patients operated on under local anesthesia after premedication with promedol. Analgesia in the postoperative period was performed using chEHC-2 apparatus in the study group and using narcotic analgesics in the control group. Most indexes characterizing the initial immune status were decreased in both groups, as compared to those observed in healthy donors. A pronounced immunomodulating effect of EAPA on immunoregulatory subpopulations of T-lymphocyte helpers/inducers (Tmu) and suppressors/killers (T gamma) was noted. EAPA did not affect optimal relations between immunoregulatory subpopulations, which was confirmed by immunoregulatory index value, and prevented inhibition of functional lymphocyte activity in blasttransformation reaction to mitogen (PHA).

Electroacupuncture↗
PubMedDate not supplied

[Maximum oxygen consumption as a test of human resistance to hypoxia, hyper- and hypothermia].

Study of experimental results shows that physical work capacity if an adequate indicator of human tolerance to adverse environmental effects. Maximum oxygen uptake, being a measure of physical work capacity, can be used as a prognostic indicator of human tolerance and adaptive capability in a hypoxic, high or low ambient temperature environment. Increase in maximum oxygen uptake under the influence of training or adaptation to hypoxia is accompanied by increase in heat and cold resistance.

Acclimatization↗