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Biomedical subjects

A Lechi

Publications and source records attributed to A Lechi.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Vasodilating properties of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on rat aortic rings.

The effects of nitroflurbiprofen (NFP), a new non-steroidal anti-inflammatory drug containing a nitroxybutyl moiety, on rat aortic rings were compared with those of flurbiprofen (FP) and glyceryl trinitrate (GTN). NFP and GTN relaxed, in a dose-dependent manner, either intact or rubbed aortic rings precontracted with epinephrine. Pretreatment with FP did not influence the relaxant activity of NFP in both endothelium-intact and -denuded arteries. In unrubbed preparations, FP did not affect contraction induced by epinephrine, while in rubbed ones a moderate relaxation was observed. Methylene blue and oxyhaemoglobin completely reversed the vasodilating effect of NFP in both rubbed and unrubbed preparations. Moreover, the addition of cysteine 5 mmol l-1 at the end of the cumulative application of NFP resulted in a further relaxation of aortic rings. These results indicate that NFP possesses vasodilatory activity which appears to be dependent on the release of nitric oxide or nitric oxide derivatives.

Animals↗
PubMedDate not supplied

Effect of indomethacin on urinary kallikrein excretion in Bartter's syndrome of the adult.

An elevated urinary kallikrein excretion was found in 3 out of 4 adult patients with Bartter's syndrome. After prostaglandin synthesis inhibition by indomethacin, serum potassium levels rose, plasma renin activity and urinary aldosterone excretion decreased. Urinary kallikrein excretion was reduced to within normal range in all patients. The fall of urinary kallikrein excretion after indomethacin may be partly due to plasma potassium and aldosterone variations, but more likely it is dependent on the reduced prostaglandin synthesis. These results support the hypothesis that renal prostaglandins activate renal kallikrein-kinin system, hence inducing an increase of renal blood flow, diuresis and natriuresis.

Adult↗
PubMedDate not supplied

Adult metachromatic leucodystrophy: clinicopathological report of two familial cases with slow course.

Two cases of adult metachromatic leucodystrophy in one family are reported. The main clinical features in both were predominantly psychiatric with alcoholism and an extremely long duration of the illness. Neuropathological examination revealed a similar distribution of the lesions in both, and scanty metachromatic accumulation in the CNS and not at all elsewhere. The great variability of the lengths of the courses is stressed. The duration in no way seems to be linked to the age of onset, except in the typical infantile form. The authors argue that different lengths of history correlate with distinct neuropathological findings, and may possibly be related to qualitative differences in the involved enzyme disturbance. Therefore, the authors suggest that the classification based on the age of onset be enlarged with a further one distinguishing between 'rapid' and 'slow' course types.

Aged↗