[Familial aminoaciduria with muscular hypotonia and dwarfism].
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Biomedical subjects
Publications and source records attributed to A Lowenthal.
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Due to methanol intoxication, a 38-year-old male developed permanent parkinsonism with visual impairment. Brain computerized tomography (CT) and magnetic resonance imaging (MRI) revealed cystic resorption of the putamen. An alteration of the central noradrenergic activity and the opioid system can be assumed because of increased dopamine beta-hydroxylase (D beta H) activity and decreased methionine-enkephalin (Met-Enk) levels in the cerebrospinal fluid (CSF).
The European Stroke Prevention Study showed: 1. That the association Persantin-Aspirin reduces stroke and vascular death risks with 36,5% in a population of 2500 patients. Risk reduction persisted during the two years follow-up and was the same for men and women. 2. That this reduction is higher than the reduction obtained in all other studies with anti-aggregation prevention. 3. That studies with less than 600 patients cannot lead to significant differences.
Evaluation of the first 365 neurological patients examined with a 0.15 tesla resistive nuclear magnetic resonance (MRI) installation is reported. Plus points of MRI compared with the diagnostic possibilities of computed tomography are presented.
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In this study, the brain specific proteins alpha-albumin and glial fibrillary acidic protein (GFA) are compared by several biochemical and immunological methods. It is concluded that alpha-albumin and GFA are immunologically identical and biochemically narrowly related. The existence of two forms of this protein, a water soluble and a water insoluble, under physiological conditions is discussed by comparing the results of quantitative determinations and histoimmunological localizations.