Biomedical subjects
Publications and source records attributed to A Ledo.
A case of epidermolysis bullosa acquisita (EBA) with negative direct immunofluorescence and multiple myeloma is reported. Epidermolysis bullosa acquisita has been associated with several systemic diseases, but only three cases diagnosed of EBA have been associated with multiple myeloma in the literature.
A female patient with neurofibromatosis (involving the segmental arrangement of neurofibromata) and contralateral partial lentiginosis is described. This case is an unusual presentation of segmental neurofibromatosis.
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The neutrophilic dermatosis are a group of cutaneous diseases that share similar clinical and histopathologic features. They frequently occur in association with other diseases, particularly idiopathic inflammatory bowel disease. We present herein three cases of neutrophilic dermatosis and inflammatory bowel disease. We emphasize the atypical cutaneous findings and we discuss their nosologic situation.
This case report describes the simultaneous occurrence of antiphospholipid antibody syndrome in a patient with cutaneous T-cell lymphoma. An abnormal T cell-B cell cooperation is postulated to explain this unusual association. To the best of our knowledge, no similar cases have been reported previously.
This case report describes the simultaneous occurrence of pyoderma gangrenosum and subcorneal pustular dermatosis. They are both neutrophilic dermatoses that have been described associated in several instances. The association of pyoderma gangrenosum and other cutaneous diseases is also reviewed.
A 26-year-old man, with a personal history of drug abuse and positive serology for HIV, had Reiter's syndrome for six years. He experienced progressive worsening of his cutaneous lesions after initiation of indomethacin therapy. The skin lesions were almost completely resolved after the discontinuance of the drug and its reintroduction resulted in a similar deterioration. To our knowledge, indomethacin has not been reported to aggravate Reiter's syndrome. This case study documents anti-inflammatory drugs as possible causal factors for triggering Reiter's syndrome. Possible implicated mechanisms are also discussed.
Pyoderma gangrenosum is a distinctive, uncommon, ulcerative condition with an associated systemic disease in most cases. The causative mechanism of this disease is still unknown. In this article, we review the pathogenesis of pyoderma gangrenosum, its clinicopathologic picture and the currently available therapeutic alternatives. Associations with systemic disease are also reviewed.
We report herein a rare case of metastatic Crohn's disease involving the penile and scrotal skin in a 56-year old man. We review the literature about this rare entity and describe its clinicopathological characteristics.
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A randomized double-blind parallel trial comparing acitretin and etretinate was performed in 20 patients with severe psoriasis during a treatment period of 12 weeks. The initial dose was 30 mg/day for 4 weeks, and the mean dose at the end of the study was slightly lower in the acitretin group when compared to the etretinate group (30.7 mg/day and 33.4 mg/day, respectively). Follow-up examinations were carried out every 2 weeks, and the efficacy of treatment was evaluated by using the PASI score. Percentage improvement in the PASI score was 50% at week 10 in both groups, and the difference between them at week 12 was insignificant. Both quantitatively and qualitatively, acitretin and etretinate do not significantly differ.
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Two cases of pre-Sézary erythroderma of several years of evolution that evolved into Sézary syndrome are presented. The role of persistent antigenic stimulation in the development of T-cell lymphoproliferative disease in discussed. We also review the different therapeutic approach to Sézary syndrome.
Three cases of primary cutaneous neuroendocrine carcinoma involving the face are reported. In the first patient the tumor developed in the scar of a previously excised basal cell carcinoma of the nose, recurred locally, and metastasized to a regional lymph node 2 1/2 years after initial treatment. In the second and third patients the tumors were located on the forehead and were removed with a wide excision. In the second patient the tumor metastasized to regional lymph nodes 1 month after treatment. Light microscopic examination in all patients showed an undifferentiated, small cell, dermal tumor with prominent epidermotropism, forming Pautrier-like microabscesses. Immunohistochemical staining for neuron-specific enolase was positive, and ultrastructural examination revealed numerous cytoplasmic neurosecretory granules and paranuclear aggregates of intermediate-sized filaments. The literature concerning epidermal involvement by primary neuroendocrine carcinoma of the skin is reviewed; the relation with basal cell carcinoma and treatment are discussed.
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Explore the source record for details and available documents.