Biomedical subjects

A Lanas

Publications and source records attributed to A Lanas.

93 records · Page 6Linked to original sources

PubMedDate not supplied

Effects of nitrate and prophylactic aspirin on upper gastrointestinal bleeding: a retrospective case-control study.

Experimental studies suggest that nitric-oxide releasing drugs reduce gastroduodenal damage induced by non-steroidal anti-inflammatory drugs, but it is not known whether these agents have this effect in humans. The aim of the present study was to evaluate the risk of upper gastrointestinal bleeding in patients who receive aspirin and nitrates for vascular occlusive diseases. This was a retrospective case-control study of 736 consecutive patients admitted with upper gastrointestinal bleeding, compared with 1472 age- and sex-matched hospital controls. Chronic low-dose aspirin regimens had been used by 12.6% of cases and 5.7% of controls, nitrates by 4.8% and 5.8%, and combined nitrates and low-dose aspirin by 2.7% and 1.9%, respectively. Logistic regression analysis identified low-dose aspirin use as an independent risk factor for gastrointestinal bleeding, whereas nitrate use was found to be a protective factor. The combination of both nitrate and low-dose aspirin was not associated with an increased risk of bleeding.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMedDate not supplied

[Recurrent digestive hemorrhage as a complication of an intraduodenal diverticulum].

Intraluminal duodenal diverticulum (IDD) is a rare congenital anomaly, which usually causes symptoms in adulthood. We report a 39-year-old woman, who presented several episodes of upper gastrointestinal bleeding and who was successfully treated with surgery. The clinical presentation, diagnosis and treatment of the 56 cases published in the English and Spanish literature from 1975 to 1998 are reviewed.

Adult↗

PubMedDate not supplied

NSAID use and abuse in gastroenterology: refractory peptic ulcers.

With current antiulcer therapies to eliminate H. pylori infection, non-steroidal antiinflammatory drug use is the main factor involved in resistant peptic ulcers which must be defined as those ulcers that do not heal after 6 (duodenal ulcers) or 8 (gastric ulcers) weeks of treatment with proton pump inhibitors, despite H. pylori eradication. NSAID use (especially aspirin abuse) in patients with resistant ulcers is often surreptitious. Ulcers tend to complicate with stenosis and bleeding, commonly change site, are multicentric and have poorly defined margins. These patients should never undergo surgery unless they develop uncontrolled complications, since ulcer recurrence is the rule. Analgesic abuse and personality disorders might present in some of these patients. Refractory ulcers with no evidence of NSAID use and no evidence of H. pylori infection are rare but not exceptional. Smoking and genetic background seem important factors in patients with this type of ulcers. Idiopathic basal gastric acid hypersecretion might be important in a few patients, but the Zollinguer-Ellison syndrome must be ruled out.

Anti-Inflammatory Agents, Non-Steroidal↗