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Biomedical subjects

A Leriche

Publications and source records attributed to A Leriche.

44 records · Page 3Linked to original sources
PubMed1976

Urodynamic assessment of stress incontinence and its therapeutic implications.

Urethral fibrosis and sphincter incompetence commonly are associated in the genesis of stress incontinence. Other factors are often associated, such as bladder hyperactivity and increased demand on the sphincter mechanism created by contracted or large atonic bladder or polyuria. The frequent association of several factors and the limited information given by the classical methods suggest a need for the routine use of objective urodynamic studies in the assessment of stress incontinence. A more conservative, better oriented, therapeutic approach may result from this concept.

Female↗
PubMedDate not supplied

Basic fibroblast growth factor and keratinocyte growth factor over-expression in benign prostatic hyperplasia.

The prostate growth is under the indirect control of androgens through the medium of many growth factors. The fibroblast growth factors (FGFs) seem to play an important part in stimulating the development of this organ. In this work, the expression of two FGFs: bFGF (or FGF2) and KGF (or FGF7), was studied in RT-PCR and semi-quantified in densitometry. Both genes expression was increased in BPH in comparison with normal prostates. A two to three times and a 1.5 to four times over-expressions were observed for bFGF and KGF, respectively. An over-expression of these growth factors could lead to a cell multiplication resulting in a pathological development of the prostate size. Moreover, bFGF and KGF act in parallel in the prostate, one stimulating the prostatic stroma and the other one stimulating the epithelium. These two growth factors could participate in the increase of the two tissues constituting the prostate.

Aged↗
PubMedDate not supplied

[Hyperuricosuria and urinary lithiasis in paraplegic patients (author's transl)].

One hundred and thirteen urinary stones fron spinal cord injured patients contain urates in 65,5% of cases. In a prospective study of 21 paraplegic patients, an early increase of uricosuria was found as well as a late and moderate elevation of uricemia. The origin of these changes of the metabolism of uric acid is discussed. Therapeutic consequences from these results are studied.

Adolescent↗
PubMedDate not supplied

[Structure and expression of thyroglobulin gene].

Thyroglobulin is composed of two 300000 dalton polypeptide chains, translated from an 8000 base mRNA. Preparation of a full length cDNA and its cloning in E. coli have lead to the demonstration that the polypeptides of thyroglobulin protomers were identical. Used as molecular probes, the cloned cDNA allowed the isolation of a fragment of thyroglobulin gene. Electron microscopic studies have demonstrated that this gene contains more than 90% intronic material separating small size exons (less than 200 bp). Sequencing of bovine thyroglobulin structural gene is in progress. Preliminary results show evidence for the existence of repetitive segments. Availability of cloned DNA complementary to bovine and human thyroglobulin mRNA allows the study of genetic defects of thyroglobulin gene expression in the human and in various animal models.

Animals↗