Search PubMed⌕ Search

Biomedical subjects

A Kint

Publications and source records attributed to A Kint.

At least 55 records · Page 3Linked to original sources
PubMed1982

Morphological changes in the proximal area of the rat's hair follicle during early catagen. An electron-microscopic study.

This electron-microscopic study of the catagen phase shows that the first alteration of regression of the follicle is localized in the papilla, where the cells withdraw their offshoots and break the contact with the basal lamina. Both at the level of the papilla and of the bulb structures appear that increase the cell cohesion. Under the influence of the outer root sheath an upward migration occurs. This is followed by plication and thickening of the basal lamina. The alterations in the connective tissue sheath occur in a further stage. The first signs of autolysis occur in the center of the epithelial column. At the end of the catagen stage macrophages take care of the clearing-up.

Animals↗
PubMed1982

Microenvironment of Woringer-Kolopp's disease.

A localized form of 'Pagetoid reticulosis' (Woringer-Kolopp's disease) is described morphologically. It can be shown that ultrastructurally the 'Pagetoid cells' are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans' cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans' cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp's disease seems to build up the specific microenvironment for lymphoid cell reaction.

Epidermis↗
PubMed1981

[Lyell's disease (author's transl)].

In Lyell's disease different clinical patterns can be observed: (a) an acute scarlatiniform erythema, on which more or less extended bullae rapidly appear; (b) a morbilliform erythema, with bullae; (c) the dermatosis can start under the features of an erythema exsudativum multiforme; (d) the eruption may begin as a psoriasis pustulosa. From an internal point of view, disturbances of the liquid balance and the blood electrolyte level may appear as a consequence of the important loss of water and serum. Toxic hepatitis, nephritis or myocarditis are possible complications. The origin of the disease is toxic or bacterial. This differentiation is important because the prognosis is much more favorable when the origin is bacterial than when the disease is due to medicines. A differential diagnosis between both etiologies may be achieved by histological examination: when the origin is a toxic one, we can find subepidermal blisters, while the blisters are located under the horny layer when the disease is of bacterial origin. The disease process is not clear in the toxic form. In cases induced by staphylococci, the epidermal lesions are caused by an epidermolytic toxin. The treatment will especially tend to restore the fluid and electrolyte balance; if there is a bacterial etiology, antibiotics will be necessary. Corticoids are to be avoided.

Adolescent↗
PubMed1980

[Herpes gestationis. A histological and electron microscopic study (author's transl)].

The histology and electron microscopy of two cases of herpes gestationis is described (HG). It appears that at the histological as well as at the ultrastructural level, the blister of HG results from degenerative changes in the basal cells and is initially located in the epidermis. It is associated with spongiosis. As a consequence of the disappearance of the basal cell layer, the blister is secondarily found between the malpighian layer and the subepidermal basement membrane. Immunologically, C3 could be found at that dermo-epidermal junction. Although the immunological findings can be similar to those of BP, it is believed that HG and BP must be considered as different entities, because of the very particular clinical features of HG and because the blister formation is different in both diseases.

Adult↗
PubMed1980

[Erythema elevatum diutinum].

This 73-year-old lady presented since four years a clinically typical erythema elevatum diutinum. The disease responded very favourably to a treatment with chloroquine, whereas no improvement was obtained with dapsone.

Aged↗
PubMed1979

[Juvenile melanoma; a clinical and histological study].

Investigations were carried out in 52 female and 18 male patients, aged between 2 and 49 years, with juvenile melanoma. The tumor occured as a solitary tumor in all cases except one. It was mainly localized on the head (54%), and the extremities, on the trunk in three cases only. In 35% the tumor could be diagnosed clinically. Light microscopy revealed in 37.1% spindle cells, in 17.1% epitheloid cells, and in 45.7% the juvenile melanoma was of the mixed type. A proliferation of the vascular endothelial cells (37.1%) as well as immature looking mast cells in the tumor region were prominent findings. A transepidermal elimination of tumor cell nests was noted in one case. The other results are in agreement with earlier descriptions of this tumor.

Adolescent↗
PubMed1978

Comparative electron microscopic study between Mendes da Costa's disease and recessive epidermolysis bullosa dystrophica.

An electron microscopic study of Mendes da Costa's disease (MCD) has been undertaken to determine whether this disease is a variant of epidermolysis bullosa dystrophica, or should be classified as a separate disease entity. It was shown that in MCD lacunae occur in the lower layers of the epidermis, in the presence of normal anchoring fibrils. In the recessive form of epidermolysis bullosa dystrophica (EBD), however, no lacunae were found in the epidermis, and anchoring fibrils were absent. These findings support the concept that MCD should not be considered as a special form of epidermolysis bullosa dystrophica.

Adolescent↗