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Biomedical subjects

A Koide

Publications and source records attributed to A Koide.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Studies on the mechanism of defective natural killer cytotoxicity in patients with multiple myeloma].

Multiple myeloma patients in the advanced or remission stage exhibit significantly lower natural killer (NK) activity than normal subjects. Single-cell assay showed that the number of active NK cells was the same for all patients. The maximum killing potential (Vmax) in advanced patients was lower than in normal subjects. These results suggest that defective NK activity in advanced patients is due to a reduced recycling capacity.

Adult↗
PubMed1983

Modification of amino groups in porcine pancreatic elastase with polyethylene glycol in relation to binding ability towards anti-serum and to enzymic activity.

Porcine pancreatic elastase was modified by activated polyethylene glycol (2-0-methoxy-polyethyleneglycol-4, 6-dichloro-s-triazine) with molecular weight of 5000. The modification of elastase in which three amino groups out of the total four amino groups in the molecular gave rise to a complete loss of the binding ability towards anti-elastase serum from rabbit. The modified enzyme showed 35% of the original enzymic activity towards succinyl-L-alanyl-L-alanyl-L-alanine-p-nitroanilide and 17% towards casein. The heat-denatured collagen was also digested by the modified elastase, but the enzymic activity towards the elastin substrate was completely lost. The inhibition of the modified elastase activity by alpha 2-macroglobulin was found to be lesser than that of non-modified elastase.

Animals↗