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Biomedical subjects

A Lanas

Publications and source records attributed to A Lanas.

At least 91 records · Page 5Linked to original sources
PubMed1989

[Effectiveness of emergency endoscopic sclerosis in the control of digestive hemorrhage caused by gastroduodenal ulcer].

An investigation was made of the effect of emergency endoscopic sclerotherapy on the evaluation of digestive hemorrhage (HDA) secondary to gastroduodenal ulcer disease in two consecutive groups of patients. The control group included 92 patients and the sclerotherapy group contained 63. Both groups had the same management and basic treatment of hemodynamic stabilization, anti-H2 agents and alkaline . The sclerotherapy group also received a local injection of 1/10,000 (5-12 ml) adrenaline and 1% polydocanol (5-12 ml) if direct signs of hemorrhage (active bleeding, red clot, visible vessel) were seen at the time of early endoscopy. Surgery was indicated in the presence of persistent, recurrent or massive digestive hemorrhage. Thirty-two percent of the control group and 34% of the sclerosis group presented direct signs of hemorrhage at the time of endoscopy. Both groups were homogeneous with respect to sex distribution, NSAID intake, hemoglobin, presence of shock and etiology (33.3% and 36.3%, respectively, had duodenal ulcer). The average age was significantly higher in the control group than in the sclerotherapy group. Neither the presence of any endoscopic sign nor etiology contributed to the evolution of digestive bleeding. It is concluded that emergency endoscopic sclerotherapy with injection of adrenaline and polydocanol has a clearly favorable effect on the evolution of bleeding secondary to gastrointestinal ulcer disease evidencing direct signs on endoscopy.

Acute Disease↗
PubMed1989

[Prevalence of peptic ulcer in smokers and non-smokers in Aragon].

The present study has attempted to determine the prevalence of peptic ulcer (UP) in smokers and nonsmokers in the geographic region of Aragon (Spain) using a sample of 10,000 subjects, 1,897 with ulcer, 1,708 of them diagnosed by endoscopy. The prevalence of smokers is 42.4% (63% of males and 14% of females). The prevalence of peptic ulcer in smokers (26.87%) is double that of nonsmokers (13.38%) (p less than 0.05). In males, all of the locations (duodenal, duodenal + gastric and gastric) are more common among smokers than among nonsmokers. These differences do not exist in women, gastric ulcer being more common among nonsmokers. Complications were more frequent among smokers with ulcer (60%) than among nonsmokers with ulcer (40%).

Duodenal Ulcer↗
PubMed1988

Role of beta-adrenoreceptors in the inhibition of gastric acid secretion after duodenal acidification in dogs.

The role of the adrenergic system in the duodenal mechanisms that inhibit gastric acid secretion (GAS) after duodenal acidification (DA) was studied. In 12 mongrel dogs, with gastric and duodenal fistulas, six experiments were carried out evaluating pentagastrin-stimulated GAS and serum secretin levels: DA (HCl 2 ml/min) for 1 h (group A); DA (HCl 2 ml/min) for 1 h plus propranolol (group B); DA (HCl 2 ml/min) for 1 h plus phentolamine (group C); duodenal instillation of saline (2 ml/min) for 1 h (group D); (duodenal instillation of saline (2 ml/min) for 1 h plus propranolol (group E), and duodenal instillation of saline (2 ml/min) for 1 h plus phentolamine (group F). Significantly (p less than 0.05) high percentages of inhibition of GAS (49-70.5%) paralleled with increases of serum secretin levels (48.4-84%) were noted in group A and C experiments. However, DA did not inhibit GAS nor did it increase the levels of secretin in group B and D-F experiments. It is concluded that the inhibition of GAS after DA is controlled, at least in part, by the action of the beta-adrenoreceptors.

Adrenergic alpha-Antagonists↗
PubMed1987

[Effect of vagotomy on the duodenal mechanisms regulating gastric secretion].

Gastric acid secretion, gastrin and secretin serum levels after duodenal acidification were studied in 6 dogs, before and after a troncular vagotomy was performed in each one. After duodenal acidification in normal dogs, a 45.2% inhibition of gastric acid secretion with parallel 55-84% increases in the serum secretin levels, without changes in the serum gastrin levels, was noted. When a troncular vagotomy was performed in the same dogs, duodenal acidification produced a 20% (non significant) inhibition of gastric acid secretion with parallel 34-72% increases in the serum secretin levels and without changes in the serum gastrin levels. It is concluded that vagus nerve is necessary to assess a physiological inhibition of gastric secretion after duodenal acidification and it is suggested that humoral and nervous factors are implicated and coexist in these mechanisms.

Animals↗
PubMed1985

Physiopathological heterogeneity of the duodenal mechanisms that inhibit gastric acid secretion in duodenal ulcer patients.

The effect of duodenal acidification on pentagastrin-stimulated gastric acid secretion was studied in 43 duodenal ulcer patients and in 17 normal controls. Three types of responses were observed: group A, no inhibition of gastric acid secretion occurred in 17 (40%) ulcer patients and in three (18%) controls (p less than 0.05); group B, inhibition of gastric acidity occurred in seven (16%) ulcer patients and in 12 (71%) controls (p less than 0.05), and group C, retarded gastric acid inhibition occurred in 19 (44%) duodenal ulcer patients and in 2 (12%) controls (p less than 0.05). Secretin levels did not increase after duodenal acidification, the higher percentages of failure being observed in groups A and C (p less than 0.05). The pH of the duodenal aspirate was 4.9 +/- 2 and 7.7 +/- 1.4 in ulcer patients and controls, respectively (p less than 0.05), with the low levels being detected in groups A and C (4.7 +/- 2 and 5.3 +/- 2.1) compared to group B (7.3 +/- 1.7; p less than 0.05). The results show that responses of duodenal ulcer patients to duodenal acidification are heterogeneous, and that failure of gastric secretion inhibition and defective intraduodenal acid neutralization are related.

Adult↗
PubMed1985

[Role of gastrin in duodenal mechanisms of inhibition of gastric secretion in the dog and man].

Gastrin serum levels after acidification of the second portion of the duodenum were studied, in dogs and humans, while simultaneously measuring secretin levels and gastric acid secretion. After duodenal acidification in dogs, a 50% inhibition of gastric acid secretion with parallel 100% increases in the serum secretin levels was noted whereas gastrin serum levels did not change (after duodenal acidification). In humans, a 25% inhibition of gastric acid secretion with parallel 50% (not significative) increases in the secretin serum levels was noted. In the entire group gastrin levels did not change, but in 35.2% of the subjects a little increment without statistical significance was noted. It is concluded that the inhibition mechanism of gastric acid secretion after duodenal acidification is more important in dog than in man, and that, probably, gastrin does not play an important role in this mechanism.

Adult↗