Wart-like porokeratosis of Mibelli.
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Biomedical subjects
Publications and source records attributed to A M Eng.
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A wide variety of sweat gland tumors occur in the eyelids. We used light and electron microscopy to investigate an eccrine acrospiroma showing areas of oncocytic, apocrine and sebaceous differentiation. To our knowledge this is the first report of an oncocytic lesion arising from an eccrine sweat gland, and only the second report of such a lesion arising from the skin. Furthermore, apocrine and sebaceous differentiation are atypical in lesions originating from sweat glands. The wide spectrum of differentiation in this adenoma lends further support to the concept of pluripotentiality of the adnexal glandular epithelia.
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By fine needle aspiration biopsy, 58 cases of cutaneous metastases were clinically and cytologically diagnosed at the Hines Veterans Administration Hospital from January 1987 to December 1990. Immunologic and electron microscopic studies affirmed the diagnosis and in some instances defined the primary neoplasm. The age of the patients ranged from 54 to 83 years (mean, 65). All were men. Two groups of patients emerged: group 1, 37 patients with known cancer, constituted the majority (64%). Group 2 consisted of 21 patients with cutaneous metastasis as the presenting sign (36%). Our patient survival times, a few weeks to 16 months (average, 4 months) are consistent with previous reports.