Search PubMed⌕ Search

Biomedical subjects

A M Eng

Publications and source records attributed to A M Eng.

At least 37 records · Page 2Linked to original sources
PubMed1983

Solitary small active junctional nevi in juvenile patients.

Solitary small very dark and papular pigmented nevi, less than 4 mm, are seen commonly in the second decade of life and have a distinctive histologic pattern. Microscopically these lesions show abundant intraepidermal melanin, included within the keratin layer, and proliferating single melanocytes or nevus cell nests. Prominent nucleoli in the melanocytic cells, occasional mitoses, and the invariable presence of moderate numbers of dermal melanophages and lymphocytes indicated the activity of the pathologic process. The benignity of the lesions in nine patients is supported by a benign course over a one- to three-year evaluation period after limited excisional biopsy procedures. The clinical and pathologic evidence of activity in these nevi suggests yet another possible precursor of malignant melanoma. The B-K mole syndrome and the dysplastic nevi syndrome differ from these cases both clinically and histologically.

Adolescent↗
PubMed1981

Peforating calcinosis cutis presenting as milia.

Two children with unusual milia-like lesions on the pubic and groin area were found to have idiopathic perforating calcinosis cutis. The inconspicuous clinical appearance may escape detection unless a biopsy is performed.

Calcinosis↗
PubMed1981

Clinicopathologic correlations in Alibert-type mycosis fungoides.

Five cases of mycosis fungoides of the Alibert type were studied by taking multiple biopsy specimens at different stages of the disease. Large hyperchromatic, slightly irregular mononuclear cells are the most frequent cells. Ultrastructurally, the cells were only slightly convoluted, had prominent heterochromatin banding at the nuclear membrane, and unremarkable cytoplasmic organelles. Highly convoluted cerebriform nucleated cells were few. Large regular vesicular histiocytes were prominent in the early stages. Ultrastructurally, the cells showed evenly distributed euchromatin. Epidermotrophism was equally as important as Pautrier's abscess as a hallmark of the disease. Stereologic techniques comparing the infiltrate with regard to size and convolution of cells in all stages of mycosis fungoides with infiltrates seen in a variety of benign dermatoses showed no statistically significant differences.

Aged↗
PubMed1980

Giant congenital neuroid melanocytic nevus.

A patient with a variety of nevus cell nevi, a congenital giant melanocytic nevus, abnormal facies, vascular anomaly of the leg, and mental retardation was examined. The patient also had neuroid elements within the giant nevus that led to the consideration of neurofibromatosis. Because neurofibromatosis is a genetically determined condition with tissue different from the neuroid elements seen in giant nevi, the two conditions are considered to be different entities. Malignant transformation of congenital giant pigmented nevi occurs, although the incidence of such transformation remains a subject of controversy.

Abnormalities, Multiple↗
PubMed1979

Harlequin fetus.

Explore the source record for details and available documents.

Abnormalities, Multiple↗
PubMed1979

Giant condyloma acuminatum.

The subtle histologic differences between condyloma acuminatum and giant condyloma acuminatum are presented in the following report.

Condylomata Acuminata↗
PubMed1979

Erythematous generalized granuloma annulare.

Two elderly patients had a distinctive generalized, erythematous form of granuloma annulare. The granulomatous changes were shown to be located superficially in the dermis. One patient had diabetes mellitus and carcinoma of the breast. Both patients had pulmonary emphysema.

Aged↗
PubMed1977

Cytologic features of hyperplastic epidermis.

The cytologic features of hyperplastic epidermis in common lesions such as verruca, seborrheic keratosis, condyloma accuminatum, fibroepithelial polyp, corn, radiodermatitis, prurigo nodularis, epidermal nevus, dermatofibroma, tricholemmona, inverted follicular keratosis and pseudoepitheliomatous hyperplasia were studied. Common, as well as distinguishing cytologic points are recognized.

Cell Division↗
PubMed1976

Familial generalized dyschromic amyloidosis cutis.

A generalized form of primary cutaneous amyloidosis was found in two siblings when microscopic examination was carried out on areas of scattered hypopigmentation. Multiple biopsies from different sites of the skin suggested that the pigmentary disorder was probably a process independent of the amyloidosis. One of the siblings died of interstitial pulmonary fibrosis, congenital pulmonary stenosis and diabetes mellitus. Post mortem examination of the lungs showed the presence of few amyloid deposits in the diffusely fibrotic tissue, suggesting that these were secondary to the chronic pulmonary disease. Because of the absence of amyloid involvement in parenchymatous organs and the absence of cutaneous signs of systemic amyloidosis as macroglosia or petechiae, this case suggests that primary cutaneous amyloidosis is distinctly different from the cutaneous manifestation of primary systemic amyloidosis.

Adult↗
PubMed1975

Clinical pathologic observations in pseudoxanthoma elasticum.

Skin biopsy material obtained from 2 patients with pseudoxanthoma elasticum associated with congenital hyperphosphatasia was compared with skin biopsy material obtained from 3 patients with pseudoxanthoma elasticum unassociated with any other disease. Clinically normal skin showed calcification of normal-appearing elastin as the initial change in pseudoxanthoma elasticum. Elastin fibers become more ravelled as the disease progresses. A previously unreported early transient calcification of collagen was demonstrated. Other abnormal collagen forms may also be present. The Von Kossa stain appears to be the stain of choice for identifying these earliest histologic changes.

Adolescent↗
PubMed1975

Generalized eruptive porokeratosis of Mibelli with associated psoriasis.

A case of eruptive porokeratosis of Mibelli with diverse morphologic features, including circinate macular, circinate plaque and verrucous varieties is presented. No matter how variable the clinical presentation may be, the histologic hallmark of porokeratosis, the cornoid lamellae, is always present. The cornoid lamellae vary in height in relation to how prominent the thready ridge of the clinical lesion appears. Our patient also had psoriasis which initially masked the porokeratotic lesions both clinically and histologically. Awareness of the various clinical expressions of porokeratosis of Mibelli would 1) make unnecessary the segregation of certain forms of porokeratosis into separate entities, and 2) help in the recognition of less classical forms of porokeratosis.

Foot Dermatoses↗