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Biomedical subjects

A Klimek

Publications and source records attributed to A Klimek.

At least 19 recordsLinked to original sources
PubMed1999

[Night headache: report of 2 cases].

The pathogenesis of hypnic headache is still unknown. Some authors supposed that the genesis of hypnic disorder is a decrease of melatonin secretion. It is a rare, moderately severe headache that occurs in middle-aged or elderly patients and affects both sexes. It appears exclusively during sleep and often with alarm clock regularity. The attack lasts from two to 6 hours, it may be unilateral or diffuse, pulsating or boring, without autonomic system features. Case 1. A 49 year old man reported the history of two week nocturnal headache that awakened him every night from sleep. The headache lasted two hours. There were no autonomic system features. Case 2. A 52 year old man suffered from nocturnal headaches for 6 weeks. The pain occurred between 2 and 5 almost every night and woke the patient. He suffered from diabetes mellitus too. Both patients were treated with flunarizine with good results.

Circadian Rhythm↗
PubMed1996

The immunohistochemistry and ultrastructure of ganglioglioma with chromosomal alterations: a case report.

Ganglioglioma, together with its counterparts-ganglioneuroma and gangliocytoma are relatively uncommon neoplasms of the brain composed of neoplastic neurons (ganglion and ganglioid cells) and glial cells. We report here a case of ganglioglioma studied by electron microscopy. The case was further characterized by peculiar chromosomal alterations, 46,XX[6]/43,XX[1], der(1)t(1;5)(q21;q12), der(8;13)(q10;q10),-9,i(10)(q10). Routine light microscopy revealed mixed neuro-glial tumor composed of pilocytic astrocytes with abundant Rosenthal fibers and relatively numerous ganglion cells. The latter were immunoreactive with antibodies (Abs) against synaptophysin and neurofilament protein (NFP). Anti-NFP Abs also immunostained numerous distorted axons embedded in the tumor mass. Some of these showed bullous swellings and thus were analogous to dystrophic neurites or spheroids. Ganglion cells were characterized by abundant intracytoplasmic dense-core vesicles, absence of intermediate filaments and numerous microtubules. Occasionally a close apposition of ganglion cells and Rosenthal fibers were seen. Dense-cored vesicles were pleomorphic and ranged in diameter from small synaptic vesicles to large lysosome-like neurosecretory granules. The former occasionally formed characteristic dumbbell shapes. Neoplastic astrocytes were identical to those of other glial tumors of astrocytic lineage; numerous Rosenthal fibers were frequently seen.

Brain Neoplasms↗
PubMed1995

Creutzfeldt-Jakob disease: ultrastructural study of brain biopsy: unusual interaction between astrocytes and oligo- and microglia.

We report a case of Creutzfeldt-Jakob (CJD) disease in a 72-year-old man without characteristic EEG alterations. Unusually abundant pleomorphic PrP-immunopositive amyloid plaques were found in the cerebellum. Despite of this similarity with Gerstmann-Străussler-Scheinker (GSS) disease the case cannot be classified as GSS lacking classical GSS 102 PRNP gene mutation. The ultrastructural findings were similar to those described previously for CJD. The close contact of reactive astrocytes with both oligodendroglia and microglia in this case suggests their possible functional interaction.

Aged↗
PubMed1988

Effect of bromocriptine and metoclopramide on serum prolactin levels in patients with amyotrophic lateral sclerosis.

Secretion of prolactin in nine patients with amyotrophic lateral sclerosis and in seven healthy men was investigated with the use of metoclopramide stimulation and bromocriptine inhibition tests. Blood serum prolactin concentration was determined in the basal state and 30, 60 and 120 minutes after oral administration of 10 mg metoclopramide or 2.5 mg bromocriptine. A period of 3 days intervened between testing each drug in the same individual. It was shown that basal prolactin levels in amyotrophic lateral sclerosis patients and the controls did not differ significantly, whereas in the metoclopramide stimulation test seven amyotrophic lateral sclerosis patients showed a very exaggerated response. The mean value of maximal prolactin increment was 1609.90% (SD 456) in comparison with the control group 638.3% (SD 89.7) (p less than 0.01). In the bromocriptine inhibition test the mean value of maximal prolactin percentage decrement was 50.4% (SD 6.1) in amyotrophic lateral sclerosis and 66.5% (SD 5.3) in the controls and this difference was statistically insignificant. These data suggest that exaggerated prolactin response to metoclopramide in amyotrophic lateral sclerosis may be a result of a decreased activity of central dopaminergic neurons.

Aged↗
PubMed1987

Cluster-tic syndrome.

A case of cluster-tic syndrome is presented. A 51-year-old man developed pain attacks corresponding to the second branch of the trigeminal nerve. After treatment with 1200 mg carbamazepine daily, the attacks disappeared. Full remission was achieved, and carbamazepine therapy was continued. Pain attacks of a quite different character then appeared; their clinical picture corresponded to cluster headache. After treatment with cyproheptadine, the cluster headache attacks ceased, but 2 days later, before the discontinuation of the treatment, the attacks of trigeminal neuralgia reappeared. Treatment with carbamazepine was started again, and there was remission of the trigeminal neuralgia after several weeks.

Carbamazepine↗
PubMed1986

Epidermal growth factor in human cerebrospinal fluid: reduced levels in amyotrophic lateral sclerosis.

Epidermal growth factor (EGF), a mitogenic peptide, is widely distributed within the brain and endocrine cells of the gastro-intestinal tract. Using EGF radioreceptor assay, the EGF level was measured in lumbar cerebrospinal fluid from five patients with amyotrophic lateral sclerosis (ALS) and seven patients with intervertebral disc disease as a control group. The patients with ALS showed reduced EGF levels to 662.4 +/- 207 pg/ml as compared with controls 1013 +/- 182.8 pg/ml (P less than 0.02). These results indicate a possible EGF involvement in the pathogenesis of ALS.

Aged↗
PubMed1986

Reduced lumbar cerebrospinal fluid corticotropin releasing factor (CRF) levels in amyotrophic lateral sclerosis.

Corticotropin-releasing factor (CRF) is widely distributed within the brain and spinal cord and may have direct extrahypophysiotrophic effects, independent of its pituitary action. The CRF level was measured using, the RIA method in cerebrospinal fluid (CSF) from 5 patients with amyotrophic lateral sclerosis (ALS), and in CSF from 10 patients with discopathy, treated as a controlled group. The median values of CRF level in the patients with ALS was 27.5 pg/ml, and this value was significantly lower than in controls, 53.5 pg/ml (P less than 0.05). These results suggests that CRF may be related in the pathophysiology of ALS.

Aged↗
PubMed1985

Use of testosterone in the treatment of cluster headache.

The study was carried out on 15 men suffering from the episodic form (12 patients) and the chronic one (3 patients) of cluster headache. Before treatment the patients did not receive any drugs, and after determining the index of attacks the treatment was commenced. For 7-10 days patients were given testosteronum propionicum (25 mg) once a day intramuscularly, and then for the same period of time testosterone (10 mg). Before treatment the index of attacks was 3.66 (total number of attacks 308). In the 1st week of treatment the index decreased to 1.11 (total number of attacks 94) and to 0.16 in the 2nd week. In 3 patients with the chronic form of cluster headache testosterone was ineffective.

Adult↗