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Biomedical subjects

A Kennedy

Publications and source records attributed to A Kennedy.

At least 235 records · Page 13Linked to original sources
PubMed1969

Pathology and survival in operable cases of giant-cell carcinoma of the lung.

Giant-cell carcinoma of the lung is usually rapidly fatal and nearly all of the published cases have been described on the basis of postmortem findings. The surgical specimens from three resected giant-cell carcinomas are described and the subsequent courses of the patients are summarized. A further nine surgically treated cases have been found in the literature. Giant-cell carcinoma of the lung is thought to be an anaplastic variant of adenocarcinoma and its aggressive behaviour is a reflection of its degree of anaplasia. Despite the aggressive behaviour of this type of cancer, patients may survive for many years if the tumour is resected.

Adult↗
PubMedDate not supplied

Limited abdominal MRI in the evaluation of acute right upper quadrant pain.

BACKGROUND: We investigated whether limited abdominal magnetic resonance imaging (MRI) is as effective as transabdominal ultrasound (US) in evaluating patients presenting with acute right upper quadrant pain. METHODS: Twenty-four patients underwent evaluation with a limited abdominal MRI using single-shot fast spin-echo sequences and a right upper quadrant US within 24 h. Two MRI and two US readers independently evaluated the images for gallstones, gallbladder wall thickness, pericholecystic fluid, acute cholecystitis, visualization of the common bile duct, and requests for further imaging. US and MRI findings were compared. Surgical pathology was the gold standard. RESULTS: MRI and US demonstrated no statistically significant difference in the diagnosis of gallbladder wall thickening, the presence of gallstones or pericholecystic fluid, or the diagnosis of acute cholecystitis (p > 0.05). The sensitivity of both for acute cholecystitis was 50%, with specificities of 89% and 86% for US and MRI, respectively. US readers more frequently requested additional tests and displayed more variability in whether they could adequately see the common bile duct. CONCLUSION: Limited MRI is equivalent to US in diagnosing gallstones, gallbladder wall thickening, pericholecystic fluid, and acute cholecystitis in patients presenting with symptoms of acute right upper quadrant pain. Especially in sonographically challenging patients, limited MRI may provide a faster, easier method of diagnosis.

Abdomen, Acute↗
PubMedDate not supplied

Fetal ultrasound.

Ultrasound provides an opportunity to visualize the fetus and to assess its response to the intrauterine environment. The topic of fetal ultrasound is broad, and whole textbooks have been devoted to areas such as the diagnosis of anomalies. In an effort to provide current practical information, I have focused on the most common clinical questions asked when pregnant women are referred for obstetric ultrasound. We review the diagnoses of oligohydramnios, polyhydramnios, intrauterine growth retardation (IUGR), macrosomia, multiple pregnancy, and common fetal anomalies. Noninvasive assessment of fetal well-being is addressed, along with the use of sonography to refine risk assessment in patients with abnormal antenatal screening tests.

Congenital Abnormalities↗
PubMedDate not supplied

Impairment of neocortical metabolism predicts progression in Alzheimer's disease.

Progression rates of Alzheimer's disease (AD) vary considerably, and they are particularly difficult to predict in patients with mild cognitive impairment. We performed a prospective multicenter cohort study in 186 patients with possible or probable AD, mostly with presenile onset. In a cross-sectional analysis at entry, impairment of glucose metabolism in temporoparietal or frontal association areas measured with positron emission tomography was significantly associated with dementia severity, clinical classification as possible versus probable AD, presence of multiple cognitive deficits and history of progression. A prospective longitudinal analysis showed a significant association between initial metabolic impairment and subsequent clinical deterioration. In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment. Copyrightz1999S.KargerAG, Basel

Aged↗